Skip to main content
SpringerLink
Log in

The Renin-Angiotensin System in Pancreatic Stellate Cells: Implications in the Development and Progression of Type 2 Diabetes Mellitus

  • Chapter
Frontiers in Research of the Renin-Angiotensin System on Human Disease

Part of the book series: Proteases in Biology and Disease ((PBAD,volume 7))

  • 365 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS, 1998, Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 43: 128–133.

    Article  PubMed  CAS  Google Scholar 

  • Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS, 1999, Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 44: 534–541.

    Article  PubMed  CAS  Google Scholar 

  • Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G, 1998, Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 115: 421–432.

    Article  PubMed  CAS  Google Scholar 

  • Bataller R, Sancho-Bru P, Gines P, Lora JM, Al-Garawi A, Sole M, Colmenero J, Nicolas JM, Jimenez W, Weich N, Gutierrez-Ramos JC, Arroyo V, Rodes J. 2003. Activated human hepatic stellate cells express the renin-angiotensin system andsynthesize angiotensin II. Gastroenterology 125: 117–125.

    Article  PubMed  CAS  Google Scholar 

  • Campbell SE, Katwa LC, 1997, Angiotensin II stimulated expression of transforming growth factor-b1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol. 29: 1947–1958.

    Article  PubMed  CAS  Google Scholar 

  • Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJ, Holman RR, Turner RC, 1988, Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis:quantitative changes in the pancreas in type 2 diabetes. Diabetes Res Clin Prac. 4: 151–159.

    Google Scholar 

  • Cooper ME, Tikellis C, Thomas MC, 2006, Preventing diabetes in patients with hypertension: one more reason to block the renin-angiotensin system. Journal of Hypertension. 24(1):S57–S63.

    Article  PubMed  CAS  Google Scholar 

  • Crandall DL, Herzlinger HE, Saunders BD, Armellino DC, Kral JG, 1994, Distribution of angiotensin II receptors in rat and human adipocytes. J Lipid Res. 35: 1378–1385.

    PubMed  CAS  Google Scholar 

  • Fukushima M, Suzuki H, Seino Y, 2004, Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes. Diabetes Research and Clinical Practice 66(Suppl1):S37–S43.

    Article  PubMed  CAS  Google Scholar 

  • Gepts W, Lecompte PM, 1981, The pancreatic islets in diabetes. Am J Med. 70:105–115.

    Article  PubMed  CAS  Google Scholar 

  • Giacchetti G, Sechi LA, Rilli S, Carey RM, 2005, The renin-angiotensin-aldosterone system, glucose metabolism and diabetes. Trends Endocrinol Metab. 16: 120–126.

    Article  PubMed  CAS  Google Scholar 

  • Haber PS, Keogh GW, Apte MV, Moran CS, Stewart NL, Crawford DH, Pirola RC, McCaughan GW, Ramm GA, Wilson JS, 1999, Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol. 155: 1087–1095.

    PubMed  CAS  Google Scholar 

  • Hama K, Ohnishi H, Yasuda H, Ueda N, Mashima H, Satoh Y, Hanatsuka K, Kita H, Ohashi A, Tamada K, Sugano K, 2004, Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation. Biochem Biophys Res Commun. 19;315(4): 905–911.

    Article  CAS  Google Scholar 

  • Hansson L, Lindholm DH, Niskanen L, Lanke J, Hedner T, Niklason A, 1999, Effects of angiotensin-converting enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPP) randomized trial. Lancet. 353: 611–616

    Article  PubMed  CAS  Google Scholar 

  • Hsieh TJ, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Chan JS, 2002, High glucose stimulates angiotensinogen gene expression via reactive oxygenspecies generation in rat kidney proximal tubular cells. Endocrinology. 143: 2975–2985.

    Article  PubMed  CAS  Google Scholar 

  • Jaster R, 2004, Molecular regulation of pancreatic stellate cell function. Mol Cancer. 6: 1–8.

    Google Scholar 

  • Jaster R, Sparmann G, Emmrich J, Liebe S, 2002, Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut. 51: 579–584.

