Solubility of Drugs in Liquids

  • A. T. Florence
  • D. Attwood
Chapter

Abstract

An understanding of the process of solution and the factors governing the solubility of drugs and adjuvants is important in pharmaceutics for several reasons. Drugs must sometimes be formulated in solution form or may be added in powder or solution form to liquids such as infusion fluids where they must be maintained in solution. In whatever way drugs may be presented to the body they must nearly always be in a molecularly dispersed form, that is, they must have dissolved, before absorption can occur across biological membranes. The process of solution has therefore frequently to precede absorption unless the drug is administered in solution form; even ingested solutions may form precipitates in the gut contents, and the drug will then have to redissolve. Drugs of low aqueous solubility frequently present problems in relation to their bioavailability.

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Copyright information

© A.T. Florence and D. Attwood 1981

Authors and Affiliations

  • A. T. Florence
    • 1
  • D. Attwood
    • 2
  1. 1.Department of PharmaceuticsUniversity of StrathclydeUK
  2. 2.Department of PharmacyUniversity of ManchesterUK

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