Diseases involving the Golgi calcium pump

  • J. VANOEVELEN
  • L. DODE
  • L. RAEYMAEKERS
  • F. Wuytack
  • L. Missiaen
Part of the Subcellular Biochemistry book series (SCBI, volume 45)

Abstract

Secretory-pathway Ca 2+ -transport ATPases (SPCA) provide the Golgi apparatus with Ca 2+ and Mn 2+ needed for the normal functioning of this organelle. Loss of one functional copy of the human SPCA1 gene (ATP2C1) causes Hailey-Hailey disease, a rare skin disorder characterized by recurrent blisters and erosions in the flexural areas. Here, we will review the properties and functional role of the SPCAs. The relationship between Hailey-Hailey disease and its defective gene (ATP2C1) will be adressed as well

Keywords

SPCA ATP2C1 ATP2C2 Hailey-Hailey disease Golgi apparatus 

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Copyright information

© Springer 2007

Authors and Affiliations

  • J. VANOEVELEN
    • 1
  • L. DODE
    • 1
  • L. RAEYMAEKERS
    • 1
  • F. Wuytack
    • 1
  • L. Missiaen
    • 1
  1. 1.Laboratory of PhysiologyKULeuven Campus Gasthuisberg O&N1Herestraat 49 bus 802Belgium

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