Original minimally invasive surgical procedure for three-vascular occlusion (3-VO) model of Alzheimer’s vascular dementia (AD) in aged rats was developed. The main pathological changes observed following 50-min brain ischemia were characterized by decreased parameters of oxidative phosphorylation in brain and heart mitochondria. Four weeks supplementation of liposoluble CoQ10 after cerebral ischemia/reperfusion (I/R) injury, regenerated AD brain and myocardium mitochondrial oxidative phosphorylation function. These results indicate, that CoQ10 supplementation may stimulate regeneration of the damaged brain and heart mitochondria in patients with Alzheimer’s disease.
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Gvozdjáková, A., Horecký, J., Vančová, O., Kucharská, J., Bauerová, K., Poništ, S. (2008). Coenzyme Q10 Supplementation in Experimental Medicine. In: Gvozdjáková, A. (eds) Mitochondrial Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6714-3_18
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