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Nanocarrier Technologies pp 175–190Cite as

Dicationic DEGA-Based Lipid Systems for Gene Transfer and Delivery: Supramolecular Structure and Activity

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Keywords

  • Atomic Force Microscopy
  • Transfection Efficiency
  • Gemini Surfactant
  • Cationic Lipid
  • Cationic Liposome

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References

  1. Moghimi, S.M., Hunter, A.C. and Murray, J.C. (2005) Nanomedicine: current status and future prospects, The FASEB Journal, 19: 311-330.

    CrossRef  CAS  PubMed  Google Scholar 

  2. Winfree, E., Furong, L., Wenzler, L. and Seeman, N.C. (1998) Design and self-assembly of two-dimensional DNA crystals. Nature, 394: 539-544.

    CrossRef  CAS  PubMed  Google Scholar 

  3. Wong, G.C.L., Tang, J.X., Lin, A., Li, Y., Janmey, P.A. and Safinya, C.R. (2000) Hierarchical self-assembly of F-Actin cationic lipid complexes: stacked three-layer tubule networks. Science, 288: 2035-2039.

    CrossRef  CAS  PubMed  Google Scholar 

  4. Sackmann, E. and Lipowsky, R. (1995) Handbook of Biological Physics Vol. 1B (Hoff, A.J. ed.) North-Holland, Amsterdam.

    Google Scholar 

  5. Kaler, E.W., Murthy, A.K., Rodriguez, B.E. and Zasadzinski, J.A.N. (1989) Spontaneous vesicle formation in aqueous mixtures of single-tailed surfactants. Science, 245, 1371-1374.

    CrossRef  CAS  PubMed  Google Scholar 

  6. Dubois, M. and Zemb, T. (1997) Swelling limits for bilayer microstructures: the implosion of lamellar structure versus disordered lamellae. Curr. Opin. Colloid Interf. Sci. 5: 27-37.

    CrossRef  Google Scholar 

  7. Polyakova, A.A., Panchenkova, I.A., Skripnikova, M.A., and Sebyakin, Yu.L. (2003) Biol. Membr., 20 (2): 178-183.

    CAS  Google Scholar 

  8. Elkady, A.S., Tychinskii, V.P., Sebyakin, Y.L., Moskovetsev, A., Zhdanov, R. and Khokhlov, A.R. (2003) On the Structural-Gene Transfer Activity Relationship of DNA Dicationic Lipid Genosomes. Journal Biomolecular Structure and Dynamics, 20 (6): p. 898.

    Google Scholar 

  9. Elkady, A.S., Sebyakin, Y., Gallyamov, M., Moskovtsev, A., Bischoff, G., Shmyrina, A., Zhdanov, R. and Khokhlov, A. (2004) DNA-lipid supramolecular complexes: structural and functional peculiarities as studied by scanning atomic force microscopy. In: Micro-and Nanostructures of Biological Systems (G. Bischoff and H.J. Hein, eds.), 2nd edition, Shaker Verlag, Aachen, 32-48.

    Google Scholar 

  10. Zhdanov, R.I., Bogdanenko, E.V., Moskovtsev, A.A., Podobed, O.V. and Duzgunes, N. (2003) Liposomes in Gene Delivery and Gene Therapy. Methods in Enzymol. 373: 433-465.

    CrossRef  CAS  Google Scholar 

  11. Tychinsky, V.P., Kufal, G.E. and Vyshenskaja, T.V. (1997) Measurements of submicron structures with the Airyscan laser phase microscope. Quant. Electronics, 27: 735-739.

    CrossRef  Google Scholar 

  12. Tychinsky, V.P. (2001) Coherent Phase Microscopy of intracellular processes. Usp. Fiz. Nauk, 171: 649-662.

    CrossRef  Google Scholar 

  13. Filonov, A.S., Gavrilko, D.Y. and Yaminsky, I.V. (2001) FemtoScan SPM Image Processing Software Manual, Advanced Technologies Center, Moscow-66 p. (http://www.nanoscopy.net).

  14. Roland, M. (2003) D22 Manual, located at website: http://whisky.ill.fr/YellowBook/D22/D22_info/html/D22Manual.html.

  15. Aissaoui, A., Oudrhiri, N., Petit, L., Hauchecorne, M., Kan, E., Sainlos, M., Julian, S., Navarro, J., Vigneron, J.P., Lehn J.M. and Lehn, P. (2002) Progress in gene delivery by cationic lipids: guanidinium-cholesterol-based systems as an example. Current Drug Targets, 3: 1-16.

    CrossRef  CAS  PubMed  Google Scholar 

  16. Zabner, J., Fasbender, A.J., Moninger, T., Poellinger, K.A. and Welsh, M.J. (1995) Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid. J. Biol. Chem. 270: 18997-19007.

    CrossRef  CAS  PubMed  Google Scholar 

  17. Labat-Moleur, F., Steffan, A.M., Brisson, C., Perron, H., Feugeas, O., Furstenberger, P., Oberling, F., Brambilla, E. and Behr, J.P. (1996) An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther. 3: 1010-1017.

    CAS  PubMed  Google Scholar 

  18. Wrobel, I. and Collins, D. (1995) Fusion of cationic liposomes with mammalian cells occurs after endocytosis. Biochim. Biophys. Acta, 1235: 296-304.

    CrossRef  PubMed  Google Scholar 

  19. Zhou, X. and Huang, L. (1994) DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim. Biophys. Acta, 1189: 195-203.

    CrossRef  CAS  PubMed  Google Scholar 

  20. Pitard, B., Oudrhiri, N., Vigneron, J.P., Hauchecorne, M., Aguerre, O., Toury, R., Airiau, M., Ramasawmy, R., Scherman, D., Crouzeti, J., Lehn, J.M. and Lehn, P. (1999) Structural characteristics of supramolecular assemblies formed by guanidinium-cholesterol reagents for gene transfection. Proc. Nat. Acad. Sci. USA, 96: 2621-2626.

