Laboratory Experiments

Experiment 10 The Preparation, Characterisation and Screening of Pharmaceutically Active Metal Complexes
  • Ei-Ichiro Ochiai
  • David R. Williams


The last decade has seen an upsurge of interest in trace-element medicine. On the one hand this may involve adjusting the concentration of an essential or beneficial element to a figure that produces optimum health. On the other hand, this might involve administering a compound of an element not normally found in the body to stimulate the body to rid itself of an invading organism such as viruses, bacteria or cancer cells. Compounds of Group VIII in the transition series are particularly effective in this respect. The most widely known metal complex carcinostat is cis-dichlorodiammineplatinum(II) whereas substituting water molecules in place of the two chlorides gives a viable antiviral agent. Finally, some negatively charged compounds such as the hexachloroplatinate(IV) anion have marked bactericidal activity. Clearly, we cannot cover all aspects of the preparation, characterisation and screening of these drugs but we can illustrate some aspects.


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Copyright information

© Ei-Ichiro Ochiai and David R. Williams 1979

Authors and Affiliations

  • Ei-Ichiro Ochiai
    • 1
  • David R. Williams
    • 2
  1. 1.Department of ChemistryUniversity of British ColumbiaCanada
  2. 2.Department of ChemistryUniversity of Wales Institute of Science and TechnologyCardiffUK

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