Gastrointestinal complications in dialysis patients

  • Joyce Gonin
  • Chagriya Kitiyakara
  • Alfonso Santos


Most nephrologists are primary health-care providers for patients receiving renal replacement therapy (1). Gastrointestinal symptoms are among the commonest complaints in this population with 79% of dialysis patients having at least one chronic gastrointestinal symptom (2). This chapter will provide an overview of gastrointestinal disorders and liver disease in end-stage renal disease (ESRD).


Peritoneal Dialysis Chronic Renal Failure Dialysis Patient Continuous Ambulatory Peritoneal Dialysis Nephrol Dial Transplant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Bender FH, Holley JL. Most nephrologists are primary care providers for chronic dialysis patients: results of a national survey. Am J Kidney Dis. 1996;28:67–71.PubMedCrossRefGoogle Scholar
  2. 2.
    Hammer J, Oesterreicher C, Hammer K, Koch U, Trindl O, Kovarik J. Chronic gastrointestinal symptoms in hemodialysis patients. Wien Klin Wochenschr. 1998;110:287–91.PubMedGoogle Scholar
  3. 3.
    Bergstrom J. Anorexia in dialysis patients. Semin Nephrol. 1996;16:222–9.PubMedGoogle Scholar
  4. 4.
    Port FK. Morbidity and mortality in dialysis patients. Kidney Int. 1994;46:1728–37.PubMedCrossRefGoogle Scholar
  5. 5.
    Abu Farsakh NA, Roweily E, Rababaa M, Butchoun R. Brief report: evaluation of the upper gastrointestinal tract in uraemic patients undergoing haemodialysis. Nephrol Dial Transplant. 1996;11:847–50.PubMedCrossRefGoogle Scholar
  6. 6.
    Arieff AI. Dialysis disequilibrium syndrome: current concepts on pathogenesis and prevention (Editorial). Kidney Int. 1994;45:629–35.PubMedCrossRefGoogle Scholar
  7. 7.
    Henrich WL. Hemodynamic instability during hemodialysis (Clinical conference). Kidney Int. 1986;30:605–12.PubMedCrossRefGoogle Scholar
  8. 8.
    Sadowski RH, Allred EN, Jabs K. Sodium modeling ameliorates intradialytic and interdialytic symptoms in young hemodialysis patients. J Am Soc Nephrol. 1993;4:1192–8.PubMedGoogle Scholar
  9. 9.
    Daugirdas JT, Ing TS. First-use reactions during hemodialysis: a definition of subtypes. Kidney Int Suppl. 1988; 24:S37–43.PubMedGoogle Scholar
  10. 10.
    Anderson JE, Yim KB, Crowell MD. Prevalence of gastroesophageal reflux disease in peritoneal dialysis and hemodialysis patients. Adv Perit Dial. 1999;15:75–8.PubMedGoogle Scholar
  11. 11.
    Kim MJ, Kwon KH, Lee SW. Gastroesophageal reflux disease in CAPD patients. Adv Perit Dial. 1998;14:98–101.PubMedGoogle Scholar
  12. 12.
    Rossner S, Burkart J, Castell DO, Dalton CB, Hylander BI. Effect of intraperitoneal fluid volume changes on esophageal pressures: studies in patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis. 1991;17:307–10.PubMedGoogle Scholar
  13. 13.
    De Vault KR, Caste11 DO. Guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Practice Parameters Committee of the American College of Gastroenterology. Arch Intern Med. 1995;155:2165–73.CrossRefGoogle Scholar
  14. 14.
    Zuckerman GR, Cornette GL, Clouse RE, Harter HR. Upper gastrointestinal bleeding in patients with chronic renal failure. Ann Intern Med. 1985;102:588.PubMedCrossRefGoogle Scholar
  15. 15.
    Margolis DM, Saylor JL, Geisse G, Deschryver-Kecskemeti K, Harter HR, Zuckerman GR. Upper gastrointestinal disease in chronic renal failure: a prospective evaluation. Arch Intern Med. 1978;138:1214.PubMedCrossRefGoogle Scholar
  16. 16.
    Franzin G, Musola R, Mencarelli R. Morphological changes of the gastroduodenal mucosa in regular dialysis uremic patients. Histopathology. 1982;6:492.Google Scholar
  17. 17.
    Militio G, Taccone-Galluci M, Brancaleone C et al. The gastroduodenal tract in uremic patients on longterm hemodialysis. Kidney Int. 1985;28(Suppl. 17):S157.Google Scholar
  18. 18.
    Wee A, Kang JY, Ho MS, Choong HL, Wu AY, Sutherland IH. Gastroduodenal mucosa in uremia: endoscopic and histological correlation and prevalence of Helicobacter-like organisms. Gut. 1990;31:1093.PubMedCrossRefGoogle Scholar
  19. 19.
    Korman MG, Laver MC, Hansky J. Hypergastrinaemia in chronic renal failure. Br Med J. 1972;1:209.PubMedCrossRefGoogle Scholar
  20. 20.
    Kang JY, Wu AY, Sutherland IH, Vathsala A. Prevalence of peptic ulcer in patients undergoing maintenance hemodialysis. Dig Dis Sci. 1988;33:774–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Tamura H, Tokushima H, Murakawa M et al. Influences of Helicobacter pylori on serum pepsinogen concentrations in dialysis patients. Nephrol Dial Transplant. 1999;14:113–17.PubMedCrossRefGoogle Scholar
  22. 22.
    Moustafa FE, Khalil A, Abdel Wahab M et al. Helicobacter pylori and uremic gastritis: a histopathologic study and a correlation with endoscopic and bacteriological findings. Am J Nephrol. 1997;17:165–71.PubMedCrossRefGoogle Scholar
  23. 23.
    Jaffe RH, Laing DR. Changes of the digestive tract in uremia; pathologic anatomic study. Arch Intern Med. 1934; 53:851.CrossRefGoogle Scholar
  24. 24.
    Vaziri ND, Dure-Smith B, Miller R, Mirahmadi MK. Pathology of gastrointestinal tract in chronic hemodialysis patients: an autopsy study of 78 cases. Am J Gastroenterol. 1985;80:608.PubMedGoogle Scholar
  25. 25.
    Chachati A, Godon JP. Effects of hemodialysis on upper gastrointestinal tract pathology in patients with chronic renal failure. Nephrol Dial Transplant. 1987;1:233.PubMedGoogle Scholar
  26. 26.
    Howden CW, Hunt RH. Guidelines for the management of Helicobacter pylori infection. Ad Hoc Committee on Practice Parameters of the American College of Gastroenterology. Am J Gastroenterol. 1998;93:2330–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Shousha S, Arnout AH, Abbas SH, Parkins RA. Antral Helicobacter pylori in patients with chronic renal disease. J Clin Pathol. 1990;43:397.PubMedCrossRefGoogle Scholar
  28. 28.
    Ali-Kaila K, Vaajalahti P, Karvonen AL, Kokki M. Gastric Helicobacter and upper gastrointestinal symptoms in chronic renal failure. Ann Med. 1991;23:403.CrossRefGoogle Scholar
  29. 29.
    Gladziwa U, Haase G, Handt S et al. Prevalence of Helicobacter pylori in patients with chronic renal failure. Nephrol Dial Transplant. 1993;8:301.PubMedGoogle Scholar
  30. 30.
    Ozgur O, Boyacioglu S, Ozdogan M, Gur G, Telatar H, Haberal M. Helicobacter pylori infection in haemodialysis patients and renal transplant recipients. Nephrol Dial Transplant. 1997;12:289–91.PubMedCrossRefGoogle Scholar
  31. 31.
    Davenport A, Shallcross TM, Crabtree JE, Davison AM, Will EJ, Heatley RV. Prevalence of Helicobacter pylori in patients with end-stage renal failure and renal transplant recipients. Nephron.1991;59:597–601.PubMedCrossRefGoogle Scholar
  32. 32.
    Antoniou S, Dimitriadis A, Kliridou M, Pavlitou K, Batzili H, Malaka E. Prevalence of Helicobacter pylori antibodies in CAPD patients. Nephron. 1997;75:358–9.PubMedCrossRefGoogle Scholar
  33. 33.
