An understanding of the process of solution and the factors governing the solubility of drugs and adjuvants is important in pharmaceutics for several reasons. Drugs must sometimes be formulated in solution form or may be added in powder or solution form to liquids such as infusion fluids where they must be maintained in solution. In whatever way drugs may be presented to the body they must nearly always be in a molecularly dispersed form, that is, they must have dissolved, before absorption can occur across biological membranes. The process of solution has therefore frequently to precede absorption unless the drug is administered in solution form; even ingested solutions may form precipitates in the gut contents, and the drug will then have to redissolve. Drugs of low aqueous solubility frequently present problems in relation to their bioavailability.
Unable to display preview. Download preview PDF.
- 7.F. Franks, in Water Relations of Foods (ed. R.D. Duckworth), Academic Press, London, (1975)Google Scholar
- 13.S.A. Khalil, O.Y. Abdallah and M.A. Moustafa. Can. J. pharm. Sci., 11, 26 (1976)Google Scholar
- 15.E.M. Boyd. Predictive Toxicometries, Scientechnica, Bristol, 1972Google Scholar
- 16.J.B. Stenhke. Pharm. J., 215, 533 (1975)Google Scholar
- 17.Burroughs Wellcome. Septrin for InfusionsGoogle Scholar
- 19.A.F. Kaul and J.C. Harsfield. Drug Intell. clin. Pharm., 10, 53 (1976)Google Scholar
- 25.L.B. Holder and S.L. Hayes. Mol. Pharmac., 1, 266 (1965)Google Scholar
- 27.S.I. Rapoport. Blood Brain Barrier in Physiology and Medicine, Raven Press, New York, 1976Google Scholar
- 30.B.A. Edelman, A.V. Contractor and R.F. Shangraw. J. am. pharm. Ass., 60, 30 (1971)Google Scholar