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Synthetic Vectors for Genetic Drug Delivery

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Keywords

  • Gene Delivery
  • Peptide Nucleic Acid
  • Cationic Lipid
  • Fluorescence Correlation Spectroscopy
  • Cationic Liposome

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Itani T., Ariga H., Yamaguchi N., Tadakuma T., Yasuda T. (1987) A simple and efficient liposome method for transfection of DNA into mammalian cells grown in suspension. Gene 56: 267-276.

    CAS  PubMed  Google Scholar 

  2. Kaneda Y., Uchida T., Kim J., Ishiura M., Okada Y. (1987) The improved efficient method for introducing macromolecules into cells using HVJ (Sendai virus) liposomes with gangliosides. Exp. Cell Res. 173: 56-59.

    CAS  PubMed  Google Scholar 

  3. Mannito R.T., Goulg-Fogerite S. (1988) Liposome mediated gene transfer. Biotechniques 6: 682-690.

    Google Scholar 

  4. Haga N., Yaki K. (1989) An improved method for entrappment of plasmids in liposomes. J. Clin. Biochem. Nutr. 7: 175-183.

    CAS  Google Scholar 

  5. Kato K., Nakanishi M., Kanede Y., Uchida T., Okafa Y. (1991) Expression of hepatitis B virus surface antigen in adult rat liver: co-introduction of DNA and nuclear protein by a simplified method. J. Biol. Chem 266: 3361-3364.

    CAS  PubMed  Google Scholar 

  6. Pang S.W., Park H.Y., Jang Y.S., Kim W.S., Kim J.H. (2002) Effects of charge density and particle size of poly(styrene/(dimethylamino)ethyl methacrylate) nanoparticle for gene delivery in 293 cells. Colloids and Surface B: Biointerfaces 26: 213-222.

    CAS  Google Scholar 

  7. Ito K., Asano T., Vaughan E.D. Jr, Poppas D.P., Hayakawa M., Felsen D. (2004) Liposome-mediated gene therapy in kidney. Hum. Cell 17: 17-28.

    PubMed  Google Scholar 

  8. Litzinger David C., Brown Jeffrey M., Wala I., Kaufman Stephen A., Van Gwyneth Y., Farrell Catherine L., Collins David (1996) Fate of cationic liposomes and their complex with oligonucleotide in vivo. Biochim. Biophys. Acta 1281: 139-149.

    Google Scholar 

  9. Zhao Dan-Dan, Watarai Shinobu, Lee Jin-Tae, Kouchi, Ohmori Hitishi, Yasuda Tatsuji (1997) Gene transfection by cationic liposomes: comparision of the transfection efficiency of liposomes prepared from various positively charged lipids. Acta Med. Okayama 51: 149-154.

    Google Scholar 

  10. Felgner P.L., Gadek T.R., Holm M., Roman R., Chan H.S., Wenz M., Northrop J.P., Ringold G.M., Danielsen H. (1987) Lipofection: A highly efficient, lipid-mediated DNA transfection procedure. Proc. Natl. Acad. Sci. USA 84: 7413-7417.

    CAS  PubMed  Google Scholar 

  11. Brigham K.L., Meyrick B., Berry L.C., King G. Jr (1989) Expression of prokaryotic gene in cultured lung endothelial cells after lipofection with a plasmid vector. Am. J. Respir. Cell. Mol. Biol. 1: 95-100.

    CAS  PubMed  Google Scholar 

  12. Koshizaka T., Harashi Y., Yaki K. (1989) Novel liposomes for efficient transfection of B-galactoside gene into COS-1 cells. J. Clin. Biol. Chem. Nutr. 7: 185-192.

    CAS  Google Scholar 

  13. Felgner P.L. (1990) Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides. Adv. Drug Delivery Rev. 5: 167-187.

    Google Scholar 

  14. Muller S.R., Sullivan Pd., Clegg D.O., Feinstein S.C. (1990) Efficient transfection and expression of heterologous gene in PCI 2 cells. DNA Cell. Biol. 9: 221-229.

    CAS  PubMed  Google Scholar 

  15. Gao X., Huang L. (1991) A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem. Biophys. Res. Commun. 179: 280-285.

    CAS  PubMed  Google Scholar 

  16. Yagi K., Noda H., Kurono M., Ohishi N. (1993) Efficient gene transfer with less cytotoxicity by means of cationic multilamellar liposomes. Biochem. Biophys. Res. Commun. 196: 1042-1048.

    CAS  PubMed  Google Scholar 

  17. Wolff J.A., Malone R.W., Williams P., Chong W., Ascadi G., Jani A., Felgner P.L. (1990) Direct gene transfer into mouse muscle in vivo. Science 247: 1465-1468.

    CAS  PubMed  Google Scholar 

  18. Rose J.k., Buonocore L., Whitt M.A. (1991) A new cationic liposome reagent mediating nearly quantitative transfection of animal cells. Biotechniques 10: 520-525.

    CAS  PubMed  Google Scholar 

  19. Litzinger D.C., Huang L. (1992) Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications. Biochim. Biophys. Acta 1113: 201-227.

    CAS  PubMed  Google Scholar 

  20. Stribling R., Beunett E., Liggitt D., Gaensler K., Debs R. (1992) Aerosol gene delivery in vivo. Proc. Natl. Acad. Sci USA 89: 11277-11281.

    CAS  PubMed  Google Scholar 

  21. Zhu N., Liggitt D., Liu Y., Debs R. (1993) Systemic gene expression after intravenous DNA delivery into adult mice. Science 261: 209-211.

    CAS  PubMed  Google Scholar 

  22. Ohilip R., Liggitt D., Philip M., Dazin P., Debs R. (1993) In vivo gene delivery: efficient transfection of T lymphocytes in adult mice. J. Biol. Chem. 268: 16087-16090.

    Google Scholar 

  23. Plautz G.E., Wu B., Gao X., Huang L., Nabel G.T. (1993) Immunotherapy of malignancy by in vivo gene transfer into tumours. Proc. Natl. Acad. Sci USA 90: 4645-4649.

    CAS  PubMed  Google Scholar 

  24. Trivedi R.A., Dickson D. (1995) Liposome-mediated gene transfer into normal and dystrophin-deficient mouse myoblasts. J. Neurochem. 64: 2230-2238.