    Article  PubMed  CAS  Google Scholar 

  • Ken S, Nobuhisa Y, Tohru T, 1979, Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects. Tohoku J Exp Med. 129:273–283.

    Google Scholar 

  • Kjeldsen SE, Julius S, Mancia G, McInnes GT, Hua T, Weber MA, Coca A, Ekman S, Girerd X, Jamerson K, Larochelle P, MacDonald TM, Schmieder RE, Schork MA, Stolt P, Viskoper R, Widimsky J, Zanchetti A; VALUE Trial Investigators, 2006, Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial. J Hypertens. 24: 1405–1412.

    Article  PubMed  CAS  Google Scholar 

  • Kloppel G, Lohr M, Habich K, Oberholzer M, Heitz P, 1985, Islet pathology and pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Path Res. 4:110–125.

    CAS  Google Scholar 

  • Ko SH, Kwon HS, Kim SR, Moon SD, Ahn YB, Song KH, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Park CG, Lee IK, Yoon KH, 2004, Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochem Biophys Res Commun. 26: 114–122.

    Article  CAS  Google Scholar 

  • Ko SH, Hong OK, Kim JW, Ahn YB, Song KH, Cha BY, Son HY, Kim MJ, Jeong IK, Yoon KH, 2006, High glucose increases extracellular matrix production in pancreatic stellate cells by activating the renin-angiotensin system. J Cell Biochem. 15:343–355.

    Article  CAS  Google Scholar 

  • Kruse ML, Hildebrand PB, Timke C, Folsch UR, Schmidt WE, 2000, TGF beta1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul Pept. 90(1-3): 47–52.

    Article  PubMed  CAS  Google Scholar 

  • Kuno A, Yamada T, Masuda K, Ogawa K, Sogawa M, Nakamura S, Nakazawa T, Ohara H, Nomura T, Joh T, Shirai T, Itoh M, 2003, Angiotensin-converting enzyme inhibitor attenuates pancreas inflammation and fibrosis in male wistar Bonn/Kobori rats. Gastroenterology. 124: 1010–1019.

    Article  PubMed  CAS  Google Scholar 

  • Leehey DJ, Singh AK, Alavi N, Singh R, 2000, Role of angiotensin II in diabetic nephropathy. Kidney Int Suppl. 77: S93–98.

    Article  PubMed  CAS  Google Scholar 

  • Leung PS, Chan WP, Wong TP, Sernia C, 1999, Expression and localization of the renin-angiotensin system in the rat pancreas. J Endocrinol. 160: 13–19.

    Article  PubMed  CAS  Google Scholar 

  • Leung PS, Carlsson PO, 2001, Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas. J Mol Endocrinol. 26: 155–164.

    Article  PubMed  CAS  Google Scholar 

  • Leung PS, Chappell MC, 2003, A local pancreatic renin-angiotensin system: endocrine and exocrine roles. Int J Biochem Cell Biol. 35: 838–846.

    Article  PubMed  CAS  Google Scholar 

  • Leung PS, Carlsson PO, 2005, Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus. Pancreas. 30: 293–298.

    Article  PubMed  CAS  Google Scholar 

  • Liberopoulos EN, Tsouli S, Mikhailidis DP, Elisaf MS, 2006, Preventing type 2 diabetes in high risk patients: an overview of lifestyle and pharmacological measures. Curr Drug Targets. 7(2):211–228.

    Article  PubMed  CAS  Google Scholar 

  • Lindholm LH, Ibsen H, Dahlof B, Devereux RB, Beevers G, de Faire U, Fyhrquist F, Julius S, Kjeldsen SE, Kristiansson K, Lederballe-Pedersen O, Nieminen MS, Omvik P, Oparil S, Wedel H, Aurup P, Edelman J, Snapinn S; LIFE Study Group, 2002, Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet. 23: 1004–1010.

