Self-assembly of polypeptides. The effect of thermodynamic confinement
Despite common belief the most well-known polypeptide secondary structure (??–helical) is of rather low persistence. We have investigated the effect of the thermodynamic confinement produced by the unlike segments of nanophase separated block copolymers on the persistence length of ??–helices. The thermodynamic field give rise to a partial annihilation of helical defects. This suggests that thermodynamic confinement can be employed as a means of secondary structure perfection in phase separated polypeptide block copolymers.
KeywordsPolypeptides block copolymers confinement ??–helices persistence length
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