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Molecular farming of antibodies in plants

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Book cover Improvement of Crop Plants for Industrial End Uses

Abstract

Antibodies are multi-subunit glycoproteins, produced by the vertebrate immune system. They recognize and bind to their target antigens with great affinity and specificity, which allows them to be used for many applications, including the diagnosis, prevention and treatment of human and animal disease (Anderson and Krummen 2003; Chad and Chamow 2001; Fischer and Emans 2000). It is estimated that approximately 1000 therapeutic recombinant antibodies are under development, up to one quarter of which may already be undergoing clinical trials. A large proportion of these antibodies recognize cancer antigens but others have been developed for the diagnosis and treatment of infectious diseases, acquired disorders and even transplant rejection (Gavilondo and Larrick 2000). As well as biomedical applications, antibodies can also be exploited to prevent diseases in plants (Schillberg et al. 2001), to detect and remove environmental contaminants, and for various industrial processes such as affinity purification and molecular targeting (Stoger et al. 2005b).

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Authors and Affiliations

  1. Department of Biology, University of York, Heslington, York, YO10 5DD, United Kingdom

    Richard M. Twyman

  2. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Forckenbeckstrasse 6, Aachen, 52074, Germany

    Stefan Schillberg & Rainer Fischer

Authors
  1. Richard M. Twyman
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  2. Stefan Schillberg
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  3. Rainer Fischer
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Editors and Affiliations

  1. C.R.A.-ISCI, Bologna, Italy

    P. RANALLI

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Twyman, R., Schillberg, S., Fischer, R. (2007). Molecular farming of antibodies in plants. In: RANALLI, P. (eds) Improvement of Crop Plants for Industrial End Uses. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5486-0_15

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