Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?

  • Markus Wyss
  • Olivier Braissant
  • Ivo Pischel
  • Gajja S. Salomons
  • Andreas Schulze
  • Sylvia Stockler
  • Theo Wallimann
Part of the Subcellular Biochemistry book series (SCBI, volume 46)


Many links are reported or suspected between the functioning of creatine, phosphocreatine, the creatine kinase isoenzymes or the creatine biosynthesis enzymes on one hand, and health or disease on the other hand. The aim of the present book was to outline our current understanding on many of these links. In this chapter, we summarize the main messages and conclusions presented in this book. In addition, we refer to a number of recent publications that highlight the pleiotropy in physiological functions of creatine and creatine kinase, and which suggest that numerous discoveries on new functions of this system are still ahead of us. Finally, we present our views on the most promising future avenues of research to deepen our knowledge on creatine and creatine kinase. In particular, we elaborate on how state-of-the-art high-throughput analytical (“omics”) technologies and systems biology approaches may be used successfully to unravel the complex network of interdependent physiological functions related to creatine and creatine kinase


Creatine Kinase Creatine Kinase Activity Creatine Supplementation Creatine Monohydrate Superior Olivary Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2007

Authors and Affiliations

  • Markus Wyss
    • 1
  • Olivier Braissant
    • 2
  • Ivo Pischel
    • 3
  • Gajja S. Salomons
    • 4
  • Andreas Schulze
    • 5
  • Sylvia Stockler
    • 6
  • Theo Wallimann
    • 7
  1. 1.DSM Nutritional Products Ltd., Biotechnology R&DCH-4002 BaselSwitzerland
  2. 2.Clinical Chemistry LaboratoryCentre Hospitalier Universitaire Vaudois and University of LausanneCH-1011 LausanneSwitzerland
  3. 3.Finzelberg GmbH & Co. KGKoblenzer Straße 48-56Germany
  4. 4.Department of Clinical Chemistry, Metabolic UnitVU University Medical CenterDe Boelelaan 1117The Netherlands
  5. 5.Department of Paediatrics Division of Clinical and Metabolic Genetics and Research Institute, The Hospital for Sick ChildrenUniversity of Toronto555 University AvenueCanada
  6. 6.Department of Pediatrics, Division of Biochemical Diseases, British Columbia Children’s HospitalUniversity of British ColumbiaVancouverCanada
  7. 7.Institute of Cell Biology, ETH ZurichHönggerberg HPM-D24.1, Schafmattstrasse 1Switzerland

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