• Bernard T. Donovan


‘Stress’ is a familiar concept that upon analysis becomes a very difficult term to define, for it is necessary to consider the stimulus, the internal reactions to the stimulus, and the responses of the individual to the stimulus. Some assess stress on the basis of the changes in adrenal hormone secretion produced by a particular stimulus, thus focusing attention upon the response rather than the stimulus, but individuals do not all react in the same way so that a stimulus that is stressful to one is ignored, disregarded or not reacted to by another. Other investigators prefer to regard a particular stimulus (which they then call a stressor) as uniformly stressful, even though some individuals may not react in the anticipated manner, and some hardly at all. Surgery powerfully activates the hypothalamo—pituitary—adrenocortical system, and thus raises the output of the adrenal steroid cortisol, but the prospect of surgery can be just as effective, as can admission to hospital, the prospect of a college or university examination, or the expectation of exhausting physical exercise. On the one hand the physiological response to stress, as after injury, is of greatest concern, while on the other psychological factors, as in the assessment of the degree of personal threat, is paramount. Because of difficulties in classifying the stimuli, greater regard has been paid to the physiological response, but with repeated exposure to stress adaptation may occur, so complicating definition of a stress.


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  1. Antelman, S.M. and Chiodo, L.A. (1984). Stress: its effects on interactions among biogenic amines and role in the induction and treatment of disease. In: Handbook of Psychopharmacology. Vol. 18. Drugs, Neurotransmitters, and Behavior. Eds. L.L. Iversen, S.D Iversen and S.H. Snyder, pp. 279–341. New York: Plenum Press.CrossRefGoogle Scholar
  2. Blalock, J.E. (1984). The immune system as a sensory organ. Journal of Immunology, 132, 1067–70.Google Scholar
  3. Cohen, F. (1983). Stress, emotion and illness. In: Emotions in Health and Illness. Eds. L. Temoshok, C. Van Dyke and L.S. Zegans, pp. 31–5. New York: Grune & Stratton.Google Scholar
  4. Dimsdale, J.E. and Moss, J. (1980). Plasma catecholamines in stress and exercise. Journal of the American Medical Association, 243, 340–2.CrossRefGoogle Scholar
  5. Dunn, A.J. and Kramarcy, N.R. (1984). Neurochemical responses in stress:. relationships between the hypothalamic-pituitary-adrenal and catecholamine systems. In: Handbook of Psychopharmacology. Vol. 18. Drugs, Neurotransmitters, and Behavior. Eds. L.L. Iversen, S.D. Iversen and S.H. Snyder, pp. 455–515. New York: Plenum Press.CrossRefGoogle Scholar
  6. Frankenhaeuser, M. (1979). Psychoneuroendocrine approaches to the study of emotion as related to stress and coping. Nebraska Symposium on Motivation, 26, 123–61.Google Scholar
  7. Frankenhaeuser, M. (1982). Challenge-control interaction as reflected in sympathetic-adrenal and pituitary-adrenal activity: comparison between the sexes. Scandinavian Journal of Psychology, Suppl. 1, 158–64.CrossRefGoogle Scholar
  8. Gibbs, D.M. (1986). Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review. Psychoneuroendocrinology, 11, 131–9.CrossRefGoogle Scholar
  9. Irwin, J. and Anisman, H. (1984). Stress and pathology: immunological and central nervous system interactions. In: Psychosocial Stress and Cancer. Ed. C.L. Cooper, pp. 93–147. Chichester: John Wiley.Google Scholar
  10. Komisaruk, B.R. and Whipple, B. (1986). Vaginal stimulation-produced analgesia in rats and women. Annals of the New York Academy of Sciences, 467, 30–9.CrossRefGoogle Scholar
  11. Kosten, T.R., Jacobs, S., Mason, J., Wahby, V. and Atkins, S. (1984). Psychological correlates of growth hormone response to stress. Psychosomatic Medicine, 46, 49–58.CrossRefGoogle Scholar
  12. Lewis, J.W., Terman, G.W., Nelson, L.R. and Liebeskind, J.C. (1984). Opioid and non-opioid stress analgesia. In: Stress-induced Analgesia. Eds. M.D. Tricklebank and G. Curzon, pp. 103–33. Chichester: John Wiley.Google Scholar
  13. Mason, J.W. (1968). ‘Over-all’ hormonal balance as a key to endocrine organization. Psychological Medicine, 30, 791–808.CrossRefGoogle Scholar
  14. Munck, A., Guyre, P.M. and Holbrook, N.J. (1984). Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Reviews, 5, 25–44.CrossRefGoogle Scholar
  15. Rose, R.M. (1984). Overview of endocrinology of stress. In: Neuroendocrinology and Psychiatric Disorder. Eds. G.M. Brown, S.H. Koslow and S. Reichlin, pp. 95–122. New York: Raven Press.Google Scholar
  16. Schindler, B.A. (1985). Stress, affective disorders and immune function. Medical Clinics of North America, 69, 585–97.Google Scholar
  17. Selye, H. (1957). The Stress of Life. London: Longmans, Green.Google Scholar
  18. Wolff, C.T., Friedman, S.B., Hofer, M.A. and Mason, J.W. (1964). Relationship between psychological defenses and mean urinary 17-hydroxycorticosteroid excretion rates. 1. A predictive study of parents of fatally ill children. Psychosomatic Medicine, 26, 576–91.CrossRefGoogle Scholar
  19. Zacharko, R.M. and Anisman, H. (1984). Motor, motivational and anti-nociceptive consequences of stress: contribution of neurochemical changes. In: Stress-induced Analgesia. Eds. M.D. Tricklebank and G. Curzon, pp. 33–65. Chichester: John Wiley.Google Scholar

Copyright information

© Bernard T. Donovan 1988

Authors and Affiliations

  • Bernard T. Donovan
    • 1
  1. 1.Department of PhysiologyInstitute of PsychiatryLondonUK

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