    CAS  PubMed  CrossRef  Google Scholar 

  25. Hofland H., Huang L. (1995) Inhibition of human ovarian carcinoma cell proliferation by liposome-plasmid DNA complex. Biochem. Biophys. Res Commun. 207: 492-496.

    CAS  PubMed  Google Scholar 

  26. Kojima H., Ohishi N., Takamori M., Yagi K. (1995) Cationic multilamellar liposome- mediated gene transfer into primary myoblast. Biochim. Biophys. Res. Commun. 207: 8-12.

    CAS  Google Scholar 

  27. Meyer K.B., Thompsom M.M., Levy M.Y., Barron L.G., Szoka F.C. Jr (1995) Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics. Gene Ther. 2: 450-460.

    CAS  PubMed  Google Scholar 

  28. Gaucheron J., Boulanger C., Santaella C., Sbirrazzidi N., Boussif O., Vierling P. (2001) In vitro cationic lipid-mediated gene delivery with fluorinated glycerophosphoethanolamine helper lipids. Bioconjug. Chem. 12: 949-963.

    CAS  PubMed  Google Scholar 

  29. Rejman J., Wagenaar A., Engberts J.B., Hoekstra D. (2004) Characterization and transfection properties of lipoplexes stabilized with novel exchangeable polyethylene glycol- lipid conjugates. Biochim. Biophys. Acta 28: 41-52.

    Google Scholar 

  30. Yingyongnarangkul B.E., Howarth M., Ekkiott T., Bradley M. (2004) Solid phase synthesis of 89-polyamine-based cationic lipids for DNA delivery to mammalian cells. Chemistry 23: 463-473.

    Google Scholar 

  31. Van Zanten J., Doornbos-Van der Meer B., Audouy S., Kok R.J. de Ley L. (2004) A nonviral carrier for targeted gene delivery to tumor cells. Cancer Gene Ther 11: 156-164.

    CAS  PubMed  Google Scholar 

  32. Cornelis S., Vandenbranden M., Ruysschaert J-M., Elouahabi A., (2002) Role of intracellular cationic lipid-DNA complex dissociation in transfection mediated by cationic lipids. DNA and Cell Biology 21: 91-97.

    CAS  PubMed  Google Scholar 

  33. Karmali P.P., Kumar V.V., Chaudhuri A. (2004) Design, synthesis and in vitro gene delivery efficacies of novel mono-, di- and trilysinated cationic lipids, a structure-activity investigation. J. Med. Chem. 47: 2123-2132.

    CAS  PubMed  Google Scholar 

  34. Montier T., Delepine P., Benvegnu T., Ferrieres V., Miraman M.L., Dagorn S., Guillaume C., Plusquellec D., Ferec C. (2004) Efficient gene transfer into human epithelial cell lines using glycosylated cationic carriers and neutral glycosylated co-lipids. Blood Cell Mol. Dis. 32: 271-282.

    CAS  Google Scholar 

  35. Lesage D., Cao A., Briane D., Lievre N., Coudert R., Raphael M., Salzmann J.L., Taillandier E. (2002) Evaluation and optimization of DNA delivery into gliosarcoma 9L cells by a cholesterol-based cationic liposome. Biochim. Biophys. Acta 1564: 393-402.

    CAS  PubMed  Google Scholar 

  36. Schatzlein A.G. (2001) Non-viral vectors in cancer gene therapy:principles and progress. Anticancer Drugs 12: 275-304.

    CAS  PubMed  Google Scholar 

  37. Gregoriadis G. (1999) DNA vaccines: a role for liposomes. Curr. Opin. Mol. Ther. 1: 39-42.

    CAS  PubMed  Google Scholar 

  38. Gaucheron J., Santaella C., Vierling P. (2002) Transfection with fluorinated lipoplexes based on fluorinated analogues of DOTMA, DMRIE and DPPES. Biochim. Biophys. Acta 1564: 349-358.

    CAS  PubMed  Google Scholar 

  39. Felgner P.L., Barenholz Y., Behr J.P., Cheng S.H., Cullis P., Huang L., Jessee J.A., Seymour L., Szoka F., Thierry A.R., Wagner E., Wu G. (1997) Nomenclature for synthetic gene delivery systems. Hum. Gene Ther. 8: 511-512.

    CAS  PubMed  Google Scholar 

  40. Verderone G., Van Craynest N., Boussif O., Santaella C., Bischoff R., Kolbe H.V.J., Vierling P. (2000) Lipopolycationic telomers for gene transfer: synthesis and evaluation of their in vitro transfection efficiency. J. Med. Chem. 43: 1367-1379.

    CAS  PubMed  Google Scholar 

  41. Fahr A., Muller K., Nahde T.H., Muller R., Brusselbach S. (2002) A new collidal lipidic system for gene therapy. J. Liposome research 12: 37-44.

    CAS  Google Scholar 

  42. Erni C., Suard C., Freitas S., Dreher D., Merkle H.P., Walter E. (2002) Evaluation of cationic solid lipid microparticles as synthetic carriers for the targeted delivery of macromolecules to phagocytic antigen-presenting cells. Biomaterials 23: 4667-4676.

    CAS  PubMed  Google Scholar 

  43. Mislick K.A., Baldechwieler D. (1996) Evidence fort he role of proteoglycans in cation- mediated gene transfer. Proc. Natl. Acad.Sci. USA 93: 12349-12354.

    CAS  PubMed  Google Scholar 

  44. Mounkes L.C., Zhong W., Cipres-Palaci G., Heath T.D., Debs R.J. (1998) Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J. Biol. Chem. 273: 26164-26170.

    CAS  PubMed  Google Scholar 

  45. Ruponen M., Yla-Herttuala S., Urtti A. (1999) Interaction of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. Biochim. Biophys. Acta 1415: 331-341.

    CAS  PubMed  Google Scholar 

  46. Ruponen M., Ronkko S., Honkakoski P., Tammi M., Urtti A. (2001) Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes. J. Biol. Chem 276: 33875-33880.