    Misra V, Misra SP, Dwivedi M et al. Decreased sensitivity of the ultrarapid urease test for diagnosing Helicobacter pylori in patients with chronic renal failure. Pathology. 1999;31: 44–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Fabrizi F, Martin P, Dixit V et al. Epidemiology of Helicobacter pylori in chronic haemodialysis patients using the new RIBA H. pylori SIA. Nephrol Dial Transplant. 1999;14:1929–33.PubMedCrossRefGoogle Scholar
  35. 35.
    Vakil N, Rhew D, Soll A, Ofman JJ. The cost-effectiveness of diagnostic testing strategies for Helicobacter pylori. Am J Gastroenterol. 2000;95:1691–8.PubMedGoogle Scholar
  36. 36.
    Vaira D, Malfertheiner P, Megraud F et al. Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study group. Lancet. 1999;354:30–3.Google Scholar
  37. 37.
    Huang JJ, Huang CJ, Ruaan MK, Chen KW, Yen TS, Sheu BS. Diagnostic efficacy of (13)C-urea breath test for Helicobacter pylori infection in hemodialysis patients. Am J Kidney Dis. 2000;36:124–9.PubMedCrossRefGoogle Scholar
  38. 38.
    Wang YL, Sheu BS, Huang JJ, Yang HB. Noninvasive stool antigen assay can effectively screen Helicobacter pylori infection and assess success of eradication therapy in hemodialysis patients. Am J Kidney Dis. 2001;38:98–103.PubMedCrossRefGoogle Scholar
  39. 39.
    Shepherd AMM, Stewart WK, Wormsley KG. Peptic ulceration in chronic renal failure. Lancet. 1973;1:1357.PubMedCrossRefGoogle Scholar
  40. 40.
    MacConell JB, Stewart WK, Thjodleifsson B, Wormsley KG. Gastric function in chronic renal failure: effects of maintenance hemodialysis. Lancet. 1975;2:1121.CrossRefGoogle Scholar
  41. 41.
    Venkatateswaran PS, Jeffers A, Hocken AG. Gastric acid secretion in chronic renal failure. Br Med J. 1972;4:22.CrossRefGoogle Scholar
  42. 42.
    Maxwell JG, Moore JG, Dixon J, Stevens LE. Gastrin levels in anephric patients. Surg Forum. 1971;127:305.Google Scholar
  43. 43.
    Falcao HA, Wesdorp IC, Fischer JE. Gastrin levels and gastric acid secretion in anephric patients and in patients with chronic and acute renal failure. J Surg Res. 1975;18:107.PubMedCrossRefGoogle Scholar
  44. 44.
    Owyang C, Miller LJ, DiMagno EP, Brennen LA, Go VW. Gastrointestinal hormone profile in renal insufficiency. Mayo Clin Proc. 1979;54:760.Google Scholar
  45. 45.
    Doherty CC, Buchannan KD, Ardill J, McGeown MG. Git hormones and renal failure. Dial Transplant. 1980;9:245.Google Scholar
  46. 46.
    Gold CH, Morley JE, Viljoen M, Tim LO, de Fomseca M, Kalk WJ. Gastric acid secretion and serum gastrin levels in patients with chronic renal failure on regular hemodialysis. Nephron. 1980;25:92.PubMedCrossRefGoogle Scholar
  47. 47.
    Muto S, Murayama N, Asano Y, Hosoda S, Miyata M. Hypergastrinemia and achlrorhydria in chronic renal failure. Nephron. 1985;40:143.PubMedCrossRefGoogle Scholar
  48. 48.
    Ghonaimy E, Barsoum R, Soliman M et al. Serum gastrin in chronic renal failure: morphological and physiological correlation. Nephron. 1985;39:86.PubMedCrossRefGoogle Scholar
  49. 49.
    Clendinnen BG, Davidson WO, Reeder DO, Jackson BM, Thomson JC. Renal uptake and excretion of gastrin in the dog. Surg Gynecol Obstet. 1971;132:1039.PubMedGoogle Scholar
  50. 50.
    Paronen I, Ala-Kaila K, Rantala I, Kainulainen H, Karvonen AL. Gastric parietal, chief, and G-cell densities in chronic renal failure. Scand J Gastroenterol. 1991;26: 696–700.PubMedCrossRefGoogle Scholar
  51. 51.
    Tokushima H, Tamura H, Murakawa M et al. Eradication of Helicobacter pylori restores elevation of serum gastrin concentrations in patients with end-stage renal disease. Intern Med. 1998;37:435–9.PubMedCrossRefGoogle Scholar
  52. 52.
    Fisher RS, Lipshutz W, Cohen S. The hormonal regulation of pyloric sphincter function. J Clin Invest. 1973;52:1289.PubMedCrossRefGoogle Scholar
  53. 53.
    Bartos V, Melichar J, Erben J. The function of the exocrine pancreas in chronic renal disease. Digestion. 1970;3:33.PubMedCrossRefGoogle Scholar
  54. 54.
    Dinoso VP Jr, Murphy SN, Saris AL et al. Gastric and pancreatic function in patients with end-stage renal disease. J Clin Gastroenterol. 1982;4:321.PubMedCrossRefGoogle Scholar
  55. 55.
    Swamy AP, Mangla JC, Ceestero VM, Guarasci G. Serum pepsinogens and gastrins in chronic hemodilaysis patients. Biochem Med. 1981;25:227.PubMedCrossRefGoogle Scholar
  56. 56.
    Salusky IB, Foley J, Nelosn P, Goodman WG. Aluminum accumulation during treatment with aluminum hydroxide and dialysis in children and young adults with chronic renal disease. N Engl J Med. 1991;324:527.PubMedCrossRefGoogle Scholar
  57. 57.
    Robertson JA, Salusky IB, Goodman WH, Norris KC, Coburn JW. Sucralfate, intestinal aluminum absorption and aluminum toxicity in a patient on dialysis. Ann Intern Med. 1989;111:179.PubMedCrossRefGoogle Scholar
  58. 58.
    Mulla H, Peek G, Upton D, Lin E, Loubani M. Plasma aluminum levels during sucralfate prophylaxis for stress ulceration in critically ill patients on continuous venovenous hemofiltration: a randomized, controlled trial. Crit Care Med. 2001;29:267–71.PubMedCrossRefGoogle Scholar
  59. 59.
    Gladwiza U, Koltz U. Pharmakokinetic optimization of treatment of peptic ulcer in patients with renal failure. Clin Pharmacokinet. 1994;27:393–408.CrossRefGoogle Scholar
  60. 60.
    Suleymanlar I, Tuncer M, Tugrul Sezer M et al. Response to triple treatment with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori infections in continuous ambulatory peritoneal dialysis patients. Adv Perit Dial. 1999;15:79–81.PubMedGoogle Scholar
  61. 61.
    Tamura H, Tokushima H, Murakawa M et al. Eradication of Helicobacter pylori in patients with end-stage renal disease under dialysis treatment. Am J Kidney Dis. 1997;29:86–90.PubMedCrossRefGoogle Scholar
  62. 62.
    Goldstein H, Murphy D, Sokol A, Rubini ME. Gastric acid secretion in patients undergoing chronic dialysis. Arch Intern Med. 1967;120:645.PubMedCrossRefGoogle Scholar
  63. 63.
    Boner G, Berry EM. Gastrointestinal hemorrhage complicating chronic hemodialysis. Isr J Med Sci. 1968;4:66.PubMedGoogle Scholar
  64. 64.
    Weiner SN, Vertes V, Shapiro H. Upper gastrointestinal tract in patients undergoing chronic dialysis. Radiology. 1969;92:110.Google Scholar
  65. 65.
    Musola R, Franzin G, Mora, Manfrini C. Prevalence of gastroduodenal lesions in uremic patients undergoing dialysis and after renal transplantation. Gastrointest Endosc. 1984;30:343.PubMedCrossRefGoogle Scholar
  66. 66.
    Kang JY. The gastrointestinal tract in uremia. Dig Dis Sci. 1993;38:257.PubMedCrossRefGoogle Scholar
  67. 67.
    Concordet D, Toutain PL. Small bowel motility and colonic transit are altered in dogs with moderate renal failure. Am J Physiol Regul Integr Comp Physiol. 2001;281:R230–8.PubMedGoogle Scholar
  68. 68.
