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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity pp 39–57Cite as

Roles of Extracellular Heat Shock Proteins: A New Sense of Danger

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Part of the book series: Heat Shock Proteins ((HESP,volume 1))

Abstract

The Heat shock proteins (HSP) were considered for many years to be intracellular proteins that were upregulated in response to physiological stress. Intracellular HSP have many important functions: as protein-folding machines, or chaperones; the protection of cells in response to stress; and the protection of cells against apoptosis. HSP have since been found to be present outside of the cell, and much research also now focuses on the importance of extracellular HSP and their effects on immune responses. This review will explore the potential roles of extracellular HSP and their significance in disease processes.

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Authors and Affiliations

  1. Chester Centre for Stress Research, Department of Biological Sciences, University of Chester, Chester

    John H.H. Williams & Claire Hunter-Lavin

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  1. John H.H. Williams
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  2. Claire Hunter-Lavin
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  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology Scott & White Memorial Hospital and Clinic and The Texas A&M University System Health Science Center College of Medicine Temple, TX, U.S.A

    Alexzander A. A. Asea

  2. Department of Surgery, School of Medicine, University of California, San Diego, CA, U.S.A

    Antonio De Maio

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Williams, J.H., Hunter-Lavin, C. (2007). Roles of Extracellular Heat Shock Proteins: A New Sense of Danger. In: Asea, A.A., Maio, A.D. (eds) Heat Shock Proteins: Potent Mediators of Inflammation and Immunity. Heat Shock Proteins, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5585-0_4

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