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The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis

  • Mohamed Salhab
  • Kefah Mokbel
Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 11)

Abstract

There is a large and compelling body of epidemiological and experimental evidence that oestrogens are the fuel behind the aetiology of breast cancer. The local biosynthesis of oestrogens especially in postmenopausal women as a result of the interactions of various enzymes is believed to play a very important role in the pathogenesis and development of hormone-dependent breast carcinoma. The over-expression of such enzymes seems to be associated ciated with the development of a more aggressive disease and associated with poor outcome and increased local and distant recurrences. In this chapter we shed light on CYP19 gene expression, aromatase enzyme activity and its role in mammary carcinogenesis. In addition, other oestrogen producing enzymes such as 17beta hydroxysteroid dehydrogenase 1, 2 and steroid sulphatase and their role in breast cancer development are these enzymes is crucial to the development of new endocrine preventative and therapeutic strategies in postmenopausal females with hormonedependant breast cancer. Currently, the third generation of aromatase dependant breast cancer. Currently, the third generation of aromatase inhibitors has revolutionised the treatment of oestrogen-dependant breast cancer. However, the important role of both STS and 17beta HSD type 1 therapy. Such endocrine therapy is currently being explored and the development of STS inhibitors and 17beta HSD 1 inhibitors is underway with promising initial results.

Keywords

breast cancer estrogen postmenopausal aromatase 17beta HSD type 1 steroid sulphatase carcinogenesis 

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References

  1. 1.
    Henderson IC, Canellos GP. Cancer of the breast: The past decade. N Engl J Med 1990; 302:17-30.Google Scholar
  2. 2.
    Henderson HS, Ross RK, Bernstein L. Oestrogens as a cause of human Cancer. The Richard and Hinda Rosenthal Foundation award Lecture. Cancer Research 1988; 48:246.PubMedGoogle Scholar
  3. 3.
    Page DL, Dupont WD, Rogers LW, Rados MS. Atypical hyperplastic lesions of the female breast; a longterm follow-up study. Cancer 1985; 55:2698-2708.PubMedGoogle Scholar
  4. 4.
    London SJ, Connolly JL, Schnitt SJ, Colditz GA. A prospective study of benign breast disease and the risk of breast cancer. JAMA. 1992; 267:941-944.PubMedGoogle Scholar
  5. 5.
    Shekhar PVM, Werdell J, Barsrur VS. Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. J Natl Cancer Inst 1997; 89:1774-1782.PubMedGoogle Scholar
  6. 6.
    Dao TL. The role of the ovarian steroid hormones in mammary carcinogenesis. In Pike, MC, Siiteri PK, and Welsch, CW (eds) Hormones and breast cancer. (anbury repport no.8). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1981; pp. 281-295.Google Scholar
  7. 7.
    Pietras RJ, Marquez DC, Chen HW, Tsai E, Weinberg O, Fishbein M. Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells. Steroids. 2005; 70:372-381.PubMedGoogle Scholar
  8. 8.
    Garvin S, Nilsson UW, Dabrosin C. Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells. Br J Cancer 2005; 93:1005-1010.PubMedGoogle Scholar
  9. 9.
    Redeuilh G, Attia A, Mester J, Sabbah M. Transcriptional activation by the oestrogen receptor alpha is modulated through inhibition of cyclin-dependent kinases. Oncogene 2002; 21:5773-5782.PubMedGoogle Scholar
  10. 10.
    Yue W, Wang JP, Hamilton CJ, Demers LM, Santen RJ. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res 1998; 58:927-932.PubMedGoogle Scholar
  11. 11.
    Sasano H. Okamoto M, Mason JI, Simpson ER, Mendelson CR, Sasano N, Silverberg SG. Immunolocalization of aromatase, 17 alpha-hydroxylase and sidechain-cleavage cytochromes P-450 in the human ovary. Journal of Reproduction & Fertility 1989; 85:163-169.CrossRefGoogle Scholar
  12. 12.
    Sasano H. Functional pathology of human ovarian steroidogenesis: Normal cycling ovary and steroidproducing neoplasms. Endocrine Pathology 1994; 5: 81-89.Google Scholar
  13. 13.