    CrossRef  CAS  PubMed  Google Scholar 

  21. Xu, Y. and Szoka, F. C. (1996) Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry, 35: 5616-5623.

    CrossRef  CAS  PubMed  Google Scholar 

  22. Lasic, D. (1997) Liposomes in Gene Delivery, CRC Press, New York.

    Google Scholar 

  23. Radler, J.O., Koltover, I., Salditt, T. and Safinya, C.R. (1997) Structure of DNA- Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes. Science, 275 (5301): 810-814.

    CrossRef  CAS  PubMed  Google Scholar 

  24. Vasilevskaya, V.V., Khokhlov, A.R., Kidoaki, S. and Yoshikawa, K. (1997) Structure of collapsed persistent macromolecules: toroid vs. spherical globule. Biopolymers. 41: 51-60.

    CrossRef  CAS  Google Scholar 

  25. Uhrikova, D., Rapp, G. and Balgavy, P. (2002) Condensed lamellar phase in ternary DNA-DLPC-cationic gemini surfactant system: a small angle synchrotron x-ray diffraction study. Bioelectrochem. 58: 87-95.

    CrossRef  CAS  Google Scholar 

  26. Elkady, A.S., Sebyakin, Y., Gallyamov, M., Moskovetsov, A., Alexeev, A., Bischoff, G., Skripnikova, M.A., Zhdanov, R. and Khokhlov, A.R. (2002) DNA Supramolecular Complexes: Structural and Functional Peculiarities as Studied by Scanning Atomic Force Microscopy. Conference paper, proceedings of the international conference on Scanning Probe Microscopy SPM-2002, Nizhny Novgorod, March 3-6, 2002, pp. 181-184.

    Google Scholar 

  27. Oberle, V., Bakowsky, U., Zuhorn, I.S. and Hoekstra, D. (2000) Lipoplex Formation under Equilibrium Conditions Reveals a Three-Step Mechanism. Biophysical Journal, 79 (3): 1447-1454.

    CrossRef  CAS  PubMed  Google Scholar 

  28. de Kruijff, B., Rietveld, A., Telders, N. and Vaandrager, B. (1985) Molecular aspects of the bilayer stabilization induced by poly (L-lysines) of varying size in cardiolipin liposomes. Biochim. Biophys. Acta, 820, 295-304.

    CrossRef  CAS  PubMed  Google Scholar 

  29. Antonietti, M., Conrad, J. and Thunemann, A. (1994) Polyelectrolyte-surfactant complexes: A new type of solid, mesomorphous material. Macromolecules, 27, 6007-6011.

    CrossRef  CAS  Google Scholar 

  30. Ponomarenko, E.A., Waddon, A.J., Bakeev, K.N., Tirrell, D.A. and MacKnight, W.J. (1996) Self-Assembled Complexes of Synthetic Polypeptides and Oppositely Charged Low Molecular Weight Surfactants. Solid-State Properties. Macromolecules, 29: 4340-4345.

    CrossRef  CAS  Google Scholar 

  31. Zschornig, O., Arnold, K., Richter, W. and Ohki, S. (1992) Dextran sulphate-dependent fusion of liposomes containing cationic stearylamine. Chem. Phys. Lipids, 63: 15-22.

    CrossRef  CAS  PubMed  Google Scholar 

  32. Radler, J.O., Koltover, I., Jamieson, A., Salditt, T., and Safinya, C.R. (1998) Structure and Interfacial Aspects of Self-Assembled Cationic Lipid-DNA Gene Carrier Complexes. Langmuir, 14, 4272-4283.

    CrossRef  Google Scholar 

  33. Roux, D. and Safinya, C.R. (1988) A synchrotron x-ray study of competing undulation and electrostatic interlayer interactions in fluid multimembrane lyotropic phases. J. Phys. (France) 49, 307.

    Google Scholar 

  34. Safinya, C.R. (1986) Phase Transitions in Soft Condensed Matter, Tormod R. and Sherrington D., Eds. (Plenum, New York, 1989), pp. 249-270. Sci. USA. 83, 7132.

    Google Scholar 

  35. Podgornik, R., Rau, D.C. and Parsegian, V.A. (1989) The action of interhelical forces on the organization of DNA double helices: Fluctuation-enhanced decay of electrostatic double layer and hydration forces. Macromolecules 22, 1780.

    CrossRef  CAS  Google Scholar 

  36. Hiemenz, PC. (1986) Principles of colloids and surface chemistry, 2nd edn. Marcer Dekker: New York.

    Google Scholar 

  37. Tang, M.X. and Szoka, F.C. (1997) The influence of polymer structure on interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Therapy, 4: 823-832.

    CrossRef  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. NRC, Egyptian Atomic Energy Authority (EAEA), 13759, Cairo, Egypt

    Ashraf S. Elkady

  2. Institute of General pathology and Pathophysiology, Russian Academy of medical Sciences, 125315, Moscow, Russian Federation

    Renat I. Zhdanov

Authors
  1. Ashraf S. Elkady
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  2. Renat I. Zhdanov
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Editor information

Editors and Affiliations

  1. Riddet Centre, Massey University, 11 222, Palmerston North, New Zealand

    M. Reza Mozafari

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© 2006 Springer

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Elkady, A.S., Zhdanov, R.I. (2006). Dicationic DEGA-Based Lipid Systems for Gene Transfer and Delivery: Supramolecular Structure and Activity. In: Mozafari, M.R. (eds) Nanocarrier Technologies. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5041-1_10

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