Abstract
All hominid molars show the same sequence of cusp initiation, but differ in the later stages of development. The topography of the dentin-enamel junction (DEJ) represents the outcome of differential growth between cusps. Since the cusps grow in an orderly sequence from tip to base (defined by the plane of coalescence with adjacent cusps), quantification of cusp volume and relationships can be used to reconstruct successive stages in development and their contribution to the morphometry of the crown surface. Their volume and spatial relationships at the DEJ enable us to partition cell proliferation in relation to cusp initiation, while quantification of the amount and distrib ution of enamel overlying the DEJ provides the necessary discrimination between cell proliferation and cell function, expressed in enamel matrix apposition. We have developed a three-dimensional computerized model of a lower molar tooth that enables us to identify and quantify the different stages of tooth development defined above. The model is based on serial micro-computed tomography (microCT) images of human teeth that provide accurate quantification of the outer and inner enamel and dentin boundaries of individual cusps. We have used this model to compare morphogenesis in the lower second deciduous molar and lower first permanent molar. Spatial relationships of the cusps, expressed by the topography of the DEJ showed that shape differences were established in the early stages of morphogenesis by differential proliferation within the developing tooth germ and that cusp size and proportions were modified at the crown surface by enamel apposition. Reduction of the hypoconulid in the permanent molar shown at the DEJ was largely masked by the exceptional thickness of enamel on this cusp. We propose that this model provides a novel contribution to the identification of ontogenetic trajectories and their contribution to evolutionary trends in tooth size, shape and enamel thickness.
Keywords
- evolutionary-development
- tooth development
- morphogenesis
- microCT
- DEJ
- morphometry
- enamel thickness
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References
Avishai, G., Muller, R., Gabet, Y., Bab, I., Zilberman, U., Smith, P., 2004. New approach to quantifying developmental variation in the dentition using serial micro tomographic imaging. Microscopy Research Techniques 65(6), 263–269.
Butler, P. M., 1967. Comparison of the development of the second deciduous molar and first permanent molar in man. Archives of Oral Biology 12(11), 1245–1260.
Butler, P. M., 1968. Growth of the human second lower deciduous molar. Archives of Oral Biology 13(6), 671–682.
Butler, P.M., 1999. The relation of cusp development and calcification to growth. In: Mayhall, J.T., Heikkinen, T. (Eds.),Dental Morphology 1998: Proceedings of the 11th International Symposium on Dental Morphology. Oulo University Press, Oulu,Finland, pp. 26–32.
Collard, M., Wood, B., 2000. How reliable are human phylogenetic hypotheses? Proceedings of the National Academy of Sciences of the USA 97(9), 5003–5006.
Dahlberg, A., 1945. The changing dentition of man. Journal of the American Dental Association 32, 676–690.
Finarelli, J.A., Clyde, W.C., 2004. Reassessing hominoidphylogeny: evaluating congruence in the morphological and temporaldata. Paleobiology 30(4), 614–651.
Gabet, Y., Muller, R., Regev, E., Sela, J., Shteyer, A., Salisbury, K., Chorev, M., Bab, I., 2004. Osteogenic growthpeptide modulates fracture callus structural and mechanical properties. Bone 3(1), 65–73.
Gregory, W.K., Hellman, M., 1926. The Dentition of Drypopithecus and the Origin of Man. Anthropology Papers of the American Museum of Natural History New York 28, 1–123.
Grine, F., 2005. Enamel thickness of deciduous and permanent molars in modern Homo sapiens. American Journal of Physical Anthropology 126(1), 14–31.
Hlusko, L.J., 2004. Integrating the genotype and phenotype in hominid paleontology. Proceedings of the National Academy ofSciences of the USA 101(9), 2653–2657.
Jernvall, J., 2000. Linking development with generation of novelty in mammalian teeth. Proceedings of the National Academy of Sciences of the USA 97(6), 2641–2645.
Jernvall, J., Keranen, S.V., Thesleff, I., 2000. Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography. Proceedings of the National Academy of Sciences of the USA 97(26), 14444–14448.
Korenhof, C.A., 1960. Morphogenetic aspects of the human uppermolar. A comparative study of the enamel and dentin surfaces and their relationship to the crown pattern of fossil and recentprimates. Academisch Proefschrift, Uitg. mij Neerlandia, Utrecht.