    Labrie F, Luu-The V, Labrie C, Belanger A, Simard J, Lin SX, Pelletier G. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocrine Reviews 2003; 24:152-182.PubMedGoogle Scholar
  14. 14.
    Berrino F, Muti P, Micheli A, Bolelli G, Krogh V, Sciajno R, Pisani P, Panico S, Secreto G. Serum sex hormone levels after menopause and subsequent breast cancer. J Natl Cancer Inst 1996; 88:291-296.PubMedGoogle Scholar
  15. 15.
    Lipworth L, Adami HO, Trichopoulos D, Carlstrom K, Mantzoros C. Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the etiology of postmenopausal breast cancer. Epidemiology 1996; 7:96-100.PubMedGoogle Scholar
  16. 16.
    Dorgan JF, Stanczyk FZ, Longcope C, Stephenson Jr HE, Chang L, Miller R, Franz C, Falk RT, Kahle L. Relationship of serum dehydroepiandrosterone (DHEA), DHEA sulfate, and 5-androstene-3 beta, 17 beta-diol to risk of breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 1997; 6:177-181.PubMedGoogle Scholar
  17. 17.
    Sasano H, Harada N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocrine Reviews 1998; 19:593-607.PubMedGoogle Scholar
  18. 18.
    Miller WR. Aromatase activity in breast tissue. J Steroid Biochem Mol Biol 1991; 39:783-790.PubMedGoogle Scholar
  19. 19.
    Schweikert HU, Milewich L, Wilson JD. Aromatization of androstenedione by cultured human fibroblasts. J Clin Endocrinol Metab 1976; 43:785-795.PubMedGoogle Scholar
  20. 20.
    Longcope C, Pratt JH, Schneider SN, Fineberg SE. Aromatization of androgens by muscle and adipose tissue in vivo. J Clin Endocrinol Metab 1978; 46:146-152.PubMedGoogle Scholar
  21. 21.
    Sasano H, Uzuki M, Sawai T, Nagura H, Matsunaga G, Kashimoto O, Harada N. Aromatase in human bone tissue. J Bone Miner Res 1997; 12:1416-1423.PubMedGoogle Scholar
  22. 22.
    Santner SJ, Chen S, Zhou D, Korsunsky Z, Martel J, Santen RJ. Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture. J Steroid Biochem Mol Biol 1993; 44:611-616.PubMedGoogle Scholar
  23. 23.
    Chetrite GS, Cortes-Prieto J, Philippe JC, Wright F, Pasqualini JR. Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J Steroid Biochem Mol Bio 2000; 72: 23-27.Google Scholar
  24. 24.
    Pasqualini JR, Chetrite G, Blacker C, Feinstein MC, Delalonde L, Talbi M, Maloche C. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. Clin Endocr Metab 1996; 81:1460-1464.Google Scholar
  25. 25.
    Pasqualini JR. The selective estrogen enzyme modulators in breast cancer: a review. Biochimica et Biophysica Acta 2004; 1654:123-143.PubMedGoogle Scholar
  26. 26.
    Reed MJ, Owen AM, Lai LC, Coldham NG, Ghilchik MW, Shaikh NA, James VHT. In situ oestrone synthesis in normal breast and breast tumour tissues: effect of treatment with 4-hydroxyandrostenedione. Int J Cancer 1989; 44:233-237.PubMedGoogle Scholar
  27. 27.
    Reed MJ, Purohit A, Howarth NM, Potter BVL. Steroid sulphatase inhibitors: a new endocrine therapy. Drugs Future 1994; 19:673-680.Google Scholar
  28. 28.
    Miyoshi Y, Ando A, Hasegawa S, Ishitobi M, Taguchi T, Tamaki Y, Noguchi S. High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. Clin Cancer Res 2003; 9:2288-2293PubMedGoogle Scholar
  29. 29.
    Nelson DR, Koymans L, Kamataki T, stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 1996; 6:1-42.PubMedGoogle Scholar
  30. 30.
