Abstract
The production of cartilage-implants includes several steps of propagation accopamied by an unwanted dedifferentiation of the cells. The aim of this work was to investigate the propagation of human chondrocytes on microcarriers in a specially designed conical bioreactor as a sub-process for the production of cartilage-carrier-constructs. This technique for increasing the number of chondrocytes without losing their characteristic phenotype and ability to produce cartilage matrix can improve the development and quality of hyaline-like cartilage implants.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Nagel-Heyer, S., Goepfert, Ch., Adamietz, P., Meenen. N.M., Petersen, J.-P., and Pörtner, R., 2005, Flow-chamber bioreactor culture for generation of three-dimensional cartilagecarrier-constructs. Bioproc. Biosyst. Eng., in press
Nagel-Heyer, S., Goepfert, Ch., Morlock, M.M., and Pörtner, R., 2005, Relationship between gross morphological and biochemical data of tissue engineered cartilage-carrier-constructs. Biotechnol. Lett. 27: 187–192
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this paper
Cite this paper
Nagel-Heyer, S., Lünse, S., Leist, C., Böer, R., Goepfert, C., Pörtne, R. (2007). From Biopsy to Cartilage-carrier-constructs by Using Microcarrier Cultures as Sub-process. In: Smith, R. (eds) Cell Technology for Cell Products., vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5476-1_60
Download citation
DOI: https://doi.org/10.1007/978-1-4020-5476-1_60
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-5475-4
Online ISBN: 978-1-4020-5476-1
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)