    Raybould HE, Plourde V, Zittel T, Bover J, Quintero E. Gastric emptying of solids but not liquids is decreased in rats with chronic renal failure. Dig Dis Sci. 1994;39:2301–5.PubMedCrossRefGoogle Scholar
  69. 69.
    McNamee PT, Moore GW, McGeown MC, Doherty CC, Collins BJ. Gastric emptying in chronic renal failure. Br Med J. 1985;291:310–11.CrossRefGoogle Scholar
  70. 70.
    Kao CH, Hsu YH, Wang SJ. Delayed gastric emptying in patients with chronic renal failure. Nucl Med Commun. 1996;17:164–7.PubMedCrossRefGoogle Scholar
  71. 71.
    Wright RA, Clemente R, Wathen R. Gastric emptying in patients receiving hemodialysis. Arch Intern Med. 1984; 144:495.PubMedCrossRefGoogle Scholar
  72. 72.
    Soffer EE, Geva B, Helman C, Avni Y, Bar-Meir S. Gastric emptying in chronic renal failure patients receiving hemodialysis. J Clin Gastroenterol. 1987;9:651.PubMedCrossRefGoogle Scholar
  73. 73.
    Lin X, Mellow MH, Southmayd L, Pan J, Chen JD. Impaired gastric myoelectrical activity in patients with chronic renal failure. Dig Dis Sci. 1997;42:898–906.PubMedCrossRefGoogle Scholar
  74. 74.
    Lee SW, Song JH, Kim GA, Yang HJ, Lee KJ, Kim MJ. Effect of dialysis modalities on gastric myoelectrical activity in end-stage renal disease patients. Am J Kidney Dis. 2000;36:566–73.PubMedCrossRefGoogle Scholar
  75. 75.
    Ko CW, Chang CS, Wu MJ, Chen GH. Transient impact of hemodialysis on gastric myoelectrical activity of uremic patients. Dig Dis Sci. 1998;43:1159–64.PubMedCrossRefGoogle Scholar
  76. 76.
    Brown-Cartwright D, Smith HJ, Feldman M. Gastric emptying of an indigestible solid in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis. Gastroenterology. 1988;95:49.PubMedGoogle Scholar
  77. 77.
    Bird NJ, Streather CP, O’Doherty MJ, Barton IK, Gaunt JL, Nunan TO. Gastric emptying in patients with chronic renal failure on continuous peritoneal dialysis. Nephrol Dial Transplant. 1993;9:287–90.Google Scholar
  78. 78.
    Eisenberg B, Murata GH, Tzmaloukas AH et al. Gastroparesis in diabetics on chronic dialysis; clinical and laboratory association and predictive features. Nephron. 1995;70:296–3000.PubMedCrossRefGoogle Scholar
  79. 79.
    Ross EA, Koo LC. Improved nutrition after the detection and treatment of occult gastroparesis in nondiabetic dialysis patients. Am J Kidney Dis. 1998;31:62–6.PubMedCrossRefGoogle Scholar
  80. 80.
    Silang R, Regalado M, Cheng TH, Wesson DE. Prokinetic agents increase plasma albumin in hypoalbuminemic chronic dialysis patients with delayed gastric emptying. Am J Kidney Dis. 2001;37:287–93.PubMedCrossRefGoogle Scholar
  81. 81.
    Vita G, Bellinghieri G, Trusso A et al. Uremic autonomic neuropathy studied by spectral analysis of heart rate. Kidney Int. 1999;56:232–7.PubMedCrossRefGoogle Scholar
  82. 82.
    Sirinek KR, O’Dorisio TM, Gaskell HV, Lefine BA. Chronic renal failure hemodialysis on gastrointestinal hormone. Am J Surg. 1984;148:732.PubMedCrossRefGoogle Scholar
  83. 83.
    Hegbrant J, Thysell H, Ekman R. Plasma levels of gastrointestinal regulatory peptides in patients receiving maintenance hemodialysis. Scand J Gastroenterol. 1991;26:599.PubMedCrossRefGoogle Scholar
  84. 84.
    Doherty CC, Buchanan KD, Ardill J, McGeown MG. Elevations of gastrointestinal hormones in chronic renal failure. Proc Eur Dial Transplant Assoc. 1978;15:456–65.PubMedGoogle Scholar
  85. 85.
    Katz AI, Emmanouel DS. Metabolism of polypeptide hormones by the normal kidney and in uremia. Nephron. 1978; 22:69–80.PubMedCrossRefGoogle Scholar
  86. 86.
    Haffner J, Linnestead P, Schrumpf E, Hanssen LE, Flaten O, Oyaasaeter S. The immediate effect of human renal transplantation on basal and meal-stimulated levels of gastrointestinal hormones. Scand J Gastroenterol. 1987;22: 42–6.PubMedCrossRefGoogle Scholar
  87. 87.
    Patterson D, Abell T, Rothstein R, Koch K, Barnett J. A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. Am J Gastroenterol. 1999;94: 1230–4.PubMedGoogle Scholar
  88. 88.
    Janssens J, Peeters TL, Vantrappen G et al. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies. N Engl J Med. 1990;322:1028–31.PubMedCrossRefGoogle Scholar
  89. 89.
    Gallar P, Oilet A, Vgil A, Ortega O, Guijo G. Gastroparesis: an important cause of hospitalization in continuous ambulatory peritoneal dialysis patients and the role of erythromicin. Perit Dial Int. 1993;13(Suppl. 2):S183–6.PubMedGoogle Scholar
  90. 90.
    Wysowski DK, Corken A, Gallo-Torres H, Talarico L, Rodriguez EM. Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. Am J Gastroenterol. 2001;96:1698–703.PubMedCrossRefGoogle Scholar
  91. 91.
    Hentges MJ, Gunderson BW, Lewis MJ. Retrospective analysis of cisapride-induced QT changes in end-stage renal disease patients. Nephrol Dial Transplant. 2000;15: 1814–18.PubMedCrossRefGoogle Scholar
  92. 92.
    Simenhoff ML, Saukkonen JJ, Burke JF, Wesson LG, Schaedler RW, Gordon SJ. Bacterial populations of the small intestine in uraemia. Nephron. 1978;22:63–8.PubMedCrossRefGoogle Scholar
  93. 93.
    Arvanitakis C, Nakos V, Kalekou-Greka H, Tourkantonis A. Small intestinal function and structure in patients with chronic renal failure. Clin Nephrol. 1988;29:235–43.PubMedGoogle Scholar
  94. 94.
    Craig RM, Carlson S, Ehrenpreis ED. D-Xylose kinetics and hydrogen breath tests in functionally anephric patients using the 15-gram dose. J Clin Gastroenterol. 2000;31:55–9.PubMedCrossRefGoogle Scholar
  95. 95.
    Parfrey PS, Foley RN. The clinical epidemiology of cardiac disease in chronic renal failure. J Am Soc Nephrol. 1999;10:1606–15.PubMedGoogle Scholar
  96. 96.
    Jakob SM, Ruokonen E, Vuolteenaho O, Lampainen E, Takala J. Splanchnic perfusion during hemodialysis: evidence for marginal tissue perfusion. Crit Care Med. 2001;29:1393–8.PubMedCrossRefGoogle Scholar
  97. 97.
    Diamond SM, Emmett M, Henrich WL. Bowel infarction as a cause of death in dialysis patients. J Am Med Assoc. 1986; 256:2545.Google Scholar
  98. 98.
    Margolis DM, Etheredge EE, Garza-Garza R, Hruska K, Anderson CB. Ischemic bowel disease following bilateral nephrectomy or renal transplant. Surgery. 1977;82:667.PubMedGoogle Scholar
  99. 99.
    Dahlberg PJ, Kisken WA, Newcomer KL, Yutuc WR. Mesenteric ischemia in chronic dialysis patients. Am J Nephrol. 1985;5:327.PubMedCrossRefGoogle Scholar
  100. 100.
    John AS, Tuerff SD, Kerstein MD. Nonocclusive mesenteric infarction in hemodialysis patients. J Am Coll Surg. 2000; 190:84–8.PubMedCrossRefGoogle Scholar
  101. 101.
    Wind P, Douard R, Rouzier R, Berger A, Bony C, Cugnenc PH. Abdominal surgery in chronic hemodialysis patients. Am Surg. 1999;65:347–5.PubMedGoogle Scholar
  102. 102.
