Features of Somatic Gene Mutagenesis in Different Age Groups of Persons Exposed to Low Dose Radiation
The aim of this work was to study the level of somatic gene mutagenesis in persons exposed to ionizing radiation at doses up to 200 mSv and determine features of this process in different age groups. Frequency of lymphocytes bearing mutations at T-cell receptor (TCR) locus was assessed by flow cytometry in 1386 persons, including 215 unexposed control donors, in 1995–2005.
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- Cole, J. and Scopek, T.R., 1994, Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo, Mutat. Res. 304: 33–105.Google Scholar
- Noppa, N., Bonassi, S., Hansten, I.-L. et al., 2006, Chromosomal aberrations and SCE as biomarkers of cancer risk, Mutat. Res. 600: 37–45.Google Scholar