The ribosomes

  • Georges N. Cohen


In the 1930s, cell biologists had surmised that the greatest part of RNA was localized in the cytoplasm and that there was a correlation between the amount of RNA and the protein synthesizing capacity of the cell. In the 1940s, Brachet and Caspersson established unequivocally this correlation with materials as diverse as the root tips of Allium cepa, imaginal disks of Drosophila larvae, secreting pancreatic cells and silk glands from the silkworm and with various methods such as specific dying techniques, specific nucleases and spectrophotometric methods on thin tissue slices.


Ribosomal Subunit Imaginal Disk Silk Gland Sedimentation Coefficient Initiation Complex 
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Selected references


  1. The ribosome: structure, function and evolution, Walter E. Hill, Albert Dahlberg et al., American Society for Microbiology, 678 pp. (1990).Google Scholar

Eukaryotic ribosomes

  1. I. G. Wool, Ann. Rev. Biochem., 48, 719 - 754 (1979).PubMedCrossRefGoogle Scholar


  1. A. Yonath, Annu. Rev. Biophys. Biomol. Struct., 31, 257 - 273Google Scholar
  2. J. M. Ogle, F. V. Murphy, M. J. Tarry and V. Ramakrishnan, Cell. 111, 721 - 732 (2002).PubMedCrossRefGoogle Scholar
  3. A. Yonath, Curr. Protein. Pept. Sci., 3, 67 - 78 (2002).Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Georges N. Cohen
    • 1
    • 2
  1. 1.Centre National de la Recherche ScientifiqueParisFrance
  2. 2.Institut PasteurParisFrance

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