Physicochemical properties in structure-activity analysis

  • M. S. Tute


Prominent among the methods of relating structure to biological activity, in order to rationalise drug activity and to predict novel analogues for synthesis, is the quantitative approach popularly known as Hansch Analysis (Hansch et al., 1963; Hansch, 1981). In Hansch Analysis, the biological activities of a parent molecule and a series of simple derivatives are subjected to regression analysis to find an equation relating activity to some combination of parameters representing changes in hydrophobic, electronic, and steric effects within the series. This enables conclusions to be drawn regarding the influence of physicochemical properties on drug transport or on drug binding.


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© Macmillan Publishers Limited 1984

Authors and Affiliations

  • M. S. Tute
    • 1
  1. 1.Pfizer Central ResearchPfizer LtdKentUK

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