Biosynthesis of cobalamins including vitamin B12

  • Georges N. Cohen


Vitamin B 12 can be formally classified with the tetrapyrrole derivatives. It is based on a skeleton called corrin (Fig. 1), which differs from the other tetrapyrroles in the absence ot a methene bridge between two of the pyrrole rings. In numbering the atoms in this formula, number 20 has been deliberately omitted, in order that all the corrin atoms should correspond to those of the other tetrapyrrole compounds. Some of the biosynthetic intermediates occurring before the formation of hydrogenobyrinic acid are called precorrins.


Complementation Group Tetrapyrrole Compound Corrin Ring Diol Dehydratase Tetrapyrrole Ring 
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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Georges N. Cohen
    • 1
    • 2
  1. 1.Centre National de la Recherche ScientifiqueParisFrance
  2. 2.Institut PasteurParisFrance

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