    Newman LA, Mittman N, Hunt Z, Alfonso AE. Survival among chronic renal failure patients requiring major abdominal surgery. J Am Coll Surg. 1999;188:310–14.PubMedCrossRefGoogle Scholar
  103. 103.
    Toh Y, Yano K, Takesue F et al. Abdominal surgery for patients on maintenance hemodialysis. Surg Today. 1998; 28:268–72.PubMedCrossRefGoogle Scholar
  104. 104.
    Adams PL, Rutsky EA, Rostand SG, Han SY. Lower gastrointestinal tract dysfunction in patients receiving longterm hemodialysis. Arch Intern Med. 1982;142:303.PubMedGoogle Scholar
  105. 105.
    Townsend CM Jr, Remmers AR, Sarles HE, Fish JC. Intestinal obstruction from mediation bezoar in patients with renal failure. N Engl J Med. 1973;288:1058.PubMedCrossRefGoogle Scholar
  106. 106.
    Welch JP, Schweitzer RT, Bartus SA. Management of antacid impactions in hemodialysis and renal transplant patients. Am J Surg. 1980;139:561.PubMedCrossRefGoogle Scholar
  107. 107.
    Bargman JM. Complications of peritoneal dialysis related to increased intraabdominal pressure. Kidney Int Suppl. 1993; 40:S75–80.PubMedGoogle Scholar
  108. 108.
    O’Connor JP, Rigby RJ, Hardie IR et al. Abdominal hernias complicating continuous ambulatory peritoneal dialysis. Am J Nephrol. 1986;6:271–4.PubMedCrossRefGoogle Scholar
  109. 109.
    Kanagasundaram NS, Fletcher S, Gupta S, Davison AM. Acute small-bowel obstruction following mesenteric perforation by CAPD catheter. Nephrol Dial Transplant. 1997; 12:599–600.PubMedCrossRefGoogle Scholar
  110. 110.
    Afthentopoulos JE, Passadakis P, Oreopoulos DG, Bargman J. Sclerosing peritonitis in continuous ambulatory peritoneal dialysis patients: one center’s experience and review of the literature Adv Ren Replace Ther. 1998;5: 157–67.Google Scholar
  111. 111.
    Yokota S, Kumano K, Sakai T. Prognosis for patients with sclerosing encapsulating peritonitis following CAPD. Adv Perit Dial. 1997;13:221–3.PubMedGoogle Scholar
  112. 112.
    Nomoto Y, Kawaguchi Y, Kubo H, Hirano H, Sakai S, Kurokawa K. Sclerosing encapsulating peritonitis in patients undergoing continuous ambulatory peritoneal dialysis: a report of the Japanese Sclerosing Encapsulating Peritonitis Study Group. Am J Kidney Dis. 1996;28:420–7.PubMedCrossRefGoogle Scholar
  113. 113.
    Junor BJ, McMillan MA. Immunosuppression in sclerosing peritonitis. Adv Perit Dial. 1993;9:187–9.PubMedGoogle Scholar
  114. 114.
    Johnson DW, Herzig KA, Gissane R, Campbell SB, Hawley CM, Isbel NM. A prospective crossover trial comparing intermittent intravenous and continuous oral iron supplements in peritoneal dialysis patients. Nephrol Dial Transplant. 2001;16:1879–84.PubMedCrossRefGoogle Scholar
  115. 115.
    Knobel B, Petchenko P. Hyperphosphatemic hypocalcemic coma caused by hypertonic sodium phosphate J Clin Gastroenterol. 1996;23:217–19.PubMedCrossRefGoogle Scholar
  116. 116.
    Scheff RT, Zuckermann G, Harter H, Delmez J, Koehler R. Diverticular disease in patients with chronic renal failure due to polycystic kidney disease. Ann Intern Med. 1980;92:202.PubMedCrossRefGoogle Scholar
  117. 117.
    Lederman ED, McCoy G, Conti DJ, Lee EC. Diverticulitis and polycystic kidney disease. Am Surg. 2000;66:200–3.PubMedGoogle Scholar
  118. 118.
    Abramson SJ, Berdon WE, Laffey K, Ruzal-Shapiro C, Nash M, Baer J. Colonic diverticulitis in young patients with chronic renal failure and transplantation. Pediatr Radiol. 1991;21:352–4.PubMedCrossRefGoogle Scholar
  119. 119.
    Starnes HF Jr, Lazarus JM, Vineyard G. Surgery for diverticulitis in renal failure. Dis Colon Rectum. 1985;28:827–31.PubMedCrossRefGoogle Scholar
  120. 120.
    Tranaeus A, Heimburger O, Granqvist S. Diverticular disease of the colon: a risk factor for peritonitis in continuous peritoneal dialysis. Nephrol Dial Transplant. 1990;5:141–7.PubMedCrossRefGoogle Scholar
  121. 121.
    Pirenne J, Lledo-Garcia E, Benedetti E et al. Colon perforation after renal transplantation: a single-institution review. Clin Transplant. 1997;11:88–93.PubMedGoogle Scholar
  122. 122.
    Poris JJA, Barnes AD. Ileocolonic problems after cadaver renal transplantation. Br Med J. 1972;1:99.CrossRefGoogle Scholar
  123. 123.
    Canter JW, Shore, PE. Acute perforation of colonic diverticula associated with prolonged adrenocorticosteroid therapy. Am J Surg. 1971;121:46.PubMedCrossRefGoogle Scholar
  124. 124.
    McCune TR, Nylander WA, Van Buren DH et al. Colonic screening prior to renal transplantation and its impact on post-transplant colonic complications. Clin Transplant. 1992;6:91–6.PubMedGoogle Scholar
  125. 125.
    Dominguez Fernandez E, Albrecht KH, Heemann U et al. Prevalence of diverticulosis and incidence of bowel perforation after kidney transplantation in patients with polycystic kidney disease. Transplant Int. 1998;11:28–31.CrossRefGoogle Scholar
  126. 126.
    Leung AC, Orange G, McLay A, Henderson IS. Clostridium difficile-associated colitis in uremic patients. Clin Nephrol. 1985;24:242.PubMedGoogle Scholar
  127. 127.
    D’Agata EM, Mount DB, Thayer V, Schaffner W. Hospitalacquired infections among chronic hemodialysis patients. Am J Kidney Dis. 2000;35:1083–8.PubMedCrossRefGoogle Scholar
  128. 128.
    Barany P, Stenvinkel P, Nord CE, Bergstrom J. Clostridium difficile infection — a poor prognostic sign in uremic patients? Clin Nephrol. 1992;38:53.PubMedGoogle Scholar
  129. 129.
    Krebs RA, Burtis BB. Bowel perforation. A complication of peritoneal dialysis using a permanent peritoneal cannula. J Am Med Assoc. 1966;198:486.CrossRefGoogle Scholar
  130. 130.
    Wooton FT, Rhodes DP, Lee WM, Fitts CT. Colonic necrosis with Kayexalate-sorbitol enemas after renal transplantation. Ann Intern Med. 1989;111:947.CrossRefGoogle Scholar
  131. 131.
    Roy-Chaudhury P, Meisels IS, Freedman S, Steinman TI, Steer M. Combined gastric and ileocecal toxicity (serpiginous ulcers) after oral kayexalate in sorbital therapy. Am J Kidney Dis. 1997;30:120–2.PubMedCrossRefGoogle Scholar
  132. 132.
    Lillemoe KD, Romolo JL, Hamiltin SR, Pennington LR, Burdick JF, Williams GM. Intestinal necrosis due to sodium polystyrene (Kayexalate) in sorbitol enemas: clinical and experimental support for the hypothesis. Surgery. 1987;101:267.PubMedGoogle Scholar
  133. 133.
    Mills B, Zuckerman G, Sicard G. Discrete colon ulcers as a cause of lower gastrointestinal bleeding and perforation in end-stage renal disease. Surgery. 1981;89:548.PubMedGoogle Scholar
  134. 134.
    Brown KM. Isolated ascending colon ulceration in a patient with chronic renal insufficiency. J Natl Med Assoc. 1992; 84:185.PubMedGoogle Scholar
  135. 135.
    Lipschutz DE, Easterling RE. Spontaneous perforation of the colon in chronic renal failure. Arch Intern Med. 1973; 132:758.PubMedCrossRefGoogle Scholar
  136. 136.
