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Endogenous substrates and inhibitors of monoamine oxidase

  • M. Sandler
  • V. Glover
  • J. D. Elsworth
Chapter

Abstract

Monoamine oxidase (MAO) (EC 1.4.3.4) acts on a wide range of endogenous monoamine substrates including the neurotransmitters, noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT) and adrenaline (see Costa & Sandler, 1972), tele-methylhistamine (Elsworth et al, 1980) and the ‘trace amines’, phenylethylamine (PEA), phenyl-ethanolamine, o-, m- and p-tyramine, tryptamine, 5-methoxytryptamine, N-methyltryptamine, di-methyltryptamine and the octopamines (Usdin & Sandler, 1976; Boulton et al, 1984), and the list is by no means complete. Unlike DA, NA and 5-HT, which are present in the rat brain in a concentration of the order of 500 ng g_1, the trace amines are only represented at a level of less than 10 ng g_1, and as yet have no proven role. Although it is possible that they are merely byproducts of metabolism, without biological function, it seems rather more likely that some act in a modulatory fashion in connection with specific neuronal pathways.

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • M. Sandler
  • V. Glover
  • J. D. Elsworth

There are no affiliations available

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