    CAS  PubMed  Google Scholar 

  47. Belting M., Petersson P. (1999) Intacellular accumulation of secreted proteoglycans inhibits cationic lipid-madiated gene transfer. Co-transfer of glycosaminoglycans to the nucleus J. Biol. Chem. 274: 19375-19382.

    CAS  Google Scholar 

  48. Langner M. (2000) The intracellular fate of non-viral DNA carriers. Cell. Mol. Biol. Lett. 5: 295-313.

    CAS  Google Scholar 

  49. Straubinger R.M., Duzgunes N., Papahadjopoulos D. (1984) pH-sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules. FEBS Lett. 179: 148-154.

    Google Scholar 

  50. Tachinaba R., Futaki S., Harashima H., Kiwada H. (2003) pH-sensitive Liposomes in nuclear targeting of macromolecules. Methods In Enzymology 372: 349-361.

    Google Scholar 

  51. Oudrhiri N., Vigneron J.-P., Peuchmaur M., Lecrerc T., Lehn J.-M., Lehn P. (1997) Gene transfer by guanidinium-cholesterol cationic lipids into airway epithelial cells in vitro and in vivo. Proc. Natl. Acad. Sci USA 94: 1651-1656.

    CAS  PubMed  Google Scholar 

  52. Zuhorn I.S., Kalicharans R., Hoekstra D. (2002) Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis. J. Biol. Chem. 277: 18021-18028.

    CAS  PubMed  Google Scholar 

  53. El Ouahabi A., Thiry M., Pector V., Fuks R., Ruysschaert J.M., Vandenbranden M. (1997) The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids. FEBS Lett. 414: 187-192.

    CAS  PubMed  Google Scholar 

  54. El Ouahabi A., Thiry M., Schiffmann S., Fuks R., Nguyen-tran H., Ruysschaert J.M., Vandenbranden M. (1999) Intracellular visualization of BrdU-labeled plasmid DNA/ cationic liposome complexes. J. Histochem. Cytochem. 47: 1159-1166.

    CAS  PubMed  Google Scholar 

  55. Gaucheron J., Santaella C., Vierling P. (2001) Highly fluorinated lipospermines for gene transfer: synthesis and evaluation of their iv vitro efficiency. Bioconjug. Chem. 12: 114-128.

    CAS  PubMed  Google Scholar 

  56. Gaucheron J., Santaella C., Vierling P. (2001) Imprioved in vitro gene transfer mediated by fluorinated lipolexes in the presence of a bile salt surfactant. J. Gene Med. 3: 338-344.

    CAS  PubMed  Google Scholar 

  57. Boussif O., Gaucheron J., Boulanger C., Santaella C., Kolbe H.V.J., Vierling P. (2001) Enhanced in vitro and in vivo cationic lipid-mediated gene delivery with a fluorinated glycerophospho-ethanolamine helper lipid. J. Gene Med. 3: 109-114.

    CAS  PubMed  Google Scholar 

  58. Stuart D.D., Allen T.M. (2000) A new liposomal formulation for antisense oligodeoxynucleotides with small size, high incorporation efficiency and good stability. Biochim. Biophys. Acta 1463: 219-229.

    CAS  PubMed  Google Scholar 

  59. Bennett C.F., Chiang M., Chan H., Shoemaker J.E., Mirabelli C.K. (1992) Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 41: 1023-1033.

    CAS  PubMed  Google Scholar 

  60. Zelphati O., Szoka F.C. (1996) Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids Pharm. Res. 13: 1367-1372.

    CAS  PubMed  Google Scholar 

  61. Sun X., Zhang Z. (2004) Optimizing the novel formulation of liposome-polycation-DNA complex (LDP) by central composite design. Arch. Pharm. Res. 27: 797-805.

    CAS  PubMed  Google Scholar 

  62. Vile R.G., Sunassee K., Diaz R.M., (1998) Strategies for achieving multiple layers of selectivity in gene therapy. Molecular Medicine Today 4: 84-92.

    CAS  PubMed  Google Scholar 

  63. Fisher D., Bieber T., Li Y., Elsasser H.-P., Kissel T.A. (1999) A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine:effect of molecular weight on transfection efficiency and cytotoxicity. Pharmaceutical research 16: 1273-1279.

    Google Scholar 

  64. Sternberg B., Sorgi F.L., Huang L. (1994) New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett. 356: 361-366.

    CAS  PubMed  Google Scholar 

  65. Chander R., Schreier H. (1992) Artificial envelopes containing recombinant human immunodeficiency virus (HIV) gp160. Life Sci. 50: 481-489.

    CAS  PubMed  Google Scholar 

  66. Nahde T., Muller K., Fahr A., Muller R., Brusselbach S. (2001) Combined transductional and transcriptional targeting of melanoma cells by artificial virus-like particles. J. Gen. Med. 3: 353-361.

    CAS  Google Scholar 

  67. Pasqualini R., Koivunen E. (1997) Ruoslathi Symbol.av integrins as receptors for tumor targeting by circulating ligands. Nature Biotech. 15: 542-546.

    CAS  Google Scholar 

  68. Leonetti J., Machy P., Degols G., Lebleu L., Leserman (1990) Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication Proc. Natl. Acad. Sci USA 87: 2448-2451.

    CAS  PubMed  Google Scholar 

  69. Thierry A.R., Dritschilo A. (1992) Intracellular availability of unmodified phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity. Nucleic Acids Res. 20: 5691-5698.

    CAS  PubMed  Google Scholar 

  70. Ropert C., Malvy C., Couvreur P. (1993) Inhibition of the Friend retrovirus by antisense oligonucleotides encapsulated in liposomes: mechanism of action. Pharm. Res. 10: 1427-1433.

    CAS  PubMed  Google Scholar 

  71. Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. (1990) Amphipathic, poly- ethyleneglycols effectively prolong circulation time of liposomes. FEBS Lett. 268: 235-237.

    CAS  PubMed  Google Scholar 

  72. Papahadjopoulos D., Allen T.M., Gabizon A., Mayhew E., Matthay K., Huang S.K., Lee M.C., Woodle D.D., Lasic C., Redemann F.J.M. (1991) Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USA 88: 11460-11464.

    CAS  PubMed  Google Scholar 

  73. Ahmad I., Longenecker J., Samuel J., Allen T.M. (1993) Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice. Cancer Res 53: 1484-1488.

    CAS  PubMed  Google Scholar 

  74. Mayhew E., Allen T.M., Newmwn M.S., Woodle M.C., Vaage J., Uster P.S. (1995) Pharmacokinetics and antitumor activity of vincristine encapsulated in sterically stabilized liposomes. Int. J. Cancer 62: 199-204.

    PubMed  Google Scholar 

  75. Lopez de Menezes D.E., Pilarski L.M., Allen T.M., (1998) In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma. Cancer Res. 58: 3320-3330.

    Google Scholar 

  76. Reimer D.L., Zhang Y.P., Kong S., Wheeler J.J., Graham R.W., Bally M.B. (1995) Formation of novel hydrophobic complexes between cationic lipids and plasmid DNA. Biochemistry 34: 12877-12883.

    CAS  PubMed  Google Scholar 

  77. Wong F.M.P., Reimer D.L., Bally M.B. (1996) Cationic lipid binding to DNA: characterization of complex formation. Biochemistry 35: 5756-5763.

    CAS  PubMed  Google Scholar 

  78. Gursel I., Gursel M., Ishii K.J., Klinman D.M. (2001) Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. Journal Immunol. 167: 3324-3328.

    CAS  Google Scholar 

  79. Gregoriadis G. (1998) Genetic vaccines: strategies for optimalization. Pharmacol Res. 15: 661.

    CAS  Google Scholar 

  80. Whitmore M., Huans L.S., (1999) LPD lipopolylex initiates a potent cytokine response and inhibit tumor growth. Gene Ther 6: 1867.

    CAS  PubMed  Google Scholar 

  81. Meyer O., Kirpotin D., Hong K., Sternberg B., Park J.W., Woodle M.C., Papahadjopoulos D. (1998) Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides. J. Biol. Chem. 273: 15621.

    CAS  PubMed  Google Scholar 

  82. Lasic D.D., Papahadjopoulos D. (1995) Liposomes revisited. Science 267: 1275.

    CAS  PubMed  Google Scholar 

  83. Hong K., Zheng W., Baker A., Papahadjopoulos D. (1997) Stabilization of cationic liposome-plasmid DNA complexes by poliamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery. FEBS Lett. 400: 233.

    CAS  PubMed  Google Scholar 

  84. Mizuno M., Ryuke Y., Yoshida J. (2002) Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma model. Cancer Gene Ther. 9: 825-829.

    CAS  PubMed  Google Scholar 

  85. Hwang S.H., Hayashi K., Takayama K., Maitani Y. (2002) Liver-targeted gene transfer into a human hepatoblastoma cell line and in vivo by sterylglucoside-containing cationic liposomes. Gene Ther. 8: 1276-1280.

    Google Scholar 

  86. Heikkila A., Hiltunen M.O., Turunen M.P., Keski-Nisula L., Turunen A.M., Rasanen H., Rissanen T.T., Kosma V.M., Kosma V.M., Manninen H., Heinonen S., Yla-Herttuala S. (2001) Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/plyethyleneimine complexes. Gene Ther. 8: 784-788.

    CAS  PubMed  Google Scholar 

  87. Murray K.D., Etheridge C.J., Shah S.I., Matthews D.A., Russell W., Gurling H.M., Miller A.D. (2001) Enhanced cationic liposome-mediated transfection using the DNAbinding peptide mu(mu) from the adenovirus core. Gene Ther. 8: 453-460.

    CAS  PubMed  Google Scholar 

  88. Guillem V.M., Tormo M., Moret I., Benet I., Garcia-Conde J., Crespo A., Alino S.F. (2002) Targeted oligonucleotide delivery in human lymphoma cell lines using a polyethyleneimine based immunolipolexes. J. Control Release 83: 133-146.

    CAS  PubMed  Google Scholar 

  89. Guillem V.M., Tormo M., Revert F., Benet I., Garcia-Conde J., Crespo A., Alino S.F. (2002) Polyethyleneimine- based immunopolyplex for targeted gene transfer in human lymphoma cell lines. J. Gene Med. 4: 170-182.

    PubMed  Google Scholar 

  90. Smisterowa J., Wagenaar A., Stuart M.C.A., Polushkin E., ten Brinke G., Hulst R., Engberts J.B.F.N., Hoekstra D. (2001) Molecular shape of the cationic lipid controls the structure of cationic lipid/dioleylphosphatidylethanolamine- DNA complexes and the efficiency of gene delivery. J. Biol. Chem. 276: 47615-47622.

    Google Scholar 

  91. Pardridge W.M. (2003) Gene targeting in vivo with pegylated immunoliposomes, Methods in Enzymology 373: 507-528.

    CAS  PubMed  Google Scholar 

  92. Shi N., Pardridge W. M. (2000) Noninvasive gene targeting to the brain, Proc. Natl Acad. Sci. USA 97: 7567-7572.

    CAS  PubMed  Google Scholar 

  93. Shi N., Boado R.J., Pardridge W.M., (2001) Receptor-mediated gene targeting to tissue in vivo following intravenous administration of pegylated immunoliposomes, Pharm Res. 18: 1091-1095.

    CAS  PubMed  Google Scholar 

  94. Shi N., Zhang C., Zhu C., Boado R.J., Pardridge W.M. (2001) Brain-specific expression of an exogenous gene after in vivo administration Proc. Natl. Acad. Sci. USA 98: 12754-12759.

    CAS  Google Scholar 

  95. Tae Woo Kim, Hesson Chung, Ick Chan Kwon, Ha Chin Sung, Seo Young Jeong. (2001) Optimization of lipid composition in cationic emulsion as in vitro and in vivo transfection agents. Pharm. Res. 18:54-60.

    CAS  PubMed  Google Scholar 

  96. Teixeira H., Dubernet C., Rosilio V., Laigle A., Deverre J.R., Scherman D., Benita S., Couvreur P. (2001) Factors influencing the oligonucleotides release from O-W submicron cationic emulsion. J. Control. Release 70: 243-255.

    CAS  PubMed  Google Scholar 

  97. Klang S., Frucht-Pery J., Hoffman A., Benita S. (1994) Physicochemical characterization and acute toxicity evaluation of a positively-charged submicron emulsion vehicle. J. Pharm. Pharmacol. 46: 986-993.

    CAS  PubMed  Google Scholar 

  98. Teixeira H., Dubernet C., Chacun H., Rabinovich L., Boulet V., Deverre J.R., Benita S., Couvreur P. (2003) Cationic emulsion improves the delivery of oligonucleotides to leukemic P388/ADR cells in ascite. J Control release. 20: 473-482.

    Google Scholar 

  99. Ravi Kumar M.N., Bakowsky U., Lehr C.M. (2004) Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials 25: 1771-1777.

    CAS  PubMed  Google Scholar 

  100. Langner M. (2000) Effect of liposomal composition on its ability to carry drug. Pol. J. Pharmacol. 52: 3-14.

    CAS  PubMed  Google Scholar 

  101. Natsume A., Mizuno M., Ryuke Y., Yoshida J. (1999) Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse. Gene Ther. 6: 1626-1633.

    CAS  PubMed  Google Scholar 

  102. Yagi K., Ohishi N., Hamada A., Shamoto M., Ohbayashi M., Ishida N., Nagata A., Kanazawa S., Nishikimi M. (1999) Basic study on gene therapy of human malignant glioma by use of the cationic multilamellar liposome-entrapped human interferon beta gene. Hum. Gene Ther. 10: 1975-1982.

    CAS  PubMed  Google Scholar 

  103. Egilmez N.K., Iwanuma Y., Bankert R.B., (1996) Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer. Biochim. Biophys. Res. Commun. 221: 169-173.

    CAS  Google Scholar 

  104. Pang K.Y., Miller K.W. (1978) Cholesterol modulates the effects of membrane perturbes in phospholipids vesicles and biomembranes. Biochim. Biophys. Acta 511: 1-9.

    CAS  PubMed  Google Scholar 

  105. Cao A., Briane D., Courdert R., Vassy J., Lievre N., Olsman E., Tamboise E., Salzmann J.L., Rigaut J.-P., Tailliandier E. (2000) Delivery and pathway in MCFt cells of DNA vectorized by cationic liposomes derived from cholesterol. Acid. Drug Dev. 10: 369-380.

    CAS  Google Scholar 

  106. Zabner J., Fasbender A.J., Moninger T., Poellinger K.A., Welsh M.J. (1995) Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. 270: 18997-19007.

    CAS  PubMed  Google Scholar 

  107. Yang Q., Guo Y., Li L., Hui S.W. (1997) Effect of lipid headgroup and packing stress on poly(ethylene glycol) induced phospholipids vesicle aggregation and fusion. Biophys J. 73: 277-282.

    CAS  PubMed  Google Scholar 

  108. Zauner W., Brunner S., Buschle M., Ogris M., Wagner E. (1999) Differential behaviour of lipid based and polycation based gene transfer systems in transfecting primary human fibroblast: a potential role of polylysine in nuclear transport. Biochim. Biophys. Acta 1428: 57-67.

    CAS  PubMed  Google Scholar 

  109. Chaszczewska-Markowska M., Ugorski M., Langner M. (2004) Plazmid condensation induced by cationic compounds: hydrophilic polylysine and amphiphilic cationic lipid. Cell. Mol. Biol. Lett. 9: 3-13.

    CAS  PubMed  Google Scholar 

  110. Zobel H.-P., Werner D., Gilbert M., Noe C.R., Stieneker F., Kreuter J., Zimmer A. (1999) Effect of ultrasonication on the stability of oligonucleotides adsorbed on nanoparticles and liposomes. J. Microencapsulation 16: 501-509.

    CAS  PubMed  Google Scholar 

  111. Bertling W.M., Gareis M., Paspaleeva V., Zimmer A., Kreuter J., Nurnberg E., Harrer P. (1991) Use of liposomes, viral capsids and nanoparticles as DNA carriers. J. Biotechnol. Appl. Biochem. 13: 390-405.

    CAS  Google Scholar 

  112. Cherng J.Y., Van De Wetering P., Talsma H., Crommelin D.J., Hennink W.E. (1996) Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res. 13: 1038-1042.

    CAS  PubMed  Google Scholar 

  113. Wasan E.K., Reimer D.L., Bally M.B. (1996) Plasmid DANN is protected against ultrasonic cavitation-induced damage when complexed to cationic liposomes. J. Pharm. Sci 85: 427-433.

    CAS  PubMed  Google Scholar 

  114. Solodin I., Brown C.S., Bruno M.S., Chow C.Y., Jang E.H., Debs R.J., Heath T.D. (1995) A novel series of amphiphilic imidazolinium compounds for in vitro gene delivery. Biochemistry 34: 13537-13544.

    CAS  PubMed  Google Scholar 

  115. Kondo T., Arai S., Kuwabara M., Yoshi G., Kano E. (1985) Damage in DNA irradiated with 1.2 MHZ ultrasound and its effect on template activity of DNA for RNA synthesis. Radiation Research 104: 284-292.

    CAS  PubMed  Google Scholar 

  116. Munshi C.B., Graeff R., Lee H.C. (2002) Evidence for a causal role of CD38 expression in granulocytic differentiation of human HL-60 cells. J. Biol. Chem. 277: 49453-49458.

    CAS  PubMed  Google Scholar 

  117. Junghans M., Kreuter J., Zimmer A. (2000) Antisense delivery using protamine- oligonucleotide particle. Nucleic Acids Res. 28: 45.

    Google Scholar 

  118. Zimmer A., Atmaca-Abdel Aziz S., Gilbert M., Werner D., Noe C.R. Synthesis of cholesterol modified cationic lipids for liposomal drug delivery of antisense oligonucleotides. Eur. J. Pharm. Biopharm 47: 175-178.

    Google Scholar 

  119. Sorgi F.L., Bhattacharaya S., Huang L. (1997) Protamine sulfate enhances lipid- mediated gene transfer. Gene Ther. 4: 961-968.

    CAS  PubMed  Google Scholar 

  120. Fattal E., Delattre J., Dubernet C., Couvreur P. (1999) Liposomes for delivery of nucleotides and oligonucleotides. S.T.P. Pharma Science 9: 383-390.

    CAS  Google Scholar 

  121. White J., Kielian M., Helenius A. (1983) Membrane fusion proteins of enveloped animal viruses. Quart. Rev. Biophys. 16: 151-195.

    CAS  Google Scholar 

  122. Sudimack Jennifer J., Guo Wenjin, Tjarks Werner, Lee Robert J. (2002) A novel pH-sensitive liposome formulation containing oleyl alcohol. Biochim. Biophys. Acta 1564: 31-37.

    CAS  PubMed  Google Scholar 

  123. Torchilin V.P., Zhou F., Huang L. (1993) pH-sensitive liposomes. J. Liposome Res. 3: 201-255.

    CAS  Google Scholar 

  124. Duzgunes N., Straubinger R.M., Baldwin P.A., Papahadjopoulos D. (1991) in: J. Wilschut, D. Hoekstra (Eds.), Membrane fusion, Marcel Dekker, New York, pp. 713-730.

    Google Scholar 

  125. Connor J., Yatvin M.B., Huang L. (1984) pH sensitive liposomes: acid-induced liposome fusion. Proc. Natl. Acad. Sci. USA 81: 1715-1718.

    CAS  PubMed  Google Scholar 

  126. Harlos K., Eibl H. (1981) Hexagonal phase in phospholipids with saturated chains: phosphatidylethanolamine and phosphatidic acid. Biochemistry 20: 2888-2892.

    CAS  PubMed  Google Scholar 

  127. Duzgunes N., Sraubinged R.M., Baldwin P.A., Friend D.S., Papahadjopoulos D. (1985) Proton induced fusion of oleic acid-phosphatidylethanolaminr liposomes. Biochemistry 24: 3091-3098.

    CAS  PubMed  Google Scholar 

  128. Bentz J., Ellens H., Laim M.Z., Szoka jr F.C. (1985) On the correlation between HII phase and the contact induced destabilization of phosphatidylethanolamine-containing membranes. Proc. Natl. Acad. Sci. USA 82: 5742-5745.

    CAS  PubMed  Google Scholar 

  129. Liu D., Huang L. (1990) pH-sensitive, plasma-stable liposomes with relatively prolonged resistance in circulation. Biochim. Biophys. Acta 1022: 348-354.

    CAS  PubMed  Google Scholar 

  130. Ellens H., Bentz J., Szoka F.C. (1984) pH-induced destabilization of phospha- tidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry 23: 1532-1538.

    PubMed  Google Scholar 

  131. Cullis P.R., De Kruijff B. (1979) Lipid polymorphism and the functional roles of lipids in biological membranes. Biochim. Biophys. Acta 559: 399-420.

    CAS  PubMed  Google Scholar 

  132. Chu C.J., Djikstra J., Lai M.-Z., Hong K., Szoka F.C. (1990) Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cell in culture. Pharm.Res 7: 824-834.

    CAS  PubMed  Google Scholar 

  133. Lee R.J., Wang S., Turk M.J., Low P.S. (1998) The effect of pH and intraliposomal buffer strength on the rate of liposome content release and intracellular drug delivery. Biosci. Rep. 18: 69-78.

    CAS  PubMed  Google Scholar 

  134. Subbarao N.K., Parente R.A., Szoka F.C., Nadasdi L., Pongracz K. (1987) pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry 26: 2964-2972.

    CAS  PubMed  Google Scholar 

  135. Connor J., Norley N., Huang L., (1986) Biodistribution of pH-sensitive immunoliposomes Biochim.Biophys. Acta 884: 474-481.

    CAS  Google Scholar 

  136. Liu D., Huang L. (1989) Small, but not large unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid can be stabilized by human plasma. Biochemistry 28: 7700-7707.

    CAS  PubMed  Google Scholar 

  137. Collins D., Litzinger D.C., Huang L. (1990) Structural and functional comparision of pH-sensitive liposomes composed of phosphatidylrthanolamine and three different diacylsuccinylglycerols. Biochim. Biophys. Acta 884: 234-242.

    Google Scholar 

  138. Slepushkin V.A., Simoes S., Dazin P., Newman M.S., Guo L.S., Pedroso de Lima M.C., Duzgunes N. (1997) Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo. J. Biol. Chem. 272: 2382-2388.

    CAS  PubMed  Google Scholar 

  139. Hui S.W., Langner M., Zhao Y.L., Ross p., Hurley E., Chan K., (1996) The role of helper lipids in cationic liposome-mediated gene transfer. Biophys J. 72: 590-599.

    Google Scholar 

  140. http://WWW.GENETOOLS,LLC.

  141. Summerton J.E. (1999) Morpholino antisense oligomers : the case for an Rhase H-independent structural type. Biochim. Biophys. Acta 1489: 141-158.

    CAS  PubMed  Google Scholar 

  142. Morcos P.A. (1999) Gene switching: a strategy for analyzing a broad range of mutations using steric block antisense oligo. Methods in Enzymology 313: 174-189.

    Google Scholar 

  143. Lawn R.M. (1999) The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J. Clin. Invest. 8: 104.

    Google Scholar 

  144. Giles R.V., Spiller D.G., Clark R.E., Tidd D.M. (1999) Antisense morpholino oligonucleotide analog induces missplicing of C-myc mRNA. Antisense Nucleic Acid. Drug Dev. 9: 213-220.

    CAS  Google Scholar 

  145. Schmajuk G., Sierakowska H., Kole R. (1999) Antisense oligonucleotides with different backbones. Modification of splicing pathway and efficacy of uptake. J. Biol. Chem. 274: 21783-21789.

    CAS  PubMed  Google Scholar 

  146. Summerton J.E. (1997) Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic Acid Drug Dev. 7: 187-195.

    CAS  PubMed  Google Scholar 

  147. Partridge M., Vincent A., Matthews P., Puma J., Stein D., Summerton J. (1996) A simple method for delivering morpholino antisense oligos into the cytoplasm of cells. Antisense Nucleic Acid Drug Dev. 6: 169-175.

    CAS  PubMed  Google Scholar 

  148. Special Issue: Morpholino Gene Knockdowns. (2001) Genesis: 30 (3)- all 27 papers.

    Google Scholar 

  149. Draper B.W., Marcos P.A., Kimmel C.B. (2001) Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: a quantifiable method for gene knockdown. Genesis 30: 154-156.