    Bartolomeo RS, Calabrese PR, Taubin HL. Spontaneous perforation of the colon: A potential complication of chronic renal failure. Dig Dis. 1977;22:656.CrossRefGoogle Scholar
  137. 137.
    Bischel MD, Reese T, Engel J. Spontaneous perforation of the colon in a hemodialysis patient. Am J Gastroenterol. 1980;74:182–4.PubMedGoogle Scholar
  138. 138.
    Charra B, Cuche J, Ruffet M et al. Segmental necrosis of ascending colon in haemodialysis patients. Nephrol Dial Transplant. 1995;10:2281–5.PubMedGoogle Scholar
  139. 139.
    Harwell CM, Newman LN, Cacho CP, Mulligan DC, Schulak JA, Friedlander MA. Abdominal catastrophe: visceral injury as a cause of peritonitis in patients treated by peritoneal dialysis. Perit Dial Int. 1997;17:586–94.PubMedGoogle Scholar
  140. 140.
    Tzamaloukas AH, Obermiller LE, Gibel LJ et al. Peritonitis associated with intra-abdominal pathology in continuous ambulatory peritoneal dialysis patients. Perit Dial Int. 1993; 13(Suppl. 2):S335–7.PubMedGoogle Scholar
  141. 141.
    Holley JL, Bernardini J, Piraino B. Polymicrobial peritonitis in patients on continuous peritoneal dialysis. Am J Kidney Dis. 1992;19:162–6.PubMedGoogle Scholar
  142. 142.
    Carmeci C, Muldowney W, Mazbar SA, Bloom R. Emergency laparotomy in patients on continuous ambulatory peritoneal dialysis. Am Surg. 2001;67:615–18.PubMedGoogle Scholar
  143. 143.
    Kiefer T, Schenk U, Weber J, Hubel E, Kuhlmann U. Incidence and significance of pneumoperitoneum in continuous ambulatory peritoneal dialysis. Am J Kidney Dis. 1993; 22:30–5.PubMedGoogle Scholar
  144. 144.
    Lee FT Jr, Leahy-Gross KM, Hammond TG, Wakeen MJ, Zimmerman SW. Pneumoperitoneum in peritoneal dialysis patients: significance of diagnosis by CT. J Comput Assist Tomogr. 1994;18:439–42.PubMedCrossRefGoogle Scholar
  145. 145.
    Poralla T. Angiodysplasia in the renal patient: how to diagnose and how to treat? Nephrol Dial Transplant. 1998; 13:2188–91.PubMedCrossRefGoogle Scholar
  146. 146.
    Cunningham JT. Gastric telangiectasias in chronic hemodialysis patients: a report of six cases. Gastroenterology. 1981;81:1131.PubMedGoogle Scholar
  147. 147.
    Dave PB, Romeu J, Antonelli A, Eiser AR. Gastrointestinal telangiectasias: a source of bleeding in patients receiving hemodialysis. Arch Intern Med. 1984;144:1781.PubMedCrossRefGoogle Scholar
  148. 148.
    Clouse RE, Cosatigan DJ, Mills BA, Zuckerman GR. Angiodysplasia as a cause of upper gastrointestinal bleeding. Arch Intern Med. 1985;145:458.PubMedCrossRefGoogle Scholar
  149. 149.
    Marcuard SP, Weinstock JV. Gastrointestinal angiodysplasia in renal failure. J Clin Gastroentrol. 1988;10:482.CrossRefGoogle Scholar
  150. 150.
    Navab F, Masters P, Subramani R, Ortego TJ, Thompson CH. Angiodysplasia in patients with renal insufficiency. Am J Gastroenterol. 1989;84:1297.PubMedGoogle Scholar
  151. 151.
    Gheissari A, Rajuagur V, Kumashiro R, Matsumoto T. Gastrointestinal hemorrhage in end-stage renal disease patients. Int Surg. 1990;75:93.PubMedGoogle Scholar
  152. 152.
    Chalasani N, Cotsonis MA, Wilcox CM et al. Upper gastrointestinal bleeding in patients with chronic renal failure; role of vascular ectasia. Am J Gastroenterol. 1996;91: 2329–32.PubMedGoogle Scholar
  153. 153.
    Gostout CJ, Viggiano TR, Ahlquist DA, Wang KK, Larson MV, Balm R. The clinical and endoscopi spectrum of the watermelon stomach. J Clin Gastroenterol. 1992;15: 256–63.PubMedCrossRefGoogle Scholar
  154. 154.
    Oliveras A, Aubia J, Cao H et al. 99mTc-labelled red blood cell scintigraphy for localization of gastrointestinal bleeding in chronic renal failure. Nephron. 1998;80:76–8.PubMedCrossRefGoogle Scholar
  155. 155.
    Shemin D, Elnour M, Amarantes B, Abuelo JG, Chazan JA. Oral estrogens decrease bleeding time and improve clinical bleeding in patients with renal failure. Am J Med. 1990; 89:436.PubMedCrossRefGoogle Scholar
  156. 156.
    Bonner MH, Pate MB, Cunningham JT, Marsh WH. Estrogen-progesterone therapy for bleeding gastrointestinal telangiectasias in chronic renal failure: an uncontrolled trial. Ann Intern Med. 1986;105:371.CrossRefGoogle Scholar
  157. 157.
    Richardson JD, Lordon RE. Gastrointestinal bleeding caused by angiodysplasia: a difficult problem in patients with chronic renal failure receiving hemodialysis therapy. Ann Surg. 1993;59:636.Google Scholar
  158. 158.
    Barkin JS, Ross BS. Medical therapy for chronic gastrointestinal bleeding of obscure origin. Am J Gastroenterol. 1998;93:1250–4.PubMedCrossRefGoogle Scholar
  159. 159.
    Lewis BS, Salomon P, Rivera-MacMurray S, Kornbluth AA, Wenger J, Waye JD. Does hormonal therapy have any benefit for bleeding angiodysplasia? J Clin Gastroenterol. 1992;15:99–103.PubMedCrossRefGoogle Scholar
  160. 160.
    Rossini FP, Arrigoni A, Pennazio M. Octreotide in the treatment of bleeding due to angiodysplasia of the small intestine. Am J Gastroenterol. 1993;88:1424–7.PubMedGoogle Scholar
  161. 161.
    Vujkovac B, Lavre J, Sabovic M. Successful treatment of bleeding from colonic angiodysplasias with tranexamic acid in a hemodialysis patient. Am J Kidney Dis. 1998;31:536–8.PubMedCrossRefGoogle Scholar
  162. 162.
    Campistol JM, Argiles A. Dialysis-related amyloidosis: visceral involvement and protein constituents. Nephrol Dial Transplant. 1996;11(Suppl. 3):142–5.PubMedCrossRefGoogle Scholar
  163. 163.
    Jimenez RE, Price DA, Pinkus GS et al. Development of gastrointestinal beta2-microglobulin amyloidosis correlates with time on dialysis. Am J Surg Pathol. 1998;22:729–35.PubMedCrossRefGoogle Scholar
  164. 164.
    Maher ER, Hamilton Dutoit S, Baillod RA, Sweny P, Moorhead JF. Gastrointestinal complications of dialysisrelated amyloidosis. Br Med J. 1988;297:265.CrossRefGoogle Scholar
  165. 165.
    Takahashi S, Morita, Koda Y, Murayama H, Hirasawa Y. Gastrointestinal involvement of dialysis-related amyloidosis. Clin Nephrol. 1988;30:168.PubMedGoogle Scholar
  166. 166.
    Choi HS, Heller D, Picken MM, Sidhy GS, Kahn T. Infarction of intestine with massive amyloid deposition in two patients on long-term hemodialysis. Gastroenterology. 1989;6:230.Google Scholar
  167. 167.
    Campistol JM et al. Visceral involvement of dialysis amyloidosis. Am J Nephrol. 1987;7:390–3.PubMedCrossRefGoogle Scholar
  168. 168.
    Bruno MJ, van Dorp WT, Ferwerda J, Dekker W, Schut NH. Colonic pseudo-obstruction due to beta2-microglobulin amyloidosis after long-term haemodialysis. Eur J Gastroenterol Hepatol. 1998;10:717–20.PubMedCrossRefGoogle Scholar
  169. 169.
