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IUPHAR 9th International Congress of Pharmacology pp 157–162Cite as

The role of inositol phospholipid turnover in the actions of peptide secretagogues

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Abstract

Although the role of calcium in stimulus-secretion coupling was established by the independent efforts of William Douglas (Douglas, 1968) and Sir Bernard Katz (Katz, 1969) two to three decades ago, the various steps in this process are still poorly understood. One approach to elucidating the nature of the cellular events associated with activation of secretion concerns the turnover of membrane phospholipids. Particular attention has focused on a relatively minor membrane component, phosphatidylinositol (PI), with regard to its participation in receptor-response coupling in diverse cell types, including those specialized to secrete. Thus, both the turnover of the polar head group and arachidonic acid in position 2 of PI—which are catalysed by phospholipase C and A2, respectively—have been implicated in events associated with the secretory process (Laychock & Putney, 1982).

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Authors and Affiliations

  1. Department of Pharmacology, Medical College of Virginia, Richmond, Virginia, 23298-0001, USA

    R. P. Rubin & P. G. Bradford

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  1. R. P. Rubin
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  2. P. G. Bradford
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William Paton James Mitchell Paul Turner

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© 1984 Macmillan Publishers Limited

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Rubin, R.P., Bradford, P.G. (1984). The role of inositol phospholipid turnover in the actions of peptide secretagogues. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-86029-6_24

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