Substance Misuse and Tissue Pathology with Special Reference to the Heart

  • Victor R. Preedy
  • Howard Why
  • Vinood Patel
  • Adrian Bonner
  • Peter Richardson


Common drugs of misuse include alcohol, nicotine (and tobacco products), cannabis, cocaine and, to a certain extent, caffeine. Other lesser used drugs include amphetamines, opiates, sedatives/hypnotics, phencyclidines, hallucinogens and anabolic steroids. In Europe there are many millions of drug misusers and, similarly, the extent of drug misuse in North America is staggering. Thus, in the UK there are between 1 and 3 million alcohol abusers and a third of the adult population smoke tobacco products. The biomedical implications of this prevalence are considerable. In comparison with psychomotor, neuropsychiatric and cognitive reports on the above substances, investigations into organ damage are comparatively limited. This particularly relates to the biochemical mechanisms responsible for tissue specific lesions. It is a truism that virtually every single tissue system or organ in the mammalian body is adversely affected to some degree by one or more of the above drugs of misuse. At the extreme, there is organ failure and death. At the very least, there may arise compensatory mechanisms, that may be considered to be either adaptive or destructive but, nevertheless, impair organ function.


Coffee Consumption Addictive Behaviour Substance Misuse Cocaine Abuse Chronic Cocaine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adrian Bonner and James Waterhouse 1996

Authors and Affiliations

  • Victor R. Preedy
  • Howard Why
  • Vinood Patel
  • Adrian Bonner
  • Peter Richardson

There are no affiliations available

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