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Bone Homeostasis: An Emerging Role for the Renin-Angiotensin System

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Frontiers in Research of the Renin-Angiotensin System on Human Disease

Part of the book series: Proteases in Biology and Disease ((PBAD,volume 7))

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References

  • Alwan, S., Polifka, J.E., and Friedman, J.M., 2005, Angiotensin II receptor antagonist treatment during pregnancy. Birth Defects Res A Clin Mol Teratol. 73: 123–30.

    Article  PubMed  CAS  Google Scholar 

  • Blair, J.M., Zhou, H., Seibel, M.J., and Dunstan, C.R., 2006, Mechanisms of Disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nat Clin Pract Oncol. 3:41–49.

    Article  PubMed  CAS  Google Scholar 

  • Broulik, P.D., Tesar, V., Zima, T., and Jirsa, M., 2001, Impact of antihypertensive therapy on the skeleton: effects of enalapril and AT1 receptor antagonist losartan in female rats. Physiol Res. 50: 353–358.

    PubMed  CAS  Google Scholar 

  • Brown, R.E., 2000, Angiotensin-converting enzyme, transforming growth factor β1, and interleukin 11 in the osteolytic lesions of Langerhans cell Histiocytosis. Arch Pathol Lab Med. 124: 1287–1290.

    PubMed  CAS  Google Scholar 

  • Bowler, W.B., Gallagher, J.A., and Bilbe, G., 1998. G-protein coupled receptors in bone. Front Biosci. 1: 769–80.

    Google Scholar 

  • Bouscarel, B., Wilson, P.B., Blackmore, P.F., Lynch, C.J., and Exton, J.H., 1988, Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes. J Biol Chem 263: 14920–149204.

    PubMed  CAS  Google Scholar 

  • Bucay, S., Sarosi, J., Dunstan, CR., Morony, S., Tarpley, J., 1998, Osteoprotegerin-deficient mice develop early-onset osteoporosis and arterial calcification. Gene Dev 12: 1260–1268.

    PubMed  CAS  Google Scholar 

  • Buttar, H.S., 1997, An overview of the influence of ACE inhibitors on fetal-placental circulation and perinatal development. Molec Cell Biochem. 176: 61–71.

    Article  PubMed  CAS  Google Scholar 

  • Cappuccio, F.P., Meilahn, E., Zmuda, J.M., Cauley, J.A., and the Study of Osteoporotic Fractures Research Group, 1999, High blood pressure and bone mineral loss in elderly white women: A prospective study. Lancet. 354: 971–975.

    Article  PubMed  CAS  Google Scholar 

  • Chai, S.Y., Fernando, R., Peck, G., Ye, S.Y., Mendelsohn, F.A., Jenkins, T.A., and Albiston, A.L., 2004, The angiotensin IV/AT4 receptor. Cell Mol Life Sci. 61: 2728–2737.

    Article  PubMed  CAS  Google Scholar 

  • De Gasparo, M., Catt, K.J., Inagami, T., Wright, J.W., and Unger, T.H., 2000, The angiotensin II receptors. Pharmacol Rev. 52: 415–472.

    PubMed  Google Scholar 

  • De Leeuw, P.W., 2006, The use of angiotensin converting enzyme (ACE) inhibitors during pregnancy clearly increases the risk of congenital malformations. Ned Tijdschr Geneeskd. 150: 1605–1607.

    PubMed  Google Scholar 

  • Dendorfer, A., Dominiak, P., and Schunkert, H., 2005, ACE inhibitors and angiotensin II receptor antagonists. Handb Exp Pharmacol. 170: 407–42.

    Article  PubMed  CAS  Google Scholar 

  • Dossing, D.A., and Stern, P.H., 2005, Receptor activator of NF-kappa B ligand protein expression in UMR-106 cells is differentially regulated by parathyroid hormone and calcitriol. J Cell Biochem. 95: 1029–1041.

    Article  PubMed  CAS  Google Scholar 

  • Engeli, S., Schling, P., Gorzelniak, K., Boschmann, M., Janke, J., Ailhaud, G., Teboul, M., Massiéra, F., and Sharma, A.M., 2003, The adipose-tissue renin–angiotensin–aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol. 35: 807–825.

