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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity pp 189–211Cite as

Hsp70 Family Members, Danger Signals and Autoimmunity

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Part of the book series: Heat Shock Proteins ((HESP,volume 1))

Abstract

The 70 kiloDalton family of heat shock proteins (Hsp70) are known to stimulate immune responses and have been increasingly implicated in autoimmune conditions. Hsp70 proteins are present in pathogens as well as in healthy cells. They can be expressed constitutively or elevated in response to heat or other cellular stress. Immune responses stimulated by Hsp70 family members include triggering of innate inflammatory responses, enhancing antigen presentation to self-reactive T cells, and cross priming of chaperoned tumor and other self antigens. In this chapter, we present an overview of immunomodulatory activities described for Hsp70 proteins and review the evidence implicating Hsp70 activity in autoimmunity. The ability of Hsp70 to stimulate anti-self tumor immunity and the prospect of using Hsp70 in vaccines or as adjuvants for cancer immunotherapy will be examined. Finally we discuss potential mechanisms by which Hsp70 proteins act as danger signals and regulatory molecules to the immune system

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Authors and Affiliations

  1. University of Manchester, Faculty of Life Science, Michael Smith Building, Oxford Road, Manchester, United Kingdom, M13 9PT

    Douglas G. Millar

  2. Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, Ontario, Canada, M5G 2C1

    Pamela S. Ohashi

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  1. Douglas G. Millar
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  2. Pamela S. Ohashi
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology Scott & White Memorial Hospital and Clinic and The Texas A&M University System Health Science Center College of Medicine Temple, TX, U.S.A

    Alexzander A. A. Asea

  2. Department of Surgery, School of Medicine, University of California, San Diego, CA, U.S.A

    Antonio De Maio

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Millar, D.G., Ohashi, P.S. (2007). Hsp70 Family Members, Danger Signals and Autoimmunity. In: Asea, A.A., Maio, A.D. (eds) Heat Shock Proteins: Potent Mediators of Inflammation and Immunity. Heat Shock Proteins, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5585-0_13

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