Abstract
The idea that a rational strategy for chemotherapy depends on selecting for chemical agents that are toxic to the parasite but not to the host was originally established by Paul Ehrlich in the early part of this century. While pharmacologists have always recognized Ehrlich’s basic concept of selective toxicity, the invading organism was looked upon for many years as a ‘black box’ subject. During the last twenty years it has become evident that knowledge of the biochemistry of the invading organism is of prime importance in implementing Ehrlich’s strategy for chemotherapy. Knowledge about the biochemistry and genetics of bacterial and viral species has led to the development of selective chemotherapeutic agents against the invading organism. Even when an antibacterial or antiviral agent is discovered as the result of a ‘blind’ screening programme it has often been possible to identify the site of action of these new chemotherapeutic agents. Such studies in many cases have led to the uncovering of new sites in the invading organism that are amenable to further pharmacological manipulation.
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Mansour, T.E. (1984). Intermediary metabolism and its regulation in parasitic worms in a strategy for chemotherapy. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-86029-6_47
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DOI: https://doi.org/10.1007/978-1-349-86029-6_47
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