    Article  PubMed  CAS  Google Scholar 

  • Fishel, R.S., Eisenberg, S., Shai, S.Y., Redden, R.A., Bernstein, K.E., and Berk, B.C., 1995, Glucocorticoids induce angiotensin-converting enzyme expression in vascular smooth muscle. Hypertension. 25: 343–349.

    PubMed  CAS  Google Scholar 

  • Fox, W.F., and Lovibond, A.C., 2005, Current insights into the role of transforming growth factor-β in bone resorption. Molec Cell Endocrinol. 243:19–26.

    Article  PubMed  CAS  Google Scholar 

  • Gard, P., 2002, The role of angiotensin II in cognition and behaviour. Eur J Pharmacol. 438: 1–14.

    Article  PubMed  CAS  Google Scholar 

  • Guy, J.L., Lamber, D.J., Warner, F.J., Hooper, N.M., and Turner, A.J., 2005, Membrane-associated zinc peptidase families: comparing ACE and ACE2. Biochim Biophys Acta. 1751: 2–8.

    PubMed  CAS  Google Scholar 

  • Hagiwara, H., Hiruma, Y., Inoue, A., Yamaguchi, A., and Hirose, S., 1998, Deceleration by angiotensin II of the differentiation and bone formation of rat calvarial osteoblastic cells. Endocrinol. 156: 543–50.

    Article  CAS  Google Scholar 

  • Hatton, R.M., Stimpel, and Chambers T.J., 1997, Angiotensin II is generated from angiotensin I by bone cells and stimulates osteoclastic bone resorption in vitro. J Endocrinol. 152: 5–10.

    Article  PubMed  CAS  Google Scholar 

  • Hiruma, Y., Inoue, A., Hirose, S., and Hagiwara, H., 1997, Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat calvariae. Biochem Biophys Res Commun. 230: 176–8.

    Article  PubMed  CAS  Google Scholar 

  • Imanishi, T., Hano, T., and Nishio, I., 2004, Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens. 23: 97–104.

    Article  Google Scholar 

  • Jimi, E., Nakamura, I., Amano, H., Taguchi, Y., Tsurukai, T., Tamura, M., Nakahashi, N., and Suda, T., 1996, Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology. 137: 2187–90.

    CAS  Google Scholar 

  • Kanaan, R.A., and Kanaan, L.A., 2006, Transforming growth factor β1, bone connection. Med Sci Monit. 12: 164–169.

    Google Scholar 

  • Kershaw, E.E., and Flier, J., 2004, Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 2548–2556.

    Google Scholar 

  • Lacey, D.L., Timms, E., Tan, H.-L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.-X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., and Boyle, W. J., 1998, Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93: 165–176.

    Article  PubMed  CAS  Google Scholar 

  • Lamparter, S., Kling, L., Schrader, M., Ziegler, R., and Pfeilschifter, J., 1998, Effects of angiotensin II on bone cells in vitro. J Cell Physiol. 175: 89–98.

    Article  PubMed  CAS  Google Scholar 

  • Lavoie, J.L., and Sigmund, C.D., 2003, Minireview: Overview of the renin-angiotensin system—an endocrine and paracrine system. Endocrinology 144: 2179–2183.

    Article  PubMed  CAS  Google Scholar 

  • Lee, S-K., and Lorenzo, J., 2006, Cyrokine regulating osteoclast formation and function. Curr Opin Rheumatol. 411–418.

    Google Scholar 

  • Leung, P.S., 2004, The peptide hormone angiotensin II: its new functions in tissues and organs. Curr Protein Pept Sci. 5: 267–273.

    Article  PubMed  CAS  Google Scholar 

  • Leung, P.S., Sernia, C., 2003, The renin-angiotensin system and male reproduction: new functions for old hormones. Molec Cell Endocrin. 30: 263–70.

    Article  CAS  Google Scholar 

  • Levy, B.I., 2005, How to explain the differences between renin angiotensin system modulators. Am J Hypertens. 134S–141S.

    Google Scholar 

  • Lynn, H., Kwok, T., Wong, S., Woo, J., and Leung, P.C., 2006, Angiotensin Converting enzyme use is associated with higher bone mineral density in elderly chinese. Bone. 38: 584–588.

    Article  PubMed  CAS  Google Scholar 

  • Massiera, F., Seydoux, J., Geloen, A., Quignard-Boulange, A., Turban, S., Saint-Marc, P., Fukamizu, A., Negrel, R., Ailhaud, G., and Teboul, M., 2001, Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinol. 142: 5220–5225.

