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Computational Fluid Dynamics Applied to Laboratory Scale Cell Culture Reactors for the Prediction of Hydrodynamic Stress

  • Eric Olmos
  • Nicolas Fischbach
  • Annie Marc
Conference paper

Abstract

Using Computational Fluid Dynamics, a method for the design of animal cell culture reactors is proposed. This approach is based on the concept of Fluid Stress Distribution and on the calculation of animal cell paths.

Keywords

Computational Fluid Dynamics Particle Image Velocimetry Animal Cell Culture Hydrodynamic Stress Roller Bottle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Haut, B., Ben Amor, H., Coulon, A., Jacquet, A., Halloin, V. 2003. Hydrodynamics and mass transfer in a Couette-Taylor bioreactor for the culture of animal cells, Chem. Eng. Sci. 58 777–784.CrossRefGoogle Scholar
  2. Morsi, S.A. and Alexander, A.J. 1972, An investigation of particle trajectories in two-phase flow systems, J. Fluid Mech. 55 193–208.CrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Eric Olmos
    • 1
  • Nicolas Fischbach
    • 1
  • Annie Marc
    • 1
  1. 1.Laboratoire des Sciences du Génie Chimique UPR CNRS 6811-INPLVandoeuvre les NancyFrance

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