    Kanai H, Kashiwagi M, Hirakata H et al. Chronic intestinal pseudo-obstruction due to dialysis-related amyloid deposition in the propria muscularis in a hemodialysis patient. Clin Nephrol. 2000;53:394–9.PubMedGoogle Scholar
  170. 170.
    Rosenblatt SG, Drake S, Fadem S, Welch R, Lifschitz MD. Gastrointestinal blood loss in patients with chronic renal failure. Am J Kidney Dis. 1982;1:232.PubMedGoogle Scholar
  171. 171.
    Eberst ME, Berkowitz LR. Hemostasis in renal disease: pathophysiology and management. Am J Med. 1994;96: 168–79.PubMedCrossRefGoogle Scholar
  172. 172.
    Alvarez L, Puleo J, Balian JA. Investigation of gastro-intestinal bleeding in patients with end-stage renal disease. Am J Gastroenterol. 1993;88:30.PubMedGoogle Scholar
  173. 173.
    Boyle JM, Johnston B. Acute upper gastrointestinal hemorrhage in patients with chronic renal disease. Am J Med. 1983; 75:409.PubMedCrossRefGoogle Scholar
  174. 174.
    Fiaccadori E, Maggiore U, Clima B, Melfa L, Rotelli C, Borghetti A. Incidence, risk factors, and prognosis of gastrointestinal hemorrhage complicating acute renal failure. Kidney Int. 2001;59:1510–19.PubMedCrossRefGoogle Scholar
  175. 175.
    Lau JY, Sung JJ, Lee KK et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343:310–16.PubMedCrossRefGoogle Scholar
  176. 176.
    Beck LH. Screening and preventive health practices for the end-stage renal disease patient. Adv Ren Replace Ther. 2000;7:195–201.PubMedCrossRefGoogle Scholar
  177. 177.
    Mandel JS, Bond JH, Church TR et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328:1365–71.PubMedCrossRefGoogle Scholar
  178. 178.
    Muller AD, Sonnenberg A. Prevention of colorectal cancer by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans. Ann Intern Med. 1995;123:904–10.PubMedCrossRefGoogle Scholar
  179. 179.
    Wolfe RA, Held PJ, Hulbert-Shearon TE, Agodoa LY, Port FK. A critical examination of trends in outcomes over the last decade. Am J Kidney Dis. 1998;32(Suppl. 4):S9–15.PubMedCrossRefGoogle Scholar
  180. 180.
    Maisonneuve P, Agodoa L, Gellert R et al. Cancer in patients on dialysis for end-stage renal disease: an international collaborative study. Lancet. 1999;354:93–9.PubMedCrossRefGoogle Scholar
  181. 181.
    Ajam M, Ramanujam LS, Gandhi VC et al. Colon-cancer screening in dialysis patients. Artif Organs. 1990;14:95.PubMedCrossRefGoogle Scholar
  182. 182.
    Ito T, Tanaka I, Kadoya T et al. Screening for gastroenterological malignancies in new and maintenance dialysis patients. J Gastroenterol. 1999;34:35–4.PubMedCrossRefGoogle Scholar
  183. 183.
    Akmal M, Sawelson S, Karubian F, Gadallah M. The prevalence and significance of occult blood loss in patients with predialysis advanced chronic renal failure (CRF), or receiving dialytic therapy. Clin Nephrol. 1994;42:198–202.PubMedGoogle Scholar
  184. 184.
    Lieberman DA, Rex DK. Feasibility of colonoscopy screening: discussion of issues and recommendations regarding implementation. Gastrointest Endosc. 2001;54: 662–7.PubMedCrossRefGoogle Scholar
  185. 185.
    Alter MJ, Favero MS, Moyer LA et al. National surveillance of dialysis associated diseases in the United States. Am Soc Artif Intern Organs Trans. 1990;36:107–18.CrossRefGoogle Scholar
  186. 186.
    Tokars JL, Miller ER, Alter MJ, Arduino MJ. National surveillance of dialysis associated diseases in the United States, 1995. Am Soc Artif Intern Organs Trans. 1998;36: 98–107.CrossRefGoogle Scholar
  187. 187.
    Alter MJ, Favero MS, Maynard JE. Impact of infection control strategies on the incidence of dialysis associated hepatitis in the United States. J Infect Dis. 1986;153:1149–51.PubMedCrossRefGoogle Scholar
  188. 188.
    Fabrizi F, Martin P, Lunghi G, Ponticelli C. Novel evidence on hepatitis B virus infection in dialysis. Int J Artif Organs. 2001;24:8–16.PubMedGoogle Scholar
  189. 189.
    Covic A, Lancu L, Apetrei C et al. Hepatitis virus infection in haemodialysis patients from Moldavia. Nephrol Dial Transplant. 1999;14:40–5.PubMedCrossRefGoogle Scholar
  190. 190.
    Cendoroglo Neto M, Rodrigues Manzano SI et al. Environmental transmission of hepatitis B and hepatitis C viruses within the hemodialysis unit. Int J Artif Organs. 1995;19: 251–5.CrossRefGoogle Scholar
  191. 191.
    Hung KY, Chen WY, Yang CS et al. Hepatitis B and C in hemodialysis patients. Dial Transplant. 1995;24:135–9.Google Scholar
  192. 192.
    Centers for Disease Control and Prevention. Outbreaks of hepatitis B virus infection among hemodialysis patients — California, Nebraska and Texas, 1994. J Am Med Assoc. 1996;275:1394–5.CrossRefGoogle Scholar
  193. 193.
    Tanaka S, Yoshiba M, Ino S et al. A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant. Kidney Int. 1995;48:1972–8.PubMedCrossRefGoogle Scholar
  194. 194.
    Favero MS. Guidelines for the care of patients hospitalized with viral hepatitis. Ann Intern Med. 1979;91:872–5.PubMedCrossRefGoogle Scholar
  195. 195.
    Bond WW, Favero MS, Petersen NJ et al. Survival of hepatitis B virus after drying and storage for one week. Lancet. 1981;1:550–1.PubMedCrossRefGoogle Scholar
  196. 196.
    Favero MS, Deane N, Leger RT et al. Hepatitis-B antigen on environmental surfaces (Letter). Lancet. 1973;2:1973.Google Scholar
  197. 197.
    Alter MJ, Ahtone J, Maynard JE. Hepatitis B virus transmission associated with a multiple-dose vial in a hemodialysis unit. Ann Intern Med. 1983;99:330–3.PubMedCrossRefGoogle Scholar
  198. 198.
    Vladutiu D, Cosa A, Neamtu A et al. Infection with hepatitis B and C viruses in patients on maintenance hemodialysis in Romania and in former communist countries: yellow spots on a blank map. J Viral Hepatol. 2000;7:313–19.CrossRefGoogle Scholar
  199. 199.
    Centers for Disease Control. Hepatitis Surveillance Report No. 30. Atlanta: CDC, US Dept. Health, Education and Welfare, 1969;15–20.Google Scholar
  200. 200.
    Clementi M, Riccola S. The effect of the disinfectant AMU2SO vs. hepatitis B virus analyzed using MADT (morphological alteration and disintegration test). Acta Toxicol Ther. 1999;XX:37–42.Google Scholar
  201. 201.
    Fabrizi F, Martin P. Hepatitis B virus infection in dialysis patients. Am J Nephrol. 2000;20:1–11.PubMedCrossRefGoogle Scholar
  202. 202.
    Moyer LA, Alter MJ, Favero MS. Hemodialysis-associated hepatitis B: revised recommendations for serologic screening. Semin Dial. 1990;3:201–4.CrossRefGoogle Scholar
  203. 203.
    Ukena T, Esber H, Bessette R et al. Site of injection and response to hepatitis B vaccine (Letter). N Engl J Med. 1985;313:579–80.PubMedGoogle Scholar
  204. 204.
    Lindsay KL, Herbert DA, Gitnick GL. Hepatitis B vaccine: low post-vaccination immunity in hospital personnel given gluteal injections. Hepatology. 1985;5:1088–90.PubMedCrossRefGoogle Scholar
  205. 205.
    Stevens CE, Alter HJ, Taylor PE et al. Hepatitis B vaccine in patients receiving hemodialysis: immunogenicity and efficacy. N Engl J Med. 1984;311:496–501.PubMedCrossRefGoogle Scholar
  206. 206.
