Abstract
Three main factors determine the efficient transport of oxygen from the atmosphere to the metabolising tissues — the integrity of the lungs and of the circulation, and the carriage of oxygen by the blood. Haemoglobin in the blood also has an important role in one other common respiratory function test, the Diffusing Capacity for carbon monoxide. Abnormalities may arise from a haemoglobin concentration which is either too low or too high or from the presence of haemoglobin with an abnormal molecular structure.
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References
Severinghaus, J. W. Blood gas concentrations. In: Fenn, W. O. and Rahn, H. (eds), Handbook of Physiology, section 3, Respiration, vol. II, Baltimore: American Physiological Society, 1965: 1475–87.
Housley, E. Respiratory gas exchange in chronic anaemia. Clin. Sci. 1967; 32: 19–26.
Guleria, J. S., Pande, J. N., Markose, M. M. et al. Pulmonary function in chronic severe anaemia. Clin. Sci. 1971; 40: 317–25.
Roughton, F. J. W. and Forster, R. E. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J. Appl. Physiol. 1957; 11: 290–302.
Cotes, J. E., Dabbs, J. M., Elwood, P. C. et al. Iron-deficiency anaemia: its effect on Transfer Factor for the lung (Diffusing Capacity) and ventilatory and cardiac frequency during sub-maximal exercise. Clin. Sci. 1972; 42: 325–35.
Clark, E. H., Woods, R. L. and Hughes, J. M. B. Effect of blood transfusion on the carbon monoxide transfer factor of the lung in man. Clin. Sci. 1978; 54: 627–31.
Dinakara, P., Blumenthal, W. S., Johnston, R. F. et al. The effect of anaemia on pulmonary diffusing capacity with derivation of a correction equation. Am. Rev. Respir. Dis. 1970; 102: 965–9.
Burgess, J. H. and Bishop, J. M. Pulmonary diffusing capacity and its subdivisions in polycythaemia vera. J. Clin. Invest. 1963; 42: 997–1006.
Lertzmann, M., Frome, B. M., Israel, L. G. and Cherniack, R. M. Hypoxia in polycythaemia vera. Ann. Int. Med. 1964; 60: 409–17.
Murray, J. F. Arterial studies in primary and secondary polycythaemic disorders. Am. Rev. Respir. Dis. 1965; 92: 435–49.
Greening, A. P., Patel, K., Goolden, A. W. G. et al. Carbon monoxide diffusing capacity in polycythaemia rubra vera. Thorax 1982; 37: 528–31.
Miller, G. J. and Serjeant, G. R. An assessment of lung volumes and gas transfer in sickle-cell anaemia. Thorax 1971; 26: 309–15.
Miller, G. J., Serjeant, G. R. and Saunders, M. J. et al. Interpretation of lung function tests in the sickle-cell haemoglobinopathies. Thorax 1978; 33: 85–88.
Bromberg, P. A. and Jensen, W. N. Arterial oxygen unsaturation in sickle-cell disease. Am. Rev. Respir. Dis. 1967; 96: 400–7.
Cooper, D. M., Mansell, A. L., Weiner, M. A. et al. Low lung capacity and hypoxaemia in children with thalassaemia major. Am. Rev. Respir. Dis. 1980; 121: 639–46.
Bellingham, A. J. Haemoglobins with altered oxygen affinity. Br. Med. Bull. 1976; 32: 234–8.
Hebbel, R. P., Kronenberg, R. S. and Eaton, J. W. Hypoxic ventilatory response in subjects with normal and high oxygen affinity haemoglobins. J. Clin. Invest. 1917; 60: 1211–15.
Rossoff, L. J., Rebuck, A. S. and Aberman, A. The hypoxic ventilatory response in patients with high affinity hemoglobin. Am. Rev. Respir. Dis. 1980; 121: 170–2.
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© 1984 G. J. Gibson
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Gibson, G.J. (1984). Blood disorders. In: Clinical Tests of Respiratory Function. Palgrave, London. https://doi.org/10.1007/978-1-349-81333-9_12
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DOI: https://doi.org/10.1007/978-1-349-81333-9_12
Publisher Name: Palgrave, London
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