• Elisabeth L. Bair
  • Raymond B. Nagle
Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 9)


Cellular homeostasis is achieved by cells continuously sending and receiving information, through cell-cell contacts, signals from the surrounding extracellular matrix (ECM), or from soluble hormones and growth factors. During cancer progression, these normal signals may be altered in a variety of ways forcing extracellular and intracellular changes to occur that will favor metastasis. Altering ECM ligands is a major mechanism by which transformed cells metastasize. One way in which ECM ligands change is through alterations in ECM composition. Another mechanism is through proteolysis of ECM proteins causing the release of growth factors or cryptic ECM peptides called matrikines. In this chapter, we will discuss changes that occur in ECM and examine how these changes are important for successful cancer metastasis.


Proteolytic Enzyme Extracellular Environment Epidermolysis Bullosa Curr Opin Cell Biol Semin Cancer Biol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2006

Authors and Affiliations

  • Elisabeth L. Bair
    • 1
  • Raymond B. Nagle
    • 1
  1. 1.Arizona Cancer CenterUniversity of ArizonaTucsonUSA

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