Skip to main content
SpringerLink
Log in

Principles of Drug Absorption and Routes of Administration

  • Chapter
Physicochemical Principles of Pharmacy

  • 196 Accesses

Abstract

We will deal here with the process of drug absorption from different sites in the body. Drug absorption, whether it be from the gastro-intestinal tract or from the buccal mucosa, requires the passage of the drug in a molecular form across the barrier membrane. Most drugs are presented to the body as solid or semisolid dosage forms and these must first release their drug content. Drug must then dissolve and, if it has the appropriate physical properties, will pass from a region of high concentration to a region of low concentration across the membrane surrounding the site of absorption into the blood (figure 9.1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Nakano et al. Chem. pharm. Bull., 24, 2345 (1977)

    Article  Google Scholar 

  2. K. H. Sterzel et al Trans, am. Soc. artif. intern. Organ, 17, 293 (1971)

    Google Scholar 

  3. A. L. Rubin et al. J. clin. Pharmac., 13, 309 (1973)

    Google Scholar 

  4. E. J. Lien. Drug Intell clin. Pharm., 4, 7 (1970)

    Google Scholar 

  5. E.J. Lien, ibid, 5, 38 (1971)

    Google Scholar 

  6. E. J. Lien, ibid, 8, 470 (1974)

    Google Scholar 

  7. J. G. Wagner and A. J. Sedman. J. Pharmacokin. Biopharm., 1, 23 (1973)

    Article  Google Scholar 

  8. M. L. Lucas, W. Schneider, F. J. Haberich and J. A. Blair. Proc. r. Soc. Lond., 192B, 39 (1976)

    Google Scholar 

  9. M. L. Lucas, J. A. Blair et al. Biochem. Soc. Trans., 4, 154 (1976)

    Article  Google Scholar 

  10. A. Benn et al. Br. med. J., 1, 148 (1971)

    Article  Google Scholar 

  11. H. Ochsenfahrt and D. Winne. N. S Arch. Pharmac., 281, 197 (1974)

    Article  Google Scholar 

  12. J. M. Dietschy and H. Westergaard. Intestinal Absorption and Malabsorption, (ed. T. Z. Csaky), Raven Press, New York, 1975

    Google Scholar 

  13. S. Miyazahi et al. Chem. pharm. Bull., 23, 2151 (1975)

    Article  Google Scholar 

  14. M. Gibaldi and B. Grundhofer. J. pharm. Sci., 62, 343 (1973)

    Article  Google Scholar 

  15. L. S. Murthy and G. Zografi. J. pharm. Sci., 59, 1281 (1970)

    Article  Google Scholar 

  16. M. S. Losowsky et al Malabsorption in Clinical Practice, Longman, London, 1974

    Google Scholar 

  17. R. G. Crounse. J. invest. Derm., 37, 520 (1961)

    Article  Google Scholar 

  18. M. Kraml et al. Can. J. Biochem. Physiol., 40, 1449 (1962)

    Article  Google Scholar 

  19. A. R. Cooke. Gastroenterology, 68, 804 (1975)

    Google Scholar 

  20. D. Greenblatt and J. Koch-Weser. New Engl J. Med., 295, 542 (1976)

    Article  Google Scholar 

  21. T. F. O’Donnell. Lancet, 217, 533 (1975)

    Article  Google Scholar 

  22. P. Turner. Pharm. J., 217, 583 (1976)

    Google Scholar 

  23. R. Luft (ed.) Insulin, Nordisk, Denmark, 1976

    Google Scholar 

  24. B. W. Barry, Pharm. J., 215, 322 (1975)

    Google Scholar 

  25. A. S. Michaels et al. A. I. Chem. J., 21, 985 (1975)

    Google Scholar 

  26. R. Scheuplein. J. invest. Derm., 67, 672 (1976)

    Article  Google Scholar 

  27. A. H. Fenton and M. Warren. Pharm. J., 188, 5 (1962)

    Google Scholar 

  28. N. J. van Abbé, R. I. C. Spearman and A Jarrett. Pharmaceutical and Cosmetic Products for Topical Administration, Heinemann, London, 1969