    CAS  PubMed  Google Scholar 

  150. Heasman J. (2002) Morpholino oligos: making sense of antisense?. Dev. Biol. 243: 209-214.

    CAS  PubMed  Google Scholar 

  151. Mc Manus M.T., Sharp P.A. (2002) Gene silencing in mammals by small interfering RNAs. Nature Rev. Genet. 3: 737-747.

    CAS  Google Scholar 

  152. Dillin A. (2003) The specifics of small interfering RNA specificity. Proc. Natl. Acad. Sci USA 100: 6289-6291.

    CAS  PubMed  Google Scholar 

  153. Tuschl T. (2002) Expanding small RNA interference. Nature Biotechnol. 20: 446-448.

    CAS  Google Scholar 

  154. Dias N., Stein C.A. (2002) Antisense oligonucleotides: basic concept and mechanism. Mol. Cancer Ther. 1: 347-355.

    CAS  PubMed  Google Scholar 

  155. Dove A. (2002) Antisense and sensibility. Nat. Biotechnol. 20: 121-124.

    CAS  PubMed  Google Scholar 

  156. Opaliɶska J.B., Gewirtz A.M. (2002) Nucleic-acid therapeutics: basis principles and recent applications. Natl. Rev. Drug Discovery 1: 503-514.

    Google Scholar 

  157. Morris M.C., Chaloin L., Choob M., Archdeacon J., Heitz F., Divita G. (2004) Combination of a new generation of PNAs with a peptide-based carrier enables efficient targeting of cell cycle progression. Gene Ther. 11: 757-764.

    CAS  PubMed  Google Scholar 

  158. Sazani P., Vacek M.M., Kole R. (2002) Short-term and long-term modulation of gene expression by antisense therapeutics. Curr. Opin Biotechnol. 13: 468-472.

    CAS  PubMed  Google Scholar 

  159. Kurrech J. (2003) Antisense technologies: improvement though novel chemical modifications. Eur. J. Biochem. 270: 1628-1644.

    Google Scholar 

  160. Nielsen P.E. (1999) Peptide nucleic acids as therapeutic agents. Curr. Opin Biotechnol. 9: 353-357.

    CAS  Google Scholar 

  161. Good L., Awasthi S.K., Dryselius R., Larsson O., Nielsen P.E. (2001) Bactericidal antisense effect of peptide-PNA conjugates. Nat. Biotechnol. 19: 360-364.

    CAS  PubMed  Google Scholar 

  162. Egholm M., Buchardt O., Christensen L., Behrens C., Freier S.M., Driver D.A., Berg R.H., Kim S.K., Norden B., Nielsen P.E. (1993) PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature 365: 566-568.

    CAS  PubMed  Google Scholar 

  163. Nielsen P.E., Egholm M., Berg R.H., Buchardt O. (1991) Sequence-selective recognation of DNA by strand displacement with a thymine-substituted polyamide. Science 254: 1497-1500.

    CAS  PubMed  Google Scholar 

  164. Koppelhus U., Nielsen P.E. (2003) Cellular delivery of peptide nucleic acid. Adv. Drug Delivery Rev. 55: 267-280.

    CAS  Google Scholar 

  165. Aldrian-Herrada G., Desarmenien M.G., Orcel H., Boissin-Agasse L., Mery J., Brugidou J., Rabie A. (1998) A peptide nucleic acids (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons. Nucleic Acids Res. 26: 4910-4916.

    CAS  PubMed  Google Scholar 

  166. Braun K., Peschke P., Pipkom R., Lampel S., Wachsmuth M., Waldeck W., Friedrich E., Debus J. (2002) A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells. J. Mol. Biol. 318: 237-243.

    CAS  PubMed  Google Scholar 

  167. Pooga M., Soomets U., Hallbrink M., Valkna A., Saar K., Rezaei K., Kahl U., Hao J.X., Xu X.J., Wiesenfeld-Halin Z., Hokfelt T., Bartfai T., Langel U. (1998) Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission iv vivo. Nat. Biotechnol. 16: 857-861.

    CAS  PubMed  Google Scholar 

  168. Koppelhus U., Awasthi S.K., Zachar V., Holst H.U., Ebbsen P., Nielsen P.E. (2002) Cell-dependent differential cellular uptake of PNA, peptide, and PNA-peptide conjugates. Antisense Nucleic Acids Drug Dev. 2: 51-63.

    Google Scholar 

  169. Cutrona G., Carpaneto E.M., Ulivi M., Roncella S., Landt O., Ferrarini M., Boffa L.C. (2000) Effects in live cells of c-myc anti-gene PNA linked to a nuclear localization signal. Nat. Biotechnol. 18: 300-303.

    CAS  PubMed  Google Scholar 

  170. Branden L.J., Christensson B., C.I. (2001) In vivo nuclear delivery of oligonucleotides via hybridizing bifunctional peptide. Gene Ther. 8: 84-87.

    CAS  PubMed  Google Scholar 

  171. Sazani P., Gemignani F., Kang S.H., Maier M.A., Manoharan M., Persmark M., Bortner D., Kole R. (2002) Systematically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat. Biotechnol. 12: 1228-1233.

    Google Scholar 

  172. Tackett A., Corey D. (2002) Non-Watson - Crick interactions between PNA and DNA inhibit the ATPase activity of bacteriophage T4 Dda helicase. Nucleic Acids Res. 30: 950-957.

    CAS  PubMed  Google Scholar 

  173. Braasch D., Corey D. (2001) Synthesis, analysis, purification, and intracellular delivery of peptide nucleic acids. Methods 23: 97-107.

    CAS  PubMed  Google Scholar 

  174. Weiler J., Gausepohl H., Hauser N., Jensen O.N., Hoheisel J.D. (1997) Hybridisation based DNA screening on peptide nucleic acids (PNA) oligomer arrays. Nucleic Acids Res. 25: 2792-2799.

    CAS  PubMed  Google Scholar 

  175. Bergman F., Bannwarth W., Tam S. (1995) Solid phase synthesis of directly linked PNA-DNA hybribs. Tetrahedron Lett. 36: 6823-6826.

