In vitro models to analyse fungal infection

  • Susanne Gola
  • David M. Arana
  • Rebeca Alonso-Monge
  • Elvira Román
  • Jesús Pla

According to the molecular Koch’s postulates (Falkow, 1988), putative virulence traits can be identified in a pathogen because deletion of the gene encoding a virulence factor in an otherwise wild-type strain generates a mutant with reduced pathogenicity in a certain model of experimental infection.

This chapter reviews the main in vitro models for epithelial, endothelial, and immune system cells. It outlines the available techniques to characterize and to quantify host cell-pathogen interactions following a structure as preset by the pathogenic course itself. Examples on how the in vitro methodology has contributed to clarify the effective molecular mechanism in the single steps are included for the different fungal pathogens.

Keywords

Permeability Surfactant Chromium Sarcoma Methionine 

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Copyright information

© Springer 2007

Authors and Affiliations

  • Susanne Gola
    • 1
  • David M. Arana
    • 1
  • Rebeca Alonso-Monge
    • 1
  • Elvira Román
    • 1
  • Jesús Pla
    • 1
  1. 1.Departamento de Microbiología II, Facultad de FarmaciaUniversidad Complutense de MadridSpain

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