    Google Scholar 

  29. B. J. Poulsen. Drug Design, vol. IV (ed. E. J. Ariens), Academic Press, New York, 1973, pp. 149 et seq.

    Chapter  Google Scholar 

  30. T. Higuchi. J. Soc. cosmetic Chem., 11, 85 (1960)

    Google Scholar 

  31. J. Ostrenga and J. Haleblian et al. J. invest. Derm., 56, 392 (1971)

    Article  Google Scholar 

  32. M. Busse. Pharm. J., 220, 25 (1978)

    Google Scholar 

  33. J. E. Shaw, S. K. Chandraseharan and L. Taskovich. Pharm. J., 215, 325 (1975)

    Google Scholar 

  34. A. H. Beckett et al. J. Pharm. Pharmac., 24, 65P (1972)

    Article  Google Scholar 

  35. Anon, Lancet, ii, 1287 (1976)

    Google Scholar 

  36. P. H. O’Connor Davies. The Actions and Uses of Ophthalmic Drugs, Barrie and Jenkins, London, 1972

    Google Scholar 

  37. J. Vale and B. J. Cox. Drugs and the Eye, Butterworth, London, 1978

    Google Scholar 

  38. J. W. Seig and J. R. Robinson. J. pharm. Sci., 66, 1222 (1977)

    Article  Google Scholar 

  39. S. I. Rapoport. Blood Brain Barrier, Raven Press, New York, 1976

    Google Scholar 

  40. S. S. Chrai and J. R. Robinson. J. pharm. Sci., 65, 437 (1976)

    Article  Google Scholar 

  41. E. S. Wang and E. R. Hammerlund. ibid., 59, 1559 (1970)

    Article  Google Scholar 

  42. S. R. Waltman and H. E. Jaufman. J. invest. Ophthalmol., 9, 250 (1970)

    Google Scholar 

  43. D. S. Hull, H. F. Edelhauser and R. A. Hyndiuk. Arch. Ophthalmol., 92, 413 (1974)

    Article  Google Scholar 

  44. A. S. Michaels, W. J. Mader and C. R. Manning. Quality Control of Medicines (ed. P. B. Deasy and R. F. Timoney), Elsevier, Amsterdam, 1976, pp. 45–64

    Google Scholar 

  45. E. German and N. Siddiqui. New Engl. J. Med., 282, 689 (1970)

    Google Scholar 

  46. V. Borromeo-McGrail et al. Paediatrics, 51, 1032 (1973)

    Google Scholar 

  47. Anon. Br. med. J., 1, 2 (1974)

    Google Scholar 

  48. C. A. Squier and N. W. Johnson. Br. med. Bull., 31, 169 (1975)

    Google Scholar 

  49. W. R. Galey et al. J. invest. Derm., 67, 713 (1976)

    Article  Google Scholar 

  50. A. H. Beckett and E. J. Triggs. J. Pharm. Pharmac., 19, 31S (1967)

    Google Scholar 

  51. E. H. Dobbs, G. F. Blane and A. L. A. Bovra. Eur. J. Pharmac., 7, 328 (1969)

    Article  Google Scholar 

  52. M. Gibaldi and J. L. Kanig. J. oral Ther. Pharmac., 1, 440 (1965)

    Google Scholar 

  53. C. F. Spiers. Br. J. clin. Pharmac., 4, 97 (1977)

    Article  Google Scholar 

  54. A. H. Beckett and A. C. Moffat. J. Pharm. Pharmac., 22, 15 (1970); 23, 15 (1971)

    Article  Google Scholar 

  55. J. S. G. Cox et al. Adv. Drug. Res., 5, 115 (1970)

    Google Scholar 

  56. T. F. Hatch and P. Gross. Pulmonary Disposition and Retention of Inhaled Aerosols, Academic Press, New York, 1964

    Google Scholar 

  57. S. M. Cohn et al. Inhaled Particles and Vapours (ed. C. N. Davies), Pergamon, London, 1961, p. 178

    Google Scholar 

  58. S. Godfrey, E. Zeidiford, K. Brown and J. H. Bell. Clin. Sci. mol. Med., 46, 265 (1974)

    Google Scholar 

  59. J. A. Burton and L. S. Shanker. Steroids, 23, 617 (1974)

    Google Scholar 

  60. K. M. Jones and G. F. Moss. Excerpta Medica International Congress Series No. 311, vol. XV, 1974, p. 269

    Google Scholar 

  61. G. F. Moss et al. Toxicol. appl. Pharmac., 17, 691 (1970)

    Article  Google Scholar 

  62. J. H. Bell. Mfg. Chem., 38 (9), 37 (1967)

    Google Scholar 

  63. D. S. Freestone and A. L. Weinberg. Br. J. clin. Pharmac., 3, 827 (1976)

    Article  Google Scholar 

  64. G. Thomas. Lancet, i, 400 (1975)

    Article  Google Scholar 

  65. G. J. Gibson et al. Br. med. J., 4, 503 (1974)

    Article  Google Scholar 

  66. N. Senior. Adv. pharm. Sci., 4, 363 (1974)

    Google Scholar 

  67. H. A. Lieberman and J. Anschel. Theory and Practice of Industrial Pharmacy (ed. L. Lachman et al.), Lea and Febiger, Philadelphia, 1970, pp. 538 et seq.

    Google Scholar 

  68. B. R. Guillot and A. P. Lombard. The Suppository, 1st English Edition, Maloine, Paris, 1973

    Google Scholar 

  69. A. Moes. J. Pharm. belg., 29, 319 (1974)

    Google Scholar 

  70. F. Jaminet. The Suppository (ed. B. R. Guillot and A. P. Lombard), Maloine, Paris, 1973, p.111 et seq.

    Google Scholar 

  71. K. Kakemi, H. Sezaki, S. Muranishi and H. Matsui. Chem. pharm. Bull., 15, 172 (1967)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutics, University of Strathclyde, UK

    A. T. Florence

  2. Department of Pharmacy, University of Manchester, UK

    D. Attwood

Authors
  1. A. T. Florence
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Attwood
    View author publications

    You can also search for this author in PubMed Google Scholar

Copyright information

© 1981 A.T. Florence and D. Attwood

About this chapter

Cite this chapter

Florence, A.T., Attwood, D. (1981). Principles of Drug Absorption and Routes of Administration. In: Physicochemical Principles of Pharmacy. Palgrave, London. https://doi.org/10.1007/978-1-349-19480-3_9

Download citation

Publish with us

Policies and ethics

Search

Navigation