From the Atomic Age to The Genome Project

  • Monica J. Justice

The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace. The sequencing has not only disclosed many novel genes, but allows for the evolutionary comparisons of genes and their expression. The future challenge will be to discover how their regulation and functions have changed over evolutionary distance and speciation.

Mutagenesis is being carried out in many model organisms to discover new gene functions, because genetic variants have enabled the understanding of gene regulation, and biochemical and developmental pathways. The mouse is the first mammalian organism to be subjected to large-scale mutagenesis, and will permit key discoveries because of its many morphological, physiological, developmental and reproductive similarities to the human. A comparative analysis of gene functions that includes the laboratory mouse will expand our knowledge of the genetic, developmental and physiological differences between a mammal and a fruit fly.

The Second Annual Georgia Genetics Symposium: Mutagenesis of the Mouse Genome focused on new directions in functional genetics in the mouse. Our goal in this meeting was to invite speakers who were tackling the genome using a variety of mutagenesis techniques. Further, the development of resources and infrastructure for managing mutant mouse strains was needed. Therefore, we decided to build a program that focused on the generation, mapping and management of mouse mutant resources. In doing so, we hoped to demonstrate that the mouse would become one of the most powerful of model organisms to help to annotate the functions of genes in mammals.

Keywords: functional genomics; Human Genome Project; mouse genome sequence; mouse mutagenesis; specific locus test


Human Genome Project Mouse Genome Sequence Mutagenesis Technique Mutant Mouse Strain Mouse Mutagenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Monica J. Justice
    • 1
  1. 1.Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA

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