    Chen SA, Besman MJ, Sparkes RS, Zollman S, Klisak I, Mohandas T, Hall PF, Shively JE. Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to chromosome 15. DNA 1988; 7:27-38.PubMedGoogle Scholar
  31. 31.
    Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD, Mendelson CR, Bulun SE. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 1994; 15:342-355.PubMedGoogle Scholar
  32. 32.
    Simpson ER. Sources of estrogen and their importance. J Steroid Biochem Mol Biol 2003; 86:225-230.PubMedGoogle Scholar
  33. 33.
    Nelson LR, Bulun SE. Estrogen production and action. J Am Acad Dermatol 2001; 45:116-124.Google Scholar
  34. 34.
    Simpson ER, Davis SR. Minireview. Aromatase and the regulation of estrogen biosynthesis- some new perspectives. Endocrinology 2001; 142:4589-4594.PubMedGoogle Scholar
  35. 35.
    Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Corbin CJ, Mendelson CR. Tissue specific promoters regulate aromatase cytochrome P450 expression. J Steroid Biochem Mol Biol 1993; 44:321-330.PubMedGoogle Scholar
  36. 36.
    Sebastian S, Bulun SE. A highly complex organization of the regulatory region of the human CYP 19 (Aromatase) gene revealed by the Human Genome Project. J Clin Endocrinol Metab 2001; 86:4600-4602.PubMedGoogle Scholar
  37. 37.
    Sebastian S, Takayama K, Shozu M, Bulun SE. Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is upregulated in breast cancer tissue Mol Endocrinol 2002; 16:2243-2254.PubMedGoogle Scholar
  38. 38.
    Harada N. A unique aromatase (P-450arom) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts. Biochem Biophys Res Commun 1993; 189:1001-1007.Google Scholar
  39. 39.
    Zhou C, Zhou D, Esteban J, Murai J, Siiteri PK, Wilczynski S, Chen S. Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction (RT-PCR). J Steroid Biochem Mol Biol 1996; 59:163-171.PubMedGoogle Scholar
  40. 40.
    Bulun SE, Noble LS, Takayama K, Michael MD, Agarwal V, Fisher C, Zhao Y, Hinshelwood MM, Ito Y, Simpson ER. Endocrine disorders associated with inappropriately high.aromatase expression. J Steroid Biochem Mol Biol 1997; 61: 133-139.PubMedGoogle Scholar
  41. 41.
    Simpson ER, Michael MD, Agarwal VR, Hinshelwood MM, Bulun SE, Zhao Y. Cytochromes P450 11: expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage. FASEB J 1997; 11:29-36.PubMedGoogle Scholar
  42. 42.
    Harada N, Utsumi T, Takagi Y. Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissuespecific exons 1 in carcinogenesis. Proc Natl Acad Sci USA 1993; 90:11312-11316.PubMedGoogle Scholar
  43. 43.
    Esteban JM, Warsi Z, Haniu M, Hall P, Shively JE, Chen S. Detection of intratumoral aromatase in breast carcinomas. Am J Pathol 1992; 140:337-343.PubMedGoogle Scholar
  44. 44.
    Purohit A, Ghilchik MW, Duncan LJ, Wang DY, Singh A, Walker MM, Reed MJ. Aromatase activity and interleukin 6 production by normal and malignant breast tissues. J Clin Endocrinol Metab 1995; 80:3052-3058.PubMedGoogle Scholar
  45. 45.
    Singh A, Purohit A, Duncan LJ, Mokbel K, Ghilchik MW, Reed MJ. Control of aromatase in breast tumours: the role of the immune system. J Steroid Biochem Mol Biol 1997; 61:185-192.PubMedGoogle Scholar
  46. 46.
    Reed MJ, Coldham NG, Patel SR, Ghilchik MW, James VHT. Interleukin-1 and interleukin-6 in breast cyst fluid: their role in regulating aromatase activity in breast cancer cells. J Endocrinol 1992, 132:R5-R8.PubMedGoogle Scholar
  47. 47.
    Reed MJ, Purohit A. Sulphatase inhibitors: the rationale for the development of a new endocrine therapy. Rev Endocr Rel Cancer 1993; 45:51-62.Google Scholar
  48. 48.