    Article  Google Scholar 

  • Lindstrom J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemio K, Hamalainen H, Harkonen P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Paturi M, Sundvall J, Valle TT, Uusitupa M, Tuomilehto J; Finnish Diabetes Prevention Study Groupm 2006, Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet. 368(9548):1673–1679.

    Article  PubMed  Google Scholar 

  • Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, McAnulty RJ, Laurent GJ, 2004, Angiotensin II and the fibroproliferative response to acute lung injury. Am J Physiol Lung Cell Mol Physiol. 286:L156-L164.

    Article  PubMed  CAS  Google Scholar 

  • Masamune A, Satoh M, Kikuta K, Sakai Y, Satoh A, Shimosegawa T, 2003, Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells. J Pharmacol Exp Ther. 304(1):8–14.

    Article  PubMed  CAS  Google Scholar 

  • McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, Oldfield BJ, Mendelsohn FA, Chai SYI, 2003, The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol. 35: 901–918.

    Article  PubMed  CAS  Google Scholar 

  • Nagashio Y, Asaumi H, Watanabe S, Nomiyama Y, Taguchi M, Tashiro M, Sugaya T, Otsuki M, 2004, Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 287: G170-G177.

    Article  PubMed  CAS  Google Scholar 

  • Paradis V, Perlemuter G, Bonvoust F, Dargere D, Parfait B, Vidaud M, Conti M, Huet S, Ba N, Buffet C, Bedossa P, 2001, High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology. 34(4 Pt 1):738–744.

    Article  PubMed  CAS  Google Scholar 

  • Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB, 1999, Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol. 277(1 Pt 1): C1-C9.

    PubMed  CAS  Google Scholar 

  • Reinehr R, Zoller S, Klonowski-Stumpe H, Kordes C, Haussinger D, 2004, Effects of angiotensin II on rat pancreatic stellate cells. Pancreas. 28: 129–137.

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Ortega M, Egido J, 1997, Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int. 52: 1497–1510.

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Ortega M, Lorenzo O, Ruperez M, Egido J, 2000, ACE inhibitors and AT(1) receptor antagonists-beyond the haemodynamic effect. Nephrol Dial Transplant. 15: 561–565.

    Article  PubMed  CAS  Google Scholar 

  • Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S, 2002, Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islets of Japanese type II diabetic patients. Diabetologia. 45:85–96.

    Article  PubMed  CAS  Google Scholar 

  • Singh M, Sinsek H, 1990, Ethanol and the pancreas: current status. Gastroenterology. 98: 1051–1062.

    PubMed  CAS  Google Scholar 

  • Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH, 1982, Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes. 31:694–700.

    Article  PubMed  CAS  Google Scholar 

  • Suda K, Miyano T, 1985, Bile pancreatitis. Arch Pathol Lab Med. 109: 433–436.

    PubMed  CAS  Google Scholar 

  • Suda K, Mogaki M, Oyama T, Matsumoto Y, 1990, Histopathologic and immunohistochemical studies on alcoholic pancreatitis and chronic obstructive pancreatitis: special emphasis on ductal obstruction and genesis of pancreatitis. Am J Gastroenterol. 85: 271–276.

    PubMed  CAS  Google Scholar 

  • Suda K, Tsukahara M, 1992, Histopathological and immunohistochemical studies on apparently uninvolved areas of pancreas in patients with acute pancreatitis. Arch Pathol Lab Med. 116: 934–937.

    PubMed  CAS  Google Scholar 

  • Suda K, SHiotsu H, Nakamura T, Akai J, Nakamura T, 1994, Pancreatic fibrosis in patients with chronic alcohol abuse: Correlation with alcoholic pancreatitis. Am J Gastroenterol. 89: 2060–2062.

    PubMed  CAS  Google Scholar 

  • Suda K, 2000, Pathogenesis and progression of human pancreatic fibrosis. Med Electron Microsc. 33: 200–206.

    Article  PubMed  CAS  Google Scholar 

  • Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Egido J, 2003, Inflammation and angiotensin II. Int J Biochem Cell Biol. 35: 881–900.

