Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases

  • Michael H. Weber
  • Jonathan C. Sharp
  • Thomas H. Hassard
  • Martin Reed
  • James A. Thliveris
  • F. William Orr
Part of the Cancer Metastasis — Biology and Treatment book series (CMBT, volume 6)


Breast cancer is a leading cause of death in women, occurring in one of eight during their lifetime. A comparable cancer in men, prostate cancer, claims the lives of just under 30,000 men in the United States each year with a prevalence of one in six (1). These tumors, along with carcinomas of the lung, thyroid, and kidney have a high propensity to metastasize to bone, which constitutes one of their most serious complications, creates a great challenge for treatment, and often carries a poor prognosis. Metastases are the most frequent bone tumors and cause significant morbidity due to pain, osteolysis, pathological fractures, hypercalcemia, and anemia (2). Established bone metastases are resistant to treatment and current therapeutic approaches such as endocrine therapy, radiation therapy, and chemotherapy are often ineffective (3). This chapter has been written on the premise that a better understanding of the pathophysiology of bone metastasis may provide insight into the design of diagnostic techniques that would help to identify bone metastasis formation at its earliest stages. This may provide an opportunity for early treatment and alleviate the necessity to treat them at a late stage.


Prostate Cancer Bone Metastasis Prostate Specific Antigen Circulate Tumor Cell Bone Scintigraphy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Michael H. Weber
    • 1
    • 4
  • Jonathan C. Sharp
    • 4
  • Thomas H. Hassard
    • 2
  • Martin Reed
    • 5
  • James A. Thliveris
    • 3
  • F. William Orr
    • 1
  1. 1.The Department of PathologyUniversity of ManitobaWinnipegCanada
  2. 2.Department of Community Health ScienceUniversity of ManitobaWinnipegCanada
  3. 3.Department of Human Anatomy and Cell ScienceCanada
  4. 4.Institute for BiodiagnosticsNational Research Council of CanadaWinnipegCanada
  5. 5.The Department of RadiologyHealth Sciences CentreWinnipegCanada

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