    Miller WR, Mullen P. Factors influencing aromatase activity in the breast. J Steroid Biochem Molec Biol 1993; 44:597-604.PubMedGoogle Scholar
  49. 49.
    Zhao Y, Nichols JE, Bulnn SE, Mendelson CR, Simpson ER. Aromatase P450 gene expression in human adipose tissue. J Biol Chem 1995, 270:16449-16457.PubMedGoogle Scholar
  50. 50.
    Singh A, Purohit A, Wang DY, Duncan LJ, Ghilchik MW, Reed MJ. IL-6sR: release from MCF-7 breast cancer cells and role in regulating peripheral oestrogen synthesis. J Endocrinol 1995; 147:R9-R12.PubMedGoogle Scholar
  51. 51.
    Macdiarmid F, Wang DY, Duncan LJ, Purohit A, Ghilchik MW, Reed MJ. Stimulation of aromatase activity in breast fibroblasts by tumour necrosis factor ʱ Molec Cell Endocr 1994; 106:17-21.Google Scholar
  52. 52.
    Agarwal V, Bulun SE, Leitch M, Rohrich R, Simpson ER. Use of alternative promoters to express the aromatase P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J Clin Endocrinol Metab 1996; 81:3843-3849.PubMedGoogle Scholar
  53. 53.
    Zhao Y, Agarwal VR, Mendelsohn CR, Simpson ER. Transcriptional regulation of CYP19 (aromatase) gene expression in adipose stromal cells in primary culture. J Steroid Biochem Mol Biol 1997; 61 (3-6) 203-210.PubMedGoogle Scholar
  54. 54.
    Singh A, Purohit A, Ghilchik MW, Reed MJ. The regulation of aromatase activity in breast fibroblasts: the role of interleukin- 6 and prostaglandin E2. Endocr-Relat Cancer 1999; 6:139-147.PubMedGoogle Scholar
  55. 55.
    Miller WR, O’Neill JS. The importance of local synthesis of estrogen within the breast. Steroids 1987; 50:537-547.PubMedGoogle Scholar
  56. 56.
    Bulun SE, Price TM, Aitken J, Mahendroo MS, Simpson ER. A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab 1993; 77:1622-1628.PubMedGoogle Scholar
  57. 57.
    Utsumi T, Harada N, Maruta M, Takagi Y. Presence of alternatively spliced transcripts of aromatase gene in human breast cancer. J Clin Endocrinol Metab 1996; 81:2344-2349.PubMedGoogle Scholar
  58. 58.
    James VHT, McNeill JM, Lai LC, Newton CJ, Ghilchik MW, Reed MJ. Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies. Steroids 1987; 50:269-279.PubMedGoogle Scholar
  59. 59.
    Zhou D, Pompon D, Chen S. Stable expression of human aromatase cDNA in mammalian cells - A useful system for aromatase inhibitor screening. Cancer Res 1990; 50:6949-6954.PubMedGoogle Scholar
  60. 60.
    Yue W, Zhou D, Chen S, Brodie A. A new nude mouse model for postmeno- pausal breast cancer using MCF-7 cells transfected with the htmmn aromatase gene. Cancer Res 1994; 54:5092-5095.PubMedGoogle Scholar
  61. 61.
    Macaulay VM, Nicholls JE, Gledhi UJ, Rowlands MG, Dowsett M, Ashworth A. Biological effects of stable overexpression of aromatase in human hormone- dependent breast cancer ceils. Br J Cancer 1994; 69:77-83.PubMedGoogle Scholar
  62. 62.
    Salhab M, Reed MJ, Al Sarakbi W, Jiang WG, Mokbel K. The role of aromatase and 17-beta hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer. Breast Cancer Res Treat 2006; 99(2):155-162. Epub 2006 Mar 16.PubMedGoogle Scholar
  63. 63.
    Miller WR, Anderson TJ, Lack WJL. Relationship between tumor aromatase activity, tumor characteristics and response to therapy. Steroid Biochem Molec Biol 1990; 37:1055-1059.Google Scholar
  64. 64.
