Analysis of p53 Gene Alterations in Cancer: A Critical View

  • Thierry Soussi

“Guardian of the genome” (Lane, 1992), “Death star” (Vousden, 2000), “Good and bad cop” (Sharpless and DePinho, 2002), “An acrobat in tumorigenesis” (Moll and Schramm, 1998), are just a few of the names that have been attributed to the p53 gene over recent years. However, the cameras (and funding) were certainly not present at the time of the discovery of p53 in 1979 (Crawford, 1983). It was only when the first alterations of the p53 gene in human cancers were discovered 10 years later, in 1989, that p53 started to become really popular, with the title of “molecule of the year” attributed by Science, in 1993 (Harris, 1993). This title was certainly justified, as the observation that more than one half of human cancers expressed a mutant p53 raised extensive clinical possibilities both for diagnosis and treatment.

Keywords

Lymphoma Arsene Electrophoresis Adduct Oligomerization 

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References

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© Springer 2007

Authors and Affiliations

  • Thierry Soussi
    • 1
  1. 1.Laboratoire de Génotoxicologie des tumeursHôpital TenonFrance

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