Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid
The use of appropriate mutants and an adequate enzyme analysis has enabled to decide which of these amino acids is synthesized first, since the final step in the pathway, the interconversion of serine and glycine, is catalyzed by a single enzyme, serine hydroxymethyltransferase, and since mutations affecting the biosynthesis of serine result in a nutritional requirement which can be satisfied by one or the other of these amino acids. However mutations deficient in hydroxymethyltransferase require specifically glycine and cannot grow with serine.
KeywordsPyruvic Acid Pyridoxal Phosphate Alcaligenes Faecalis Serine Hydroxymethyltransferase Phosphoglyceric Acid
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Valine and Leucine
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