Abstract
Increasing interest for disposable non-instrumented bioreactors is due to the possibilities these systems offer to increase assay capacity for multi-parameter process development. A system based on disposable 50 ml shaken bioreactors is presented in this report. Up to 1000 bioreactor units were tested within a time period of one week. The experiment allowed the simultaneous analysis of 29 chemically defined medium and 20 protein hydrolysates on the growth and productivity of 3 distinct CHO cell lines. The feasibility of such a study opens clearly new perspectives in rapid and efficient cell line development.
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Stettler, M. et al. (2007). 1000 Non-instrumented Bioreactors in a Week. In: Smith, R. (eds) Cell Technology for Cell Products., vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5476-1_83
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DOI: https://doi.org/10.1007/978-1-4020-5476-1_83
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-5475-4
Online ISBN: 978-1-4020-5476-1
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