    Article  CAS  Google Scholar 

  • Mastrobattista, J.M., 1997, Angiotensin converting enzyme inhibitors in pregnancy. Semin Perinatol. 21: 124–134.

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki, M., and Takai, S., 2006, Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase. J Pharmacol Sci. 100: 391–7.

    Article  PubMed  CAS  Google Scholar 

  • Mosmann, T., 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 16: 55–63.

    Article  Google Scholar 

  • Mundy, G.R., and Elefteriou, F., 2006, Boning up on ephrin signaling. Cell. 126: 441–443.

    Article  PubMed  CAS  Google Scholar 

  • Nishiya, Y., and Sugimoto, S., 2001, Effects of various antihypertensive drugs on the function of osteoblast. Biol Pharm Bull. 24:628–33

    Article  PubMed  CAS  Google Scholar 

  • Paul, M., Poyan Mehr, A., and Kreuz, R., 2006, Physiology of local renin-angiotensin systems. Physiol Rev. 86: 747–803.

    Article  PubMed  CAS  Google Scholar 

  • Perez-Castrillon, J.L., Justo, I., Silva, J., Sanz, A., Escudero, J.C.M., Igea, R., Escudero, P., Pueyo, C., Diaz, C., Hernandez, G., and Duenas, A., 2003, Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women. Am. J. Hypertens. 233–235.

    Google Scholar 

  • Perez-Castrillon, J.L., Silva, J., Justo, I., Sanz, A., Martin-Luquero, M., Igea, R., Escudero, P., Pueyo, C., Diaz, C., Hernandez, G., and Duenas, A., 2003, Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: Relationship with angiotensin converting enzyme polymorphisms. Am J Hypertens. 16:453–459.

    Article  PubMed  CAS  Google Scholar 

  • Quan, A., 2006, Fetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonists. Early Hum Dev. 82: 23–28.

    Article  PubMed  CAS  Google Scholar 

  • Quarles, LD., Yohay DA, Lever LW., Caton, R., Wenstrup RJ, 1992, Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J Bone Miner Res. 7: 683–92.

    Article  PubMed  CAS  Google Scholar 

  • Reaux-Le Goazigo, A., Iturrioz, X., Fassot, C., Claperon, C., Roques, B.P., and Llorens-Cortes, C., 2005, Role of angiotensin III in hypertension. Curr Hypertens Rep. 7: 128–134.

    Article  PubMed  CAS  Google Scholar 

  • Rejmark, L., Vestergaard , P., and Mosekilde, L., 2006. Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: a nationwide case-control study. J Hypertens. 24: : 581–9.

    Article  CAS  Google Scholar 

  • Robling, A., Castillo, A.B., and Turner, C.H., 2006, Biomechanical and molecular regulation of bone remodeling. Ann RevBiomed Eng. 8: 455–498.

    Article  CAS  Google Scholar 

  • Sanada, M., Taguchi, A., Higashi, Y., Tsuda, M., Kodama, I., Yoshizumi, M., and Ohama, K., 2004, Forearm endothelial function and bone mineral loss in postmenopausal women. Atherosclerosis. 176: 387–392.

    Article  PubMed  CAS  Google Scholar 

  • Sanchez, C.P., He, Y.-Z., Leiferman, E., and Wilsman, N., 2004, Bone elongation in rats with renal failure and mild or advanced secondary hyperparathyroidism. Kidn Inter. 65: 1740–1748.

    Article  CAS  Google Scholar 

  • Schurman, S.J., Bergstrom, W.H., Shoemaker, L.R., and Welch, T.R., 2004, Angiotensin II reduced calcium uptake into bone. Pediatr Nephrol. 19: 33–35.

    Article  PubMed  Google Scholar 

  • Sernia, C., Li, L., and Huang, H., 2005, Localization of angiotensin receptors and angiotensinogen in the epiphyseal plate of rat tibia. ANZBMS proceedings P97.

    Google Scholar 

  • Siejka, A., Melen-Mucha, G., Mucha, S.A., and Pawlikowski, M., 2006, Angiotensins II and IV modulate adrenocortical cell proliferation in ovariectomized rats. J Physiol Pharmacol. 57: 451–456.