    Article  PubMed  CAS  Google Scholar 

  • Vidotti DB, Casarini DE, Cristovam PC, Leite CA, Schor N, Boim MA, 2004, High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol. 286: F1039–1045.

    Article  PubMed  CAS  Google Scholar 

  • Vinson GP, Teja R, Ho MM, Hinson JP, Puddefoot JR, 1998, The role of the tissue renin-angiotensin system in the response of the rat adrenal to exogenous angiotensin II. J Endocrinol. 158: 153–159.

    Article  PubMed  CAS  Google Scholar 

  • Watari N, Hotta Y, Mabuchi Y, 1982, Morphological studies on a vitamin A-storing cell and its complex with macrophage observed in mouse pancreatic tissues following excess vitamin A administration. Okajimas Folia Anat Jpn. 58: 837–858.

    PubMed  CAS  Google Scholar 

  • World Health Organization (http://www.who.int/mediacentre/factsheets. Last access 15 Dec 2006)

    Google Scholar 

  • Wolf G, Neilson EG, 1990, Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells. Am J Physiol. 259(5 Pt 2): F768–777.

    PubMed  CAS  Google Scholar 

  • Wolf G, Neilson EG, 1993, Angiotensin II as a renal growth factor. J Am Soc Nephrol. 3: 1531–1540.

    PubMed  CAS  Google Scholar 

  • Wolf G, Mueller E, Stahl RA, Ziyadeh FN, 1993, Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. J Clin Invest. 92: 1366–1372.

    Article  PubMed  CAS  Google Scholar 

  • Yokota T, Denham W, Murayama K, Pelham C, Joehl R, Bell RH Jr, 2002, Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis. J Surg Res. 104: 106–111.

    Article  PubMed  CAS  Google Scholar 

  • Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S, 2003, Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab. 88:2300–2308.

    Article  PubMed  CAS  Google Scholar 

  • Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, Zimmet P, Son HY, 2006, Epidemic obesity and type 2 diabetes in Asia. Lancet. 11:1681–1688.

    Article  Google Scholar 

  • Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Nakatani T, Tsujinoue H, Fukui H, 2001, Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats. Hepatology. 34(4 Pt 1): 745–750.

    PubMed  CAS  Google Scholar 

  • Yoshikawa H, Kihara Y, Taguchi M, Yamaguchi T, Nakamura H, Otsuki M, 2002, Role of TGF-beta1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol. 282: G549–558.

    PubMed  CAS  Google Scholar 

  • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G, 2000, Effects of an angiotensin-converting enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Eng J Med. 342:145–153

    Article  CAS  Google Scholar 

  • Yusuf S, Gerstein H, Hoogwerf B, Pogue J, Bosch J, Wolffenbuttel BHR, Zinman B, 2001, Ramipril and the development of diabetes. JAMA. 286:1882–1885

    Article  PubMed  CAS  Google Scholar 

  • Yusuf S, Ostergren JB, Gerstein HC, Pfeffer MA, Swedberg K, Granger CB, Olofsson B, Probstfield J, McMurray JV, 2005, Candesartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity Program Investigators, Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure. Circulation. 5: 48–53.

    Article  CAS  Google Scholar 

  • Zhang SL, Filep JG, Hohman TC, Tang SS, Ingelfinger JR, Chan JS, 1999, Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. Kidney Int. 55: 454–464.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Endocrinology & Metabolism, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea

    Seung-Hyun Ko, Yu-Bai Ahn, Ki-Ho Song & Kun-Ho Yoon

Authors
  1. Seung-Hyun Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu-Bai Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ki-Ho Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kun-Ho Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Po Sing Leung PhD

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Ko, SH., Ahn, YB., Song, KH., Yoon, KH. (2007). The Renin-Angiotensin System in Pancreatic Stellate Cells: Implications in the Development and Progression of Type 2 Diabetes Mellitus. In: Leung, P.S. (eds) Frontiers in Research of the Renin-Angiotensin System on Human Disease. Proteases in Biology and Disease, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6372-5_4

Download citation

Publish with us

Policies and ethics

Search

Navigation