• Ronald L. Heimark
  • Nelson R. Alexander
Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 9)


Disruption of tight cell adhesion mediated by E-cadherin is an important step in carcinoma progression for cells to initiate cell migration and progress to metastasize. During prostate cacinogenesis, E-cadherin gene expression or function is downregulated through multiple mechanisms, many of which combine to silence E-cadherin expression through transcriptional regulation at the level of the E-cadherin promoter. Recent evidence indicates that concomitant with the transcriptional silencing of E-cadherin in prostate carcinomas, there is transcriptional upregulation of the mesenchymal cadherin, N-cadherin. The mechanisms of E- to N-cadherin switching in carcinomas and Key the potential roles of N-cadherin in tumor metastasis are summarized.


Prostate Cancer Fibroblast Growth Factor Receptor DU145 Cell Prostate Carcinoma Cell Cadherin Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2006

Authors and Affiliations

  • Ronald L. Heimark
    • 1
  • Nelson R. Alexander
    • 1
  1. 1.Department of Surgery and the Cancer Biology GraduateProgram, Arizona Health Sciences CenterUniversity of ArizonaTucsonUSA

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