Of mice and monkeys: Quantitative genetic analyses of size variation along the dental arcade
We present preliminary results from quantitative genetic analyses of tooth size variation in two outbred pedigreed populations, baboons and mice. These analyses were designed to test the dental field theory as proposed by Butler (1939), that there are three fields within the dentition: incisor, canine, and molar. Specifically we estimated the genetic correlation between pairs of linear size measurements. Results from the baboon analyses suggest that there may also be a premolar field that is only partially independent of the molar field proposed by Butler (1939). Analyses of the mouse data indicate that for mice, size variation in the incisors appears to be genetically independent of molar size. If the field theory is correct, future analyses on incisor data for the baboons will return similar results of genetic independence. Circumstantial evidence from the fossil record suggests that there will be at least some degree of independence between the anterior and postcanine dentitions of primates.
Keywordsquantitative genetics dental fields field theory dental patterning Papio hamadryas Mus
Unable to display preview. Download preview PDF.
- Boehnke, M., Moll, P.P., Kottke, B.A., Weidman, W.H., 1987. Partitioning the variability of fasting plasma glucose levels inpedigrees. Genetic and environmental factors. American Journal ofEpidemiology 125, 679–689.Google Scholar
- Butler, P.M., 1939. Studies of the mammalian dentition –differentiation of the postcanine dentition. Proceedings of theZoological Society of London, Series B 109, 1–36.Google Scholar
- Dyke, B., 1996. PEDSYS: A Pedigree Database Management System Users Manual. Population Genetics Laboratory, Department of Genetics, Southwest Foundation for Biomedical Research, SanAntonio, TXGoogle Scholar
- Hlusko, L.J., Maas, M.L., Mahaney, M.C., 2004a. Statistical geneticsof molar cusp patterning in pedigreed baboons: Implications forprimate dental development and evolution. Molecular andDevelopmental Evolution (Journal of Experimental Zoology) 302B,268–283.Google Scholar
- Huxley, J.S., de Beer, G.R., 1934. The Elements ofExperimental Embryology. Cambridge University Press, Cambridge.Google Scholar
- Jernvall, J., Thesleff, I., 2000. Reiterative signaling andpatterning during mammalian tooth morphogenesis. Mechanisms ofDevelopment 92, 19–29.Google Scholar
- Lynch, M., Walsh, B., 1998. Genetics and Analysis of Quantitative Traits. Sinauer Associates, Inc., Sunderland, MA.Google Scholar
- National Research Council., 1996. Guide for Care and Use of Laboratory Animals. National Academy of Sciences, Washington, D.C.Google Scholar
- Nowak, R.M., 1991. Walker’s Mammals of the World, 5th Edition,Volume II. The Johns Hopkins University Press, Baltimore, MD.Google Scholar