Abstract
Micro-FT-IR spectroscopy was used to study breast cancer tissues and, in particular osteosarcoma tissue. By analysing the spectra, we have found characteristic bands in the infrared regions, where the main components of these signature bands are located. In the region between 1680-1660 cm-1 are found the characteristic bands of Amide I and II of proteins. The bands, which correspond to the vibrations of the phosphate groups, are found in the region near 1140-900 cm-1. These characteristic bands have been monitored as a function of the degree of cancer progression. The results have been obtained with chemometric methods, such as cluster analysis, principal component analysis and custom analysis in order to distinguish the neoplastic zones from the normal zones.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
REFERENCES
B. Chance et al, Breast cancer detection based on incremental biochemical and physiological properties of breast cancers. Acad. Radiol., 12 (2005) 925–933.
Breast MRI Web Site.
M. Petra, J. Anastassopoulou, T. Theologis, T. Theophanides, Synchrotron micro-FTIR spectroscopic evaluation of normal paediatric human bone, J. Mol. Str., 733 (2005) 101–110, and references therein.
L.G. Carr, Resolution limits for infrared micro-spectroscopy explored with synchrotron radiation. Rev. Sci. Instrum. 72 (2001) 1.
B. Schrader, Ed., Infrared and Raman Spectroscopy, Weinheim, VCH Verlagsgesellschaft mbH, 1995.
T. Theophanides and J. Anastassopoulou, Spectroscopy-Symmetry, National Technical University of Athens Press, Athens, 1998.
R. Eckel, et al, Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue, Vibrat. Spectr. 27 (2001) 165–173.
M. Meurens, J. Wallon, J. Tong, H. Noël and J. Haot, Breast Cancer Detection by Fourier Transform Infrared Spectrometry, Vibrat. Spect. 10 (1996) 341–346.
T Theophanides, Fourier Transform Infrared Spectroscopy, D. Reidel Publishing Co. Dodrecht, 1984.
J Anastassopoulou and T Theophanides, Raman studies of model vesicle systems, J. Appl. Spectrosc. 44 (1990) 523–524.
T. Theophanides, in: Infrared and Raman Spectroscopy Applied to Biological Molecules, (ed. T. Theophanides), D. Reidel Publishing Co, Dodrecht, Holland, p. 185 (1979).
T. Theophanides, in: Proceedings of 6th International Conference on Raman Spectroscopy in Biochemistry Section, (Eds. E.D. Schmid et al), Heyden, London, Vo 1, p. 115 (1978).
M. Jackson, L.-P. Choo, P.H. Watson, W.C. Halliday, H.H. Mantch, Beware of connective tissue proteins: assignment and implications of collagen, Bioph. Biocim. Acta, 1270 (1995) 1–6.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this paper
Cite this paper
Anastassopoulou, J. et al. (2007). MICRO-FT-IR SPECTROSCOPIC STUDIES OF BREAST TISSUES. In: Tsakanov, V., Wiedemann, H. (eds) Brilliant Light in Life and Material Sciences. NATO Security through Science Series. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5724-3_25
Download citation
DOI: https://doi.org/10.1007/978-1-4020-5724-3_25
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-5722-9
Online ISBN: 978-1-4020-5724-3
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)