    Jaiswal SB et al. Hepatitis B vaccine in patients on hemodialysis. Lancet. 1995;346:317–18.PubMedCrossRefGoogle Scholar
  207. 207.
    Peces R, de la Torre M, Alcázrr, Urra JM. Prospective analysis of the factors influencing the antibody response to hepatitis B vaccine in hemodialysis patients. Am J Kidney Dis. 1997;29:239–45.PubMedCrossRefGoogle Scholar
  208. 208.
    Khan AN, Bernardini J, Rault RM, Praino B. Low seroconversion with hepatitis B vaccination in peritoneal dialysis patients. Perit Dial Int. 1996;16:370–3.PubMedGoogle Scholar
  209. 209.
    Fabrizi F, Andrulli S, Bacchini et al. Intradermal versus intramuscular hepatitis B re-vaccination in non-responsive chronic dialysis patients: a prospective randomized study with cost-effectiveness evaluation. Nephrol Dial Transplant. 1997;12:1204–11.PubMedCrossRefGoogle Scholar
  210. 210.
    Evans TG, Schiff M, Graves B et al. The safety and efficacy of GM-CSF as an adjuvant in hepatitis B vaccination of chronic hemodialysis patients who have failed primary vaccination. Clin Nephrol. 2000;54:138–42.PubMedGoogle Scholar
  211. 211.
    Kapoor D, Aggarwal SR, Singh NP et al. Granulocyte-macrophage colony-stimulating factor enhances the efficacy of hepatitis B virus vaccine in previously unvaccinated haemodialysis patients. J Vir Hepatitis. 1999;6:405–9.CrossRefGoogle Scholar
  212. 212.
    Dukes CS, Street AC, Starling JF, Hamilton JD. Hepatitis B vaccination and booster in predialysis patients: a 4-year analysis. Vaccine. 1993;11:1229–32.PubMedCrossRefGoogle Scholar
  213. 213.
    Fabrizi F, Di Filippo S, Marcelli D et al. Recombinant hepatitis B vaccine use in chronic hemodialysis patients: long-term evaluation and cost-effectiveness analysis. Nephron. 1996;72:536–43.PubMedCrossRefGoogle Scholar
  214. 214.
    Dentico P, Buongiorno R, Volpe A et al. Long-term immunogenicity and protective efficacy of recombinant DNA yeast-derived vaccine in hemodialysis patients. J Nephrol. 1993;6:95–7.Google Scholar
  215. 215.
    de Graeff PA, Dankert J, De Zeuw D et al. Immune response to two different hepatitis B vaccines in haemodialysis patients: a 2-year follow-up. Nephron. 1985;40:155–60.PubMedCrossRefGoogle Scholar
  216. 216.
    Buti M, Viladomiu L, Jardi R et al. Long-term immunogenicity and efficacy of hepatitis B vaccine in hemodialysis patients. Am J Nephrol. 1992;12:144–7.PubMedCrossRefGoogle Scholar
  217. 217.
    Marangi AL, Giordano R, Montanaro A et al. Hepatitis B virus infection in chronic uremia: long-term follow-up of a two-step integrated protocol of vaccination. Am J Kidney Dis. 1994;23:537–42.PubMedGoogle Scholar
  218. 218.
    Pasko MT, Bartholomew WR, Beam RT et al. Long-term evaluation of the hepatitis B vaccine (Heptavax-B) in hemodialysis patients. Am J Kidney Dis. 1998;11:326–31.Google Scholar
  219. 219.
    Centers for Disease Control. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination. Recommendations of the Immunization Practices Advisory Committee (ACIP) MMWR. 1991;40RR-13:1–25.Google Scholar
  220. 220.
    Task Force on Adult’s Immunization. Guide for Adult Immunization, 3rd edn. Philadelphia: American College of Physicians, 1994.Google Scholar
  221. 221.
    Janzen L, Minuk GY, Fast M, Bernstein KN. Vaccineinduced hepatitis B surface antigen positivity in adult hemodialysis patients: incidental and surveillance data. J Am Soc Nephrol. 1996;7:1228–34.PubMedGoogle Scholar
  222. 222.
    Harnett JD, Parfrey PS, Kennedy M et al. The long-term outcome of hepatitis B infection in hemodialysis patients. Am J Kidney Dis. 1988;11:210–13.PubMedGoogle Scholar
  223. 223.
    Ribot S, Rothstein M, Goldblat M, Grasso M. Duration of hepatitis B surface antigenemia in hemodialysis patients. Arch Intern Med. 1979;139:178–80.PubMedCrossRefGoogle Scholar
  224. 224.
    Koretz RL, Stone O, Mousa M, Gitnick G. The pursuit of hepatitis in dialysis units. Am J Nephrol. 1984;4:222–6.PubMedCrossRefGoogle Scholar
  225. 225.
    Degott C, Degos F, Jungers P et al. Relationship between liver histopathological changes and HbsAg in 111 patients treated by long-term hemodialysis. Liver 1983;3:377–84.PubMedGoogle Scholar
  226. 226.
    Couglin GP, van Deth AG, Jungers P et al. Liver disease and the e antigen in HbsAg carriers with chronic renal failure. Gut. 1980;21:118–22.CrossRefGoogle Scholar
  227. 227.
    Galbraith R, el Sheikh N, Portmann B et al. Immune response to HbsAg and the spectrum of liver lesions in HbsAg-positive patients with chronic renal disease. Br Med J. 1976;1:1495–7.PubMedCrossRefGoogle Scholar
  228. 228.
    Parfrey PS, Farge D, Forbes RDC et al. Chronic hepatitis in end-stage renal disease: comparison of HbsAG-negative and HbsAG-positive patients. Kidney Int. 1985;28:959–67.PubMedCrossRefGoogle Scholar
  229. 229.
    Yasuda K, Okuda K, Endo N et al. Hypoaminotransferasemia in patients undergoing long-term hemodialysis: clinical and biochemical appraisal. Gastroenterology. 1995;109: 1295–300.PubMedCrossRefGoogle Scholar
  230. 230.
    Abou-Saif A, Lewis JH. Gastrointestinal and hepatic disorders in end-stage renal disease and renal transplant recipients. Adv Ren Repl Ther. 2000;7:220–30.CrossRefGoogle Scholar
  231. 231.
    Diestag J, Isselbacker K. Acute viral hepatitis. In: Fauci AS, Braunwald E, Isselbacker KJ et al., editors. Harrison’s Principles of Internal Medicine, 14th edn, Vol. II. New York: McGraw-Hill, 1998:1681.Google Scholar
  232. 232.
    Chenello L, Cavaletto L, Casarin C et al. Persistent hepatitis C viremia predicts late relapse after sustained response to interferon-alfa in chronic hepatitis C. Ann Intern Med. 1996;124:1058–60.CrossRefGoogle Scholar
  233. 233.
    Chiu-Ching H. Hepatitis in patients with end-stage renal disease. J Gastroenterol Hepatol. 1997;12(Suppl.):S236–41.CrossRefGoogle Scholar
  234. 234.
    Okuda K, Hayashi H, Yokozeki K et al. Acute hepatitis C among renal failure patients on chronic haemodialysis. J Gastroenterol Hepatol. 1998;13:62–7.PubMedCrossRefGoogle Scholar
  235. 235.
    Garcia-Valdecasas J, Bernal C, Garcia F et al. Epidemiology of hepatitis C virus infection in patients with renal disease. J Am Soc Nephrol. 1994;5:186–92.PubMedGoogle Scholar
  236. 236.
    Huraib S, Tanimu D, Romeh SA et al. Interferon-alpha in chronic hepatitis C infection in dialysis. Am J Kidney Dis. 1999;34:55–60.PubMedCrossRefGoogle Scholar
  237. 237.
    Pereira BJG. Hepatitis C in organ transplantation. Its significance and influence on transplantation policies. Curr Opin Nephrol Hypertens. 2000;2:912–22.CrossRefGoogle Scholar
  238. 238.
    Gomiz JL, Miguel A, Garcia-Ramon R et al. Prevalence and risk factors for hepatitis C virus infection in continuous ambulatory peritoneal dialysis patients. Nephrol Dial Transplant. 1996;11:1109–12.CrossRefGoogle Scholar
  239. 239.
    Alter MJ, Kruszon-Moran D, Nainan OV et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med. 1999;341:1556–62.Google Scholar
  240. 240.