    PubMed  CAS  Google Scholar 

  • Simonet, WS., Lacey, DL., Dunstan, CR., Kelley M. et al. 1997. Osteoprotogerin: A novel secreted protein involved in the regulation of bone density. Cell 89: 309–319.

    Article  PubMed  CAS  Google Scholar 

  • Stimpel, M., Jee, W.S., Ma, Y., Yamamoto, N., and Chen, Y., 1995, Impact of antihypertensive therapy on postmenopausal osteoporosis: Effects of the angiotensin converting enzyme inhibitor moexipril, 17 beta-estradiol and their combination on the ovariectomy-induced cancellous bone loss in young rats. Journal of Hypertension. 13: 1852–1856.

    Article  PubMed  CAS  Google Scholar 

  • Tabacova, S., 2005, Mode of action: angiotensin-converting enzyme inhibition–developmental effects associated with exposure to ACE inhibitors. Crit Rev Toxicol. 35: 747–55.

    Article  PubMed  CAS  Google Scholar 

  • Tabacova, S., Little, R., Tsong, Y., Vega, A., and Kimmel, C.A., 2003, Adverse pregnancy outcomes associated with maternal enalapril antihypertensive treatment. Pharmacoepidemiol and Drug Safety. 12:633–646.

    Article  CAS  Google Scholar 

  • Theoleyre, S., Wittrant, Y., Kwan Tat, S., Fortun, Y., Redini, F., and Heymann, D., 2004. The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Cytokine Growth Factor Rev. 15,457–75.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, W.G., and Mendelsohn, F.A.O., 2003, Angiotensin receptors: form and function and distribution. Int J Biochem Cell Biol. 35: 774–779.

    Article  PubMed  CAS  Google Scholar 

  • Tsuda, K., Nishio, I., and Masuyama, Y., 2001, Bone Mineral Density in Women With Essential Hypertension. Am. J. Hypertens. 14: 704–707.

    Article  PubMed  CAS  Google Scholar 

  • Uchimura, E., Machida, H., Kotobuki, N., Kihara, T., Kitamura, S., Ikeuchi, M., Hirose, M., Miyake, J., and Ohgushi, H., 2003, In-situ visualization and quantification of mineralization of cultured osteogenetic cells. Calcif Tiss Int. 73: 575–583.

    Article  CAS  Google Scholar 

  • Wada, T., Nakashima, T., Hiroshi, N., and Penninger, J.M., 2006, RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Molec Med. 12: 17–25.

    Article  CAS  Google Scholar 

  • Wilms, H., Rosenstiel, P., Unger, T., Deuschl, G., and Lucius, R., 2005, Neuroprotection with angiotensin receptor antagonists: a review of the evidence and potential mechanisms. Am J Cardiovasc Drugs. 5: 245–53.

    Article  PubMed  CAS  Google Scholar 

  • Wittrant, Y., Theoleyre, S., Chipoy, C., Padrines, M., Blanchard, M., Heymann, D., and Redini, F., 2004, RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. Biochim Biophys Acta. 704: 49–57.

    Google Scholar 

  • Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., Tsuda, E., Morinaga, T., Higashio, K., Udagawa, N., Takahashi, N., and Suda, T., 1998, Osteoclast differentiation factor is a ligand for osteoprotegerin osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA. 3597–3602.

    Google Scholar 

  • Zhang, J., Fu, M., Myles, D., Zhu, X., Du, J., Cao, X., and Chen, Y.E., 2002, PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways. FEBS Lett. 521: 180–184.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, H., Sun, G.-Y., 2006, Expression and Regulation of AT1 Receptor in Rat Lung Microvascular Endothelial Cell. J Surg Res. 134: 190–197.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology & Pharmacology, School of Biomedical Science, University of Queensland, Brisbane, Australia

    C. Sernia, H. Huang, K. Nguyuen, Y-H. Li, S. Hsu, M. Chen, N. Yu & M. Forwood

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  1. C. Sernia
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  2. H. Huang
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  1. Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Po Sing Leung PhD

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Sernia, C. et al. (2007). Bone Homeostasis: An Emerging Role for the Renin-Angiotensin System. In: Leung, P.S. (eds) Frontiers in Research of the Renin-Angiotensin System on Human Disease. Proteases in Biology and Disease, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6372-5_9

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