    Sasano H, Nagura H, Harada N, Goukon Y, Kimyra M. Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hure Pathol 1994; 25:530-535.Google Scholar
  65. 65.
    Zhang Z, Yamashita H, Toyama T, Hara Y, Omoto Y, Sugiura H, Kobayashi S, Harada N, Iwase H. Semi quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast. Breast Cancer Res Treat Treat 2002; 74:47-53.Google Scholar
  66. 66.
    Brodie A, Lu Q, Nakamura J. Aromatase in the normal breast and breast cancer. J Steroid Biochem Mol Biol 1997; 61:281-286.PubMedGoogle Scholar
  67. 67.
    The ATAC (Arimidex Tamoxifen alone or in Combination) Trialists’ Group, Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial Lancet 2002; 359:2131-2139.Google Scholar
  68. 68.
    Cunnick GH, Mokbel K. Aromatase inhibitors. Curr Med Res Opin 2001; 17: 217-22.PubMedGoogle Scholar
  69. 69.
    Mokbel K. The evolving role of aromatase inhibitors in breast cancer. Int J Clin Oncol 2002; 7:279-283.PubMedGoogle Scholar
  70. 70.
    Luu-The V, Labrie C, Zhao HF, Couet J, Lachance Y, Simard J, Leblanc G, Cote J, Berube D, Gagne R, Labrie F. Characterization of cDNAs for human estradiol 17beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 50 -termini in human placenta. Molecular Endocrinology 1989; 3:1301-1309.PubMedGoogle Scholar
  71. 71.
    Miettinen MM, Mustonen MVJ, Poutanen MH, Isomaa VV, Vihko RK. Human 17b-hydroxysteroid dehydrogenase type 1 and type 2 isozymes have opposite activities in cultured cells and characteristic celland tissue-specific expression. Biochem J 1996; 314:839-845.PubMedGoogle Scholar
  72. 72.
    Gunnarsson C, Ahnstrom M, Kirschner K, Olsson B, Nordenskjold B, Rutqvist LE, Skoog L, Stal O. Amplification of HSD17B1 and ERBB2 in primary breast cancer. Oncogene 2003; 22:34-40.PubMedGoogle Scholar
  73. 73.
    Takeyama J, Sasano H, Suzuki T, Iinuma K, Nagura H, Andersson S. 17Beta- hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development. J Clin Endocrin Metabol 1998; 83:3710-3715.Google Scholar
  74. 74.
    Takeyama J, Suzuki T, Hirasawa G, Muramatsu Y, Nagura H, Iinuma K, Nakamura J, Kimura KI, Yoshihama M, Harada N, Andersson S, Sasano H. 17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus. J Clin Endocrinol Metabol 2000; 85:410-416.Google Scholar
  75. 75.
    Adams EF, Rafferty B, White MC. Interleukin-6 is secreted by breast fibroblasts and stimulates 17beta oxidoreductase activity in MCF-7 breast cancer cells: possible paracrine regulation of 17beta oestradiol levels. Int J Cancer 1991; 49:118-121.PubMedGoogle Scholar
  76. 76.
    Duncan LJ, Coldham NG, Reed MJ. The interaction of cytokines in regulating oestradiol 17beta hydroxysteroid dehydrogenase activity in MCF-7 cells. J Steroid Biochem Mol Biol 1994; 49:63-68.PubMedGoogle Scholar
  77. 77.
    Singh A, Blench I, Morris HR, Savoy L-A, Reed MJ. Synergistic interaction of growth factors and albumin in regulating estrogen synthesis in breast cancer cells. Mol Cell Endocrinol 1992; 85:165-173.PubMedGoogle Scholar
  78. 78.
    Miller WR, Hawkins RA, Forrest APM. Significance of aromatase activity in human breast cancer. Cancer Res 1982; 42:3365-3368.Google Scholar
  79. 79.
    Perel E, Wilkins D, Killinger DW. The conversion of androstenedione to estrone, estradiol and testosterone in breast tissue. J Steroid Biochem, 1980; 13:89-94.PubMedGoogle Scholar
  80. 80.
    Suzuki T, Moriya T, Ariga N, Kaneko C, Kanazawa M, Sasano H. 17Beta- hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Br J Cancer 2000; 82:518-523.PubMedGoogle Scholar
  81. 81.