    Fabrizi F, Martin P, Dixit V et al. Acquisition of hepatitis C virus in hemodialysis patients: a prospective study of branched DNA signal amplification assay. Am J Kidney Dis. 1998;31:647–54.PubMedCrossRefGoogle Scholar
  241. 241.
    Pereira BJG. Hepatitis C virus infection in dialysis: a continuing problem. Artif Organs. 1999;23:51–60.PubMedCrossRefGoogle Scholar
  242. 242.
    Meshari KA, Ahdal MA, Alfurayh O et al. New insights into hepatitis C virus infection of hemodialysis patients: the implications. Am J Kidney Dis. 1995;25:572–8.PubMedCrossRefGoogle Scholar
  243. 243.
    Mitwalli A, al-Mohaya S, al-Wakeel J et al. Hepatitis C in chronic renal failure patients. Am J Nephrol. 1992;12: 288–91.PubMedCrossRefGoogle Scholar
  244. 244.
    Sampietro M, Graziani G, Badalamenti S et al. Detection of hepatitis C virus in dialysate and blood ultrafiltrate of HCVpositive patients. Nephron. 1994;68:140.PubMedCrossRefGoogle Scholar
  245. 245.
    Hubmann R, Zazgornik J, Gabriel Ch et al. Hepatitis C virus — does it penetrate the haemodialysis membrane? Nephrol Dial Transplant. 1995;10:541–2.PubMedGoogle Scholar
  246. 246.
    Jadoul M, Cornu C, Van Ypersele de Strihou C, and the Universitaires Cliniques St-Luc Colloborative Group. Universal precautions prevent hepatitis C virus transmission: a 54 month follow-up of the Belgian multicenter study. Kidney Int. 1998;53:1022–5.PubMedCrossRefGoogle Scholar
  247. 247.
    Jadoul M, Cornu C, van Ypersele de Strihou C et al. Incidence and risk factors for hepatitis C seroconversion in hemodialysis: a prospective study. UCL Colloborative Group. Kidney Int. 1993;44:1322–6.CrossRefGoogle Scholar
  248. 248.
    Mitsui T, Iwano K, Masuko K. Hepatitis C virus infection in medical personnel after needle stick accident. Hepatology. 1992;16:1109–14.PubMedCrossRefGoogle Scholar
  249. 249.
    Stempel CA, Lake J, Kuo G et al. Hepatitis C: prevalence in end-stage renal failure patients and clinical course after kidney transplantation. Transplantation. 1993;55:273–6.PubMedCrossRefGoogle Scholar
  250. 250.
    Centers for Disease Control. CDC recommendations for prevention and control of Hepatits C virus (HCV) infection and HCV-related chronic disease. MMWR. 1998;47:1–40.Google Scholar
  251. 251.
    Simon N, Corouce AM, Lemarrec N et al. A twelve year natural history of hepatitis C virus infection in hemodialyzed patients. Kidney Int. 1994;46:504–11.PubMedCrossRefGoogle Scholar
  252. 252.
    Farci P, Alter HJ, Govindarajan et al. Lack of protective immunity against reinfection with hepatitis C virus. Science. 1992;258:135–40.PubMedCrossRefGoogle Scholar
  253. 253.
    Caramello C, Bartolome J, Albalate M et al. Undiagnosed hepatitis C virus infection in hemodialysis patients: value of HCV RNA and liver enzyme levels. Kidney Int. 1996; 50:2027–31.CrossRefGoogle Scholar
  254. 254.
    Sterling RK, Sanyal AJ, Luketic VA et al. Chronic hepatitis C infection in patients with end-stage renal disease. Characterization of liver histology and viral load in patients awaiting renal transplantation. Am J Gastroenterol. 1999; 94:3576–82.PubMedCrossRefGoogle Scholar
  255. 255.
    De Medina M, Hill M, Sullivan HO et al. Detection of antihepatitis C virus antibodies in patients undergoing dialysis by utilizing a hepatitis C virus 3.0 assay. Correlation with hepatitis C virus RNA. J Lab Clin Med. 1998;132:73–5.PubMedCrossRefGoogle Scholar
  256. 256.
    Morales JM, Campistol JM. Transplantation in the patient with hepatitis C. J Am Soc Nephrol. 2000;11:1343–53.PubMedGoogle Scholar
  257. 257.
    Hoofnagle JH. Hepatitis C: the clinical spectrum of disease. Hepatology. 1997;26(Suppl. 1):15–20.Google Scholar
  258. 258.
    Simon N, Corouce AM, Lemarrec N et al. A twelve year natural history of hepatitis C virus infection in hemodialyzed patients. Kidney Int. 1994;46:504–11.PubMedCrossRefGoogle Scholar
  259. 259.
    Nakayama E, Akiba T, Marumo F, Sato C. Prognosis of anti-hepatitis C virus antibody-positive patients on regular hemodialysis therapy. J Am Soc Nephrol. 2000;11:1896–902.PubMedGoogle Scholar
  260. 260.
    Stehman-Breen CO, Emerson S, Gretch D, Johnson RJ. Risk of death among chronic dialysis patients infected with hepatitis C virus. Am J Kidney Dis. 1998;32:629–34.PubMedCrossRefGoogle Scholar
  261. 261.
    Ferrari C, Urban S, Penna A et al. Immunopathogenesis of hepatitis C virus infection. J Hepatol. 1999;31(Suppl. 1):31–8.PubMedCrossRefGoogle Scholar
  262. 262.
    Okuda K, Yokosuka, Otake Y et al. Cryoglobulinaemia among maintenance haemodialysis patients and its relation to hepatitis C infection. J Gastroenterol Hepatol. 1998;13: 248–52.PubMedCrossRefGoogle Scholar
  263. 263.
    Canavese C, Hollo Z, Ciccone G et al. Extrahepatic immunological manifestations of hepatitis C virus in dialysis patients. J Nephrol. 2000;13:352–9.PubMedGoogle Scholar
  264. 264.
    Huraib S, Tanimu D, Romeh SA et al. Interferon-alpha in chronic hepatitis C infection in dialysis. Am J Kidney Dis. 1999;34:55–60.PubMedCrossRefGoogle Scholar
  265. 265.
    Campistol JM, Esforzado N, Martinez J et al. Efficacy and tolerance of interferon-alpha2b in the treatment of chronic hepatitis C virus infection in haemodialysis patients. Pre and post-renal transplantation assessment. Nephrol Dial Transplant. 1999;14:2704–9.PubMedCrossRefGoogle Scholar
  266. 266.
    Rostaing L, Chatelut E, Payen JL et al. Pharmacokinetics of alphaIFN-2b in chronic hepatitis C virus patients undergoing chronic hemodialysis or with normal renal function: clinical implications. J Am Soc Nephrol. 1998;9:2344–8.PubMedGoogle Scholar
  267. 267.
    Chow WC. Hepatitis C: retreatment and treatment of patients with renal failuire. J Gastroenterol Hepatol Suppl. 2000;May:E152–5.Google Scholar
  268. 268.
    Bruchfeld A, Stahle L, Andersson J, Schvarcz R. Ribavirin treatment in dialysis patients with chronic hepatitis C virus infection — a pilot study. J Vir Hepatitis. 2001;8:287–92.CrossRefGoogle Scholar
  269. 269.
    Alter HJ, Nakatsuji Y, Melpolder J et al. The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N Engl J Med. 1997;336:747–54.PubMedCrossRefGoogle Scholar
  270. 270.
    Alter HJ, Gallagjer M, Morris TT et al. Acute non-A-E hepatitis in the United States and the role of hepatitis G virus infection. N Engl J Med. 1997;336:741–6.PubMedCrossRefGoogle Scholar
  271. 271.
    Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med. 1993;329:332–42.PubMedCrossRefGoogle Scholar
  272. 272.
    Everson GT, Scherzinger A, Berger-Leff N et al. Polycystic liver disease: quantification of parenchymal and cyst volumes from computed tomography images and clinical correlates of hepatic cysts. Hepatology. 1988;8:1627–34.PubMedCrossRefGoogle Scholar
  273. 273.
    Newman KD, Torres VE, Rakela I et al. Treatment of highly symptomatic polycystic liver disease. Ann Surg. 1990;212: 30–7.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Joyce Gonin
  • Chagriya Kitiyakara
  • Alfonso Santos

There are no affiliations available

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