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Effect of prostanoids on the coronary circulation

  • Å. Wennmalm
  • A. Edlund
  • L. Kaijser
  • C. Patrono

Abstract

After the discovery of prostacyclin (PGI2) (Moncada et al., 1976) the pronounced biological actions of this compound led to a number of different hypotheses concerning its role in various physiological and pathophysiological states. Due to its continuous formation in the vascular endothelium throughout the systemic and pulmonary circulatory systems the platelet anti-aggregatory effect of PGI2 was considered to balance the pro-aggregatory effect of thromboxane A2 (TxA2) (Gryglewski et al., 1976). The vasodilator action of PGI2 was also considered to be of significance in the local regulation of blood flow in various tissues, especially in the coronary circulation. The expectations on an important role of PGI2 in coronary physiology were based not only on the coronary relaxant effect of the compound observed in studies on isolated coronary vessels from various species, including man, but also on studies on inhibition of prostaglandin (PG) formation in various animal in vivo models.

Keywords

Acute Myocardial Infarction Coronary Sinus Ischaemic Heart Disease Coronary Blood Flow Coronary Circulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. AFONSO, S., BANDOW, G.T. & ROWE, G.G (1974). Indomethacin and the prostaglandin hypothesis of coronary blood flow regulation. J. Physiol., 241, 299–308.PubMedPubMedCentralCrossRefGoogle Scholar
  2. ALEXANDER, R.W., KENT, K.M., PISANO, J.J., KEISER, H.R. & COOPER, T. (1975). Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart. J. din. Invest., 55, 1174–1181.Google Scholar
  3. ALTURA, B. & CHAND, N. (1981). Bradykinin-induced relaxation of renal and pulmonary arteries is dependent upon intact endothelial cells. Br. J. Pharmac., 74, 10–11.CrossRefGoogle Scholar
  4. ARAKI, H. & LEFER, A.M. (1980). Role of prostacyclin in the preservation of ischemic myocardial tissue in the perfused cat heart. Circ. Res., 47, 757–763.PubMedCrossRefGoogle Scholar
  5. DE DECKERE, E.A.M., NUGTEREN, D.H. & TEN HOOR, F. (1977). Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart. Nature, 268, 160–163.PubMedCrossRefGoogle Scholar
  6. DE MEY, J.G. & VANHOUTTE, P.M. (1981). Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J. Physiol., 316, 347–355.PubMedPubMedCentralCrossRefGoogle Scholar
  7. EDLUND, A., BOMFIM, W., KAIJSER, L., OLIN, C., PATRONO, C., PINCA, E. & WENNMALM, Å. (1982). Pulmonary formation of prostacyclin in man. Prostaglandins, 22, 323–331.CrossRefGoogle Scholar
  8. FRIEDMAN, P.L., BROWN, E.J., GUNTHER, S., ALEXANDER, R.W., BARRY, H.W., MUDGE, G.H. & GROSSMAN, W. (1981). Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease. New Engl. J. Med., 305, 1171–1175.PubMedCrossRefGoogle Scholar
  9. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373–376.PubMedCrossRefGoogle Scholar
  10. GILES, R.W. & WILCKEN, D.E.L. (1977). Reactive hyperemia in the dog heart: inter-relations between adenosine, ATP, and aminophylline and the effect of indomethacin. Cardiovasc. Res., 11, 113–121.PubMedCrossRefGoogle Scholar
  11. GORDON, J.L. & MARTIN, W. (1982). Responses of porcine aortic endothelial cells to vasodilator agents. Proc. Physiol. Soc., 45P–46P.Google Scholar
  12. GRYGLEWSKI, R.J., BUNTING, S., MONCADA, S., FLOWER, R.J. & VANE, J. (1976). Arterial walls are protected against deposition of platelet thrombi by a substance (Prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins, 12, 685–713.PubMedCrossRefGoogle Scholar
  13. HINTZE, T.H. & KALEY, G. (1977). Prostaglandins and the control of blood flow in the canine myocardium. Circ. Res., 40, 313–320.PubMedCrossRefGoogle Scholar
  14. ISAKSON, P.C., RAZ, A., DENNY, S.E., PURE, E. & NEEDLEMAN, P. (1977). A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart. Proc. natn. Acad. Sci. U.S.A., 74, 101–105.CrossRefGoogle Scholar
  15. JUGDUTT, B.I., HUTCHINS, G.M., BULKLEY, B.H. & BECKER, L.C. (1981). Dissimilar effects of prostacyclin, prostaglandin E1, and prostaglandin E2 on myocardial infarct size after coronary occlusion in conscious dogs. Circ. Res., 49, 685–700.PubMedCrossRefGoogle Scholar
  16. KRAEMER, R.J., PHERNETTON, T.M. & FOLTS, J.D. (1976). Prostaglandