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The contribution of covalent binding and lipid peroxidation in the pathogenesis of fatty liver by CCl4

  • M. U. Dianzani
  • U. M. Marinari
  • G. Poli
Chapter

Abstract

It is now well known that CCl4 is metabolised by the smooth endoplasmic reticulum of liver cell with the production of the trichloromethyl radical (CCI3) (Slater, 1978). The direct demonstration of the generation of such a reactive metabolite has been given by electron spin resonance studies (Tomasi et al., 1980; Poyer et al., 1980). In addition, with pulse radiolysis techniques, the rapid conversion of CCI3, in the presence of O2, into CCl3O2, the trich-loromethylperoxy radical, has been demonstrated (Packer et al., 1978,1980).

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • M. U. Dianzani
    • 1
  • U. M. Marinari
    • 2
  • G. Poli
    • 1
  1. 1.Institute of General PathologyUniversity of TorinoTorinoItaly
  2. 2.Institute of General PathologyUniversity of GenovaGenovaItaly

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