Analysis of Large-Scale mRNA Expression Data Sets by Genetic Algorithms

  • Chia Huey Ooi
  • Patrick Tan
Part of the Computational Biology book series (COBO, volume 5)

DNA microarray experiments typically produce large-scale data sets comprising thousands of mRNA expression values measured across multiple biological samples. A common problem in the analysis of this data is the ‘curse of dimensionality’, where the number of available samples is often insufficient for reliable analysis due to the large number of individual measurements made per sample. Genetic algorithms (GAs) are a promising approach towards addressing this problem. Here, several examples from the scientific literature are discussed to illustrate the various ways GAs have been applied to the analysis of mRNA expression data sets, specifically in the area of cancer classification.


Europe Lymphoma Leukemia Covariance Oncol 


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Copyright information

© Springer 2004

Authors and Affiliations

  • Chia Huey Ooi
    • 1
  • Patrick Tan
    • 2
  1. 1.National Cancer CentreSingapore
  2. 2.Defence Medical and Environmental Research InstituteNational Cancer CentreSingapore

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