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CAM-DR: HANGING ON FOR CELL SURVIVAL

  • Lori A. Hazlehurst
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Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 9)

Abstract

β1 integrin is known to be an important mediator of cell cycle kinetics, survival and differentiation. More recently evidence is accumulating that β1 integrin-mediated adhesion is sufficient to cause resistance to mechanistically distinct cytotoxics. This drug resistant phenotype is commonly referred to as cell adhesion mediated drug resistance or CAM-DR. The CAM-DR phenotype is observed in multiple tumor types that express a diverse array of oncogenes, suggesting that underlying resistant mechanism(s) do not require the expression of a specific oncogene for conferring the drug resistant phenotype. Despite the consistency of the drug resistant phenotype a single CAM-DR pathway has yet to emerge. However, current data suggest that alterations in cell cycle checkpoints and Bcl-2 family members are likely to be critical for conferring the CAM-DR phenotype. This chapter will discuss CAM-DR models and potential targets downstream of β1 integrin ligation that contribute to the drug resistant phenotype.

Keywords

U937 Cell Minimal Residual Disease Acquire Drug Resistance Drug Resistant Phenotype Confer Drug Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • Lori A. Hazlehurst
    • 1
  1. 1.Experimental Therapeutics Section, H. Lee Moffitt Cancer CenterTampaUSA

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