Abstract
Metabolism of exogenous chemicals by the cytochrome P-450 mono-oxygenase system (P-450 system) of various tissues and cells is necessarily dependent upon the contents and specificities of the individual isozymes of cytochrome P-450 present. Therefore, we should be able to relate differences in tissue or cellular metabolism of xenobiotics to constitutive isozyme profiles and to differential changes in profiles due to the inductive and/or repressive effects of chemical modulators of P-450 synthesis. The complexity of P-450 isozyme profiles requires that sensitive methods for detection and quantitation be employed and that these methods be applicable to different tissues and cell types under both native and altered conditions. Our past studies of rabbit liver and lung have pointed out a number of marked differences and similarities between the P-450 systems of these two tissues (Philpot & Wolf, 1981). With the development of highly sensitive immunochemical methods, we have now been able to examine P-450 systems in greater detail and have extended our observations to other tissues and species.
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© 1984 Macmillan Publishers Limited
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Domin, B.A. et al. (1984). Tissue and cellular differences in the expression of cytochrome P-450 isozymes. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_32
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DOI: https://doi.org/10.1007/978-1-349-17615-1_32
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-0-333-37136-7
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