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Discovery and clinical evaluation of novel antihypertensive drugs

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IUPHAR 9th International Congress of Pharmacology

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Abstract

Twelve years ago a protocol for clinical trial of an investigational drug intended for the treatment of severe hypertension was submitted to the Human Studies Committee of one of the foremost research hospitals in the United States. The committee declined to authorize the study because in their judgement no clinical need existed for additional antihypertensive agents. Physicians who treat hypertensive patients could not then and cannot yet live in such a fool’s paradise.

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References

  • BAUER, J.H. & BROOKS, CS. (1979). The long-term effect of propranolol therapy on renal function. Am. J. Med., 66, 405–410.

    Article  Google Scholar 

  • BRECKENRIDGE, A. (1983). Compliance of hypertensive patients with pharmacological treatment. Hypertension, 5 (Supp. 3), 85–89.

    Article  Google Scholar 

  • BRUNNER, H.R., WAEBER, B. & NUSSBERGER, J. (1983). Does pharmacological profiling of a new drug in normotensive volunteers provide a useful guideline to antihypertensive therapy? Hypertension, 5 (Supp. 3), 101–107.

    Article  Google Scholar 

  • BÃœHLER, F.R. (1983). Age and cardiovascular response adaptation. Determinants of an antihypertensive treatment concept primarily based on beta-blockers and calcium entry blockers. Hypertension, 5 (Supp. 3), 94–100.

    Article  Google Scholar 

  • BÃœHLER, F.R., BERTEL, O. & LÃœTOLD, B.E. (1978). Simplified and stratified antihypertensive therapy based on betablockers. Cardiovasc. Med., 3, 135–148.

    Google Scholar 

  • BÃœHLER, F.R., HULTHÉN, U.L., KIOWSKI, W., MÃœLLER, F.B. & BOLLI, P. (1982). The place of the calcium antagonist verapamil in antihypertensive therapy. J. Cardiovasc. Pharmac, 4, S350–S357.

    Article  Google Scholar 

  • DOLLERY, CT. (1983). Hypertension and new antihypertensive drugs: clinical perspectives. Fedn Proc, 42, 207–210.

    Google Scholar 

  • ERNE, P., BOLLI, P., BERTEL, O., HULTHÉN, U.L., KIOWSKI, W., MÃœLLER, F.B. & BÃœHLER, F. (1983). Factors influencing the hypotensive effects of calcium antagonists. Hypertension, 5 (Supp. 2), 97–102.

    Article  Google Scholar 

  • GROSS, F. (1982). Can we develop new drugs for hypertension? Br. J. clin. Pharmac, 13, 133–136.

    Article  Google Scholar 

  • KOCH-WESER, J. (1973). Correlation of pathophysiology and pharmacotherapy in primary hypertension. Am. J. Cardiol., 32, 49–510.

    Article  Google Scholar 

  • KOCH-WESER, J. (1974). Vasodilator drugs in the treatment of hypertension. Archs intern. Med., 133, 1017–1027.

    Article  Google Scholar 

  • KOCH-WESER, J. (1979). Treatment of hypertension in the elderly. In Drugs and the Elderly. Crooks, J. & Stevenson, LH. (eds), pp. 247–262, London: Macmillan.

    Chapter  Google Scholar 

  • KOCH-WESER, J. (1980). Individualization of antihypertensive treatment. In Clinical Pharmacology & Therapeutics, Proceedings of the First World Conference, Turner, P. (ed.), pp. 251–255, London: Macmillan.

    Chapter  Google Scholar 

  • LUND-JOHANSEN, P. (1977). Hemodynamic alterations in hypertension-spontaneous changes and effects of drug therapy. A review. Acta med. scand., 603, 1–14l.

    Google Scholar 

  • LUND-JOHANSEN, P. (1983). Hemodynamic response: decrease in cardiac output versus reduction in vascular resistance. Hypertension, 5 (Supp. 3), 49–57.

    Article  Google Scholar 

  • SOLOMON, S., HOTCHKISS, E., SARAVAY, S.M., BAYER, C, RAMSEY, R. & BLUM, R.S. (1983). Impairment of memory function by antihypertensive medication. Arch. gen. Psych., 40, 1109–1112.

    Article  Google Scholar 

  • STEVENSON, J.G. & UMSTEAD, G.S. (1984). Antihypertensive drugs and sexual dysfunction. Drug Intell. Clin. Pharmacy, 18, 113–121.

    Google Scholar 

  • TRAP-JENSEN, J., CLAUSEN, J.P. & NOER, I. (1975). Regional hemodynamic changes during exercise in essential hypertension before and after prolonged beta-receptor blockade. Scand. J. clin. lab. Invest., 35, 143–160.

    Google Scholar 

  • URQUHART, J., FARA, J.W. & WILLIS, K.L. (1984). Rate-controlled delivery systems in drug and hormone research. Ann. Rev. Pharmac. Toxicol., 24, 199–236.

    Article  Google Scholar 

  • WEIDMANN, P., GERBER, A. & MORDASINI, R. (1983). Effects of antihypertensive therapy on serum lipoproteins. Hypertension, 5 (Supp. 3), 120–131.

    Google Scholar 

  • ZANDBERG, P. (1984). Animal models in experimental hypertension: relevance to drug testing and discovery. In Handbook of Hypertension, vol. 3, Pharmacology of Antihypertensive Drugs, van Zwieten, P.A. (ed.), pp. 6–45, Amsterdam: Elsevier.

    Chapter  Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Research, F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basel, Switzerland

    J. Koch-Weser

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  1. J. Koch-Weser
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William Paton James Mitchell Paul Turner

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© 1984 Macmillan Publishers Limited

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Koch-Weser, J. (1984). Discovery and clinical evaluation of novel antihypertensive drugs. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-86029-6_16

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