    Sasano H, Frost AR, Saitoh R, Harada N, Poutanen M, Vihko R, Buhm SE, Silverberg SG, Nagura H. Aromatase and 17beta hydroxysteroid dehydrogenase type 1 in human breast carcinoma. J Clin Endocrinol Metab 1996; 11:4042-4046.Google Scholar
  82. 82.
    Suzuki T, Nakata T, Miki Y, Kaneko C, Moriya T, Ishida T, Akinaga S, Hirakawa H, Kimura M, Sasano H. Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Cancer Res 2003; 63:2762-2770.PubMedGoogle Scholar
  83. 83.
    Ariga N, Moriya T, Suzuki T, Kimura M, Ohuchi N, Satomi S, Sasano H. 17 beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast. Anticancer Res 2000; 20:1101-1108.PubMedGoogle Scholar
  84. 84.
    Oduwole OO, Li Y, Isomaa VV, Mantyniemi A, Pulkka AE, Soini Y, Vihko PT. 17beta-hydroxysteroid dehydrogenase type 1 is an independent prognostic marker in breast cancer. Cancer Res 2004; 64:7604-7609.PubMedGoogle Scholar
  85. 85.
    Zhang Z, Yamashita H, Toyama T, Omoto Y, Sugiura H, Hara Y, Wu X, Kobayashi S, Iwase H. Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast. Breast Cancer Res 2003; 5:250-256.Google Scholar
  86. 86.
    Gunnarsson C, Olsson BM, Stal O. Southeast Sweden Breast Cancer GroupAbnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence. Cancer Res. 2001; 61:8448-8451.PubMedGoogle Scholar
  87. 87.
    Feigelson, SH, McKean-Cowdin, R, Coetzee, GA, Stram, DO, Kolonel, LN, and Henderson, BE. Building a multigenic model of breast cancer susceptibility: CYP 17 and HSD 17 beta 1 are two important candidates. Cancer Res 2001; 61:785-789.PubMedGoogle Scholar
  88. 88.
    Fischer DS, Allan GM, Bubert C, Vicker N, Smith A, Tutill HJ, Purohit A, Wood L, Packham G, Mahon MF, Reed MJ, Potter BV. E-ring modified steroids as novel potent inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1. J Med Chem 2005; 48:5749-5770.PubMedGoogle Scholar
  89. 89.
    Bond CS, Clements PR, Ashby SJ, Collyer CA, Harrop SJ, Hopwood JJ, Guss JM. Structure of a human lysosomal sulfatase. Structure 1997; 5:277-289.PubMedGoogle Scholar
  90. 90.
    Ferrante P, Messali S, Meroni G, Ballabio A. Molecular and biochemical characterisation of a novel sulphatase gene: aryl sulphatase G (ARSG). Eur J Hum Genet 2002; 10:813-818.PubMedGoogle Scholar
  91. 91.
    Yen PH, Marsh B, Allen E, Tsai SP, Ellison J, Connoly L, Neiswanger K, Shapiro LJ. The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. Cell 1988; 55:1123-1135.PubMedGoogle Scholar
  92. 92.
    Reed MJ, Purohit A, Woo LW, Newman SP, Potter BV. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr Rev 2005; 26(2):171-202.PubMedGoogle Scholar
  93. 93.
    Purohit A, Reed MJ. Oestrogen sulphatase activity in hormone-dependent and hormone-independent breast cancer cells: modulation by steroidal and nonsteroidal therapeutic agents. Int J Cancer 1992; 50:901-905.PubMedGoogle Scholar
  94. 94.
    Newman SP, Purohit A, Ghilchik MW, Potter BVL, Reed MJ. Regulation of steroid sulphatase expression and activity in breast cancer. J Steroid Biochem Mol Biol 2000; 75:259-264.PubMedGoogle Scholar
  95. 95.
    Pasqualini JR, Maloche C, Maroni M, Chetrite G. Effect of the progestagen Promegestone (R-5020) on mRNA of the oestrone sulphatase in the MCF-7 human mammary cancer cells. Anticancer Res 1994; 14:1589-1594.PubMedGoogle Scholar
  96. 96.
