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Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity

  • Mary J.C. Hendrix
  • Jun Luo
  • Elisabeth A. Seftor
  • Navesh Sharma
  • Paul M. HeidgerJr.
  • Michael B. Cohen
  • Robert Bhatty
  • Jirapat Chungthapong
  • Richard E.B. Seftor
  • David Lubaroff
Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 10)

Abstract

Tumor cell plasticity poses a significant clinical challenge in that the fate and function of tumor cells can be elusive until a tumor mass is evident. An overview of key molecular events in prostate cancer, initiated by an epithelial-to-mesenchymal transition, highlights the cooperative interactions of diverse prostatic subpopulations within heterogeneous tumors. A remarkable example of plasticity is demonstrated by subpopulations of E-cadherin-positive and E-cadherin-negative tumor cells working in concert to form de novo vasculogenic-like networks while expressing vascular-associated genes, called vasculogenic mimicry, resulting in acquisition of the metastatic phenotype. A better understanding of the molecular mechanisms underlying prostate tumor cell plasticity may provide new prognostic markers for clinical diagnosis and novel therapeutic intervention strategies for disease management.

Keywords

prostate cancer plasticity E-cadherin epithelial-mesenchymal transition 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Mary J.C. Hendrix
    • 1
    • 4
  • Jun Luo
    • 5
  • Elisabeth A. Seftor
    • 1
    • 4
  • Navesh Sharma
    • 1
    • 6
  • Paul M. HeidgerJr.
    • 1
    • 4
  • Michael B. Cohen
    • 2
    • 4
  • Robert Bhatty
    • 1
  • Jirapat Chungthapong
    • 1
  • Richard E.B. Seftor
    • 1
    • 4
  • David Lubaroff
    • 3
    • 4
  1. 1.Departments of Anatomy and Cell BiologyUniversity of IowaIowa CityUSA
  2. 2.Pathology, University of IowaIowa CityUSA
  3. 3.Urology, College of MedicineUniversity of IowaIowa CityUSA
  4. 4.The Holden Comprehensive Cancer CenterUniversity of IowaIowa CityUSA
  5. 5.Brady Urological InstituteJohns Hopkins Medical InstitutionsBaltimoreUSA
  6. 6.University Health SciencesCollege of Osteopathic MedicineKansas CityUSA

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