A biodynamical model of human T-cell development and pathology: design, testing and validation

  • Michael E. Brandt
  • Gerhard R. F. Krueger
  • Guanyu Wang
Part of the Cancer Growth and Progression book series (CAGP, volume 11)


We describe a coupled ordinary differential equation model of human T-cell proliferative disorders based upon documented changes in various pools such as the bone marrow, thymic compartments and peripheral blood. The conceptual design of the model is based upon previously collected experimental data, its testing and validation by comparing with normal human cell pool data at various ages as well as their changes in response to HTLV-1, HHV-6 and HIV-1 viral infections. These viruses were chosen because they all target the same CD4 lymphocyte, yet produce different response patterns such as hyperplasia, aplasia and neoplasia. They were also selected because respective cell pool data were available for comparison with detailed human studies. The ultimate task of this modeling effort is to simulate the development of T-cell lymphomas and other immunoproliferative or aproliferative (i.e. aplastic) abnormalities reported in the literature.


Immune system T-lymphocytes Proliferative diseases Biocomputational modeling 


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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Michael E. Brandt
    • 1
    • 2
  • Gerhard R. F. Krueger
    • 1
  • Guanyu Wang
    • 1
  1. 1.University of Texas-Houston Health Science Center – Medical SchoolUSA
  2. 2.School of Health Information SciencesUSA

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