    Reed MJ. The role of aromatase in breast tumors. Breast Cancer Res Treat 1994; 30:7-17.PubMedGoogle Scholar
  97. 97.
    Reed MJ, Purohit A, Woo LWL, Potter BVL. The development of steroid sulphatase inhibitors. Endocr Rel Cancer 1996; 3:9-23.Google Scholar
  98. 98.
    Reed MJ, Topping L, Coldham NG, Purohit A, Ghilchik MW, James VHT. Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors. J Steroid Biochem Mol Biol 1993; 44:589-596.PubMedGoogle Scholar
  99. 99.
    Reed MJ, Purohit A. Inhibition of steroid sulphatases. In: Sandler M, Smith HJ, eds. Design of enzyme inhibitors as drugs, vol. 2. Oxford: Oxford University Press 1994; 481-494.Google Scholar
  100. 100.
    Basler E, Grompe M, Parenti G, Yates J, Ballabio A. Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. Am J Hum Genet 1992; 50:483-491.PubMedGoogle Scholar
  101. 101.
    Alperin ES, Shapiro LJ. Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. J Biol Chem 1997; 272:20756-20763.PubMedGoogle Scholar
  102. 102.
    Poortman J, Andriesse R, Agema A, Douker GH, Schwarz F, Thijssen JHH. Adrenal androgen secretion and metabolism in postmenopausal women. In: Genazzani AR, Thijssen JHH, Siiteri PK, eds. Adrenal androgens. Raven Press, New York, 1980; 219-240.Google Scholar
  103. 103.
    Poulin R, Labrie F. Stimulation of cell proliferation and estrogenic response by adrenal C19- delta 5-steroids in the ZR-75-1 human breast cancer cell line. Cancer Res 1986; 46:4933-4937.PubMedGoogle Scholar
  104. 104.
    Maggiolini M, Donze O, Jeannin E, Ando S, Picard D. Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha. Cancer Res 1999; 59:4864-4869.PubMedGoogle Scholar
  105. 105.
    Morris KT, Toth-Fejel SE, Schmidt J, Fletcher WS, Pommier RF. High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy. Surgery 2001; 130:947-953.PubMedGoogle Scholar
  106. 106.
    Utsumi T, Yoshimura N, Takeuchi S, Maruta M, Maeda K, Harada N. Elevated steroid sulfatase expression in breast cancer. J Steroid Biochem Mol Biol 2000; 73:141-145.PubMedGoogle Scholar
  107. 107.
    Evans TR, Rowlands MG, Law M, Coombes RC. Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma. Br J Cancer 1994; 69:555-561.PubMedGoogle Scholar
  108. 108.
    Utsumi T, Yoshimura N, Takeuchi S, Ando J, Maruta M, Maeda K, Harada N. Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. Cancer Res 1999; 59:377-381.PubMedGoogle Scholar
  109. 109.
    Al Sarakbi W, Mokbel R, Salhab M, Jiang WG, Reed MJ, Mokbel K. The Role of STS and OATP-B mRNA Expression in Predicting the Clinical Outcome in Human Breast Cancer. Anticancer Research 2006; 26 (In Press)Google Scholar
  110. 110.
    Selcer KW, Hegde PV, Li PK. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyra- mines. Cancer Res 1997; 57:702-707.PubMedGoogle Scholar
  111. 111.
    Nakata T, Takashima S, Shiotsu Y, Murakata C, Ishida H, Akinaga S, Li PK, Sasano H, Suzuki T, Saeki T. Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients. J Steroid Biochem Mol Biol 2003; 86:455-460.PubMedGoogle Scholar
  112. 112.
    Mokbel R, Karat I, Mokbel K. Adjuvant endocrine therapy for postmenopausal breast cancer in the era of aromatase inhibitors: an update. Int Semin Surg Oncol 2006; 3:31.PubMedGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Mohamed Salhab
    • 1
  • Kefah Mokbel
    • 2
  1. 1.St. George's HospitalUK
  2. 2.The Princess Grace HospitalUK

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