    Google Scholar 

  176. Efimov V.A., Chakhmakhcheva O.G., Archdeacon J., Fernandez J.M., Fedorkin O.N., Dorokhov Y.L., Atabekov J.G. (2001) Detection of 5’-cap structure of messenger RNAs with the use of the cap-jumping approach. Nucleic Acids Res. 29: 4751-4759.

    CAS  PubMed  Google Scholar 

  177. Efimov V.A., Choob M., Buryakova A., Phelan D., Chakhmakhcheva O. (2001) PNA-related oligonucleotides mimics and their evaluation for nucleic acids hybridization studies and analysis. Nucleosides Nucleotides Nucleic Acids 20: 419-428.

    CAS  PubMed  Google Scholar 

  178. Efimov V.A., Chakhmakhcheva O.G. (1999) Conjugates of polyacrylamide with oligonucleotides and their mimetics for diagnostic purpose. Bioorg Chim. 25: 848-854.

    CAS  Google Scholar 

  179. Morris M.C., Depollier J., Mery J., Heitz F., Divita G. (2001) A peptide carrier for the delivery of biologically active proteins into mammalians cells. Nat. Biotechnol. 19: 1173-1176.

    CAS  PubMed  Google Scholar 

  180. Bordi F., Cametti C. (2002) Salt-induced aggregation in cationic liposome aqueous suspension resulting in multi-step self-assembling complexes. Colloids and Surface B: Biointerfaces 26: 341-350.

    CAS  Google Scholar 

  181. Eastman S.J., Siegel C., Tousignant J., Smith A.E., Chen S.H., Sheule R.K. (1997) Biophysical characterization of cationic lipid-DNA complex. Biochim. Biophys. Acta 1325: 41-62.

    CAS  PubMed  Google Scholar 

  182. Oberle V., Bakowsky U., Zuhorn I.S., Hoekstra D. (2000) Lipoplex formation under equilibrium condition reveals a three-step biophys mechanism. Biophys J. 79: 1447-1454.

    CAS  PubMed  Google Scholar 

  183. Verwey E.J.W., Overbeck J.T.G. (1948) Theory of stability liophobic colloids. Elsevier, Amsterdam.

    Google Scholar 

  184. Overbeck J.T.G. (1948) in: H.R. Kruyt (Ed.), Colloid Science, Elsevier, Amsterdam.

    Google Scholar 

  185. Lasic D.D., (1977) Gene delivery , in: D.D. Lasic (Ed.), Liposomes in Gene Delivery, CRS Press, Boca Raton, FL, pp. 53-66.

    Google Scholar 

  186. Stamatatos L., Leventis R., Zuckermann M.J., Silvius I.R. (1988) Interactions of cationic lipid vesicles with negatively charged phospholipids vesicles and biological membranes. Biochemistry 27: 3917-3925.

    CAS  PubMed  Google Scholar 

  187. Dan N. (1998) The structure of DNA complexes with cationic liposomes-cylindrical or flat bilayers?. Biochim. Biophys. Acta 1369: 34-38.

    CAS  PubMed  Google Scholar 

  188. Dan N. (1996) Formation of ordered domains in membrane-bound DNA. Biophys. J. 71: 1267-1270.

    CAS  PubMed  Google Scholar 

  189. Gennis R.B. (1989) Biomembranes-Molecular Structure and function, Springer-Verlag, Berlin.

    Google Scholar 

  190. Israelachvili, J. (1992) Intermolecular and Surface Forces, 2nd ed. Academic press, New York.

    Google Scholar 

  191. Felgner P.L., Tsai Y.J., Sukhu L., Wheeler C.J., Manthorpe M., Marshal J., Cheng S.H. (1995) Improved cationic lipid formulation for in vivo gene therapy. Ann. NY Acad. Sci. 772: 126-139.

    CAS  PubMed  Google Scholar 

  192. Behr J.P. (1994) Gene transfer with synthetic cationic amphiphiles: prospect for gene therapy Bioconjugate Chem. 5: 382-389.

    CAS  Google Scholar 

  193. Niculescu-Duvaz D., Heyes J., Springer C.J. (2003) Structure-activity relationship in cationic lipid mediated gene transfection. Curr. Med. Chem 10:1233-1236.

    CAS  PubMed  Google Scholar 

  194. Radler J.O., Koltover I., Salditt T., Safinya C.R. (1997) Structure of DNA-cationic liposomes complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes Science 275: 810-814.

    CAS  PubMed  Google Scholar 

  195. Templeton N.S., Lasic D.D., Frederik P.M., Strey H., Roberts D.D., Pavlakis G.N. (1997) Improved DNA:liposome complexes for increased systemic delivery and gene expression Nat. Biotechnol. 15: 647-652.

    CAS  Google Scholar 

  196. May S., Ben-Shaul A. (1997) DNA-lipid complexes: stability of honeycomb-like and spaghetti-like structures. Biophys. J. 73: 2427-2440.

    CAS  PubMed  Google Scholar 

  197. Kral T., Hof M., Jurkiewicz P., Laner M. (2002) Fluorescence correlation spectroscopy (FCS) as a tool to study DNA condensation with hexadecyltrimethylammonium bromide (HTAB). Cell Mol. Biol. Lett. 7: 203-211.

    CAS  PubMed  Google Scholar 

  198. Bloomfield V.A. (1997) DNA condensation by multivalent cations. Biopolymers 44: 269-282.

    CAS  PubMed  Google Scholar 

  199. Kral T., Hof M., Langner M. (2002) The effect of spermine on plasmid condensation and dye release observed by fluorescence correlation spectroscopy. Biol. Chem. 383: 331-335.

    CAS  PubMed  Google Scholar 

  200. Jurkiewicz P., Okruszek A., Hof M., Langner M. (2003) Associating oligonucleotides with positively charged liposomes. Cell. Mol. Biol. Lett. 8: 77-84.

    CAS  PubMed  Google Scholar 

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Wyrozumska, P., Stebelska, K., Grzybek, M., Sikorski, A.F. (2006). Synthetic Vectors for Genetic Drug Delivery. In: Mozafari, M.R. (eds) Nanocarrier Technologies. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5041-1_9

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