Compartmentation of Citrate in Heart and Adipose Tissue
The compartmentation of citrate between mitochondrial and cytoplasmic compartments of the cell is an important area of investigation in the study of mechanisms of metabolic control in both heart and adipose tissue. In both tissues the only site of citrate synthesis is within mitochondria but citrate has important metabolic functions in the cytoplasm: in heart muscle citrate is thought to be important in the control of phosphofructokinase; in adipose tissue citrate is the means of transferring acetyl units, and possibly also reducing power, to the cytoplasm.
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