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SUPPRESSION AND ALTERATION OF ADHESION STRUCTURES IN HUMAN EPITHELIAL CANCER PROGRESSION

  • Tracy L. Davis
  • Aaron J. Goldman
  • Anne E. Cress
Chapter
  • 505 Downloads
Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 9)

Abstract

An early step in epithelial cancer progression is the loss of cell adhesion structures and the persistence of selected sets of adhesion proteins. In this chapter, the data from immunohistochemical analysis of human tissue and published DNA microarray results from human tissue are discussed to illustrate the altered expression of cell adhesion structures in carcinomas. Further, the role of adhesion structures in cancer metastasis is discussed and the inherited alterations in adhesion molecules associated with increased risk for certain carcinomas is detailed. Finally, the potential utility of elements of the adhesion structures as surrogate and end point biomarkers is discussed.

Keywords

Squamous Cell Carcinoma Focal Adhesion Kinase Basal Cell Carcinoma Bullous Pemphigoid Epidermolysis Bullosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • Tracy L. Davis
    • 1
  • Aaron J. Goldman
    • 2
  • Anne E. Cress
    • 2
  1. 1.Department of PathologyMassachusetts General HospitalBostonUSA
  2. 2.Department of Molecular and Cellular BiologyUniversity of ArizonaTucsonUSA

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