Korenhof, C.A., 1979. The evolution of the lower molar pattern and remnants of the trigonid crests in man. Nederlandisch. Tijdschr Tandheelkd 86 (Suppl 17), 6–31.
Kraus, B.S., 1952. Morphological relationships between enamel anddentin surfaces of lower first molar tooth. Journal of Dental Research 31, 248–256.
Kraus, B.S., Jordan, R.E., 1965. The Human Dentition Before Birth. Lea & Febiger, Philadelphia.
Macho, G.A., 1995. The significance of hominid enamel thickness for phylogenetic and life-history reconstruction. In:Moggi-Cecchi, J. (Ed.), Aspects of Dental Biology: Paleontology,Anthropology and Evolution. Angelo Pontecorbi, Florence, pp.p 51–68.
McCollum, M., Sharpe, P.T., 2001. Evolution and development of teeth. Journal of Anatomy 199 (Pt 1–2), 153–159.
Müller, R., Hildebrand, T., Rüegsegger, P., 1994. Non-invasive bone biopsy: A new method to analyse and display thethree-dimensional structure of trabecular bone. Physics in Medicine and Biology 39, 145–164.
Müller, R., Van Campenhout, H., Van Damme, B., Van Der Perre,G., Dequeker, J., Hildebrand, T., Rüegsegger, P., 1998. Morphometric analysis of human bone biopsies: a quantitativestructural comparison of histological sections and micro-computed tomography. Bone 23(1), 59–66.
Peters, O. A., Laib, A., Ruegsegger, P., Barbakow, F., 2000.t Three-dimensional analysis of root canal geometry by high-resolution computed tomography. Journal of Dental Research 79(6),1405–1409.
Rüegsegger, P., Koller, B., Müller, R., 1996. Amicrotomographic system for the nondestructive evaluation of bone architecture. Calcified Tissue International 58, 24–29.
Sasaki, K., Kanazawa, E., 1999. Morphological traits on thedentino-enamel junction of lower deciduous molar series. In:Mayhall, J., Heikkinen, T. (Eds.), Dental Morphology 1998:Proceedings of the 11th International Symposium on Dental Morphology. Oulo University Press, Oulu, Finland, pp. 167–178.
Shimizu, T., Oikawa, H., Han, J., Kurose, E., Maeda, T., 2004. Genetic analysis of crown size in the first molarsusing SMXA recombinant inbred mouse strains. Journal of Dental Research 83(1), 45–49.
Smith, P., Gomorri, J. M., Spitz, S., Becker, J., 1997. Model forthe examination of evolutionary trends in tooth development. American Journal of Physical Anthropology 102(2), 283–294.
Smith, P., Gomori, J., Shaked, R., Haydenblit, R. and Joskowicz, L., 2000. A computerized approach to reconstruction of growth patternsin hominid molar teeth. In: Mayhall, J., Heikkinen, T. (Eds.),Proceedings of the 11th International Symposium on Dental morphology. Oulo University Press, Oulo, Finland, pp. 388–397.
von Stechow, D., Balto, K., Stashenko, P., Muller, R., 2003. Three-dimensional quantitation of periradicular bone destructionby micro-computed tomography. Journal of Endodonty 29(4),252–256.
Winkler, L.A., Schwartz, J.H., Swindler, D.R., 1991. Aspects of dental development in the orangutan prior to eruption of the the permanent dentition. American Journal of Physical Anthropology 86(2), 255–273.
Zhao, Z., Weiss, K.M. and Stock, D.W., 2000. Development and evolution of dentition patterns and their genetic basis. In:Teaford, M.F., Smith, M.M., Ferguson, M.W.J. (Eds.), Development Function and Evolution of Teeth. Cambridge University Press, Cambridge, pp. 152–172.
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Smith, P., Müller, R., Gabet, Y., Avishai, G. (2007). A computerized model for reconstruction of dental ontogeny: A new tool for studying evolutionary trends in the dentition. In: Bailey, S.E., Hublin, JJ. (eds) Dental Perspectives on Human Evolution: State of the Art Research in Dental Paleoanthropology. Vertebrate Paleobiology and Paleoanthropology. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5845-5_19
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DOI: https://doi.org/10.1007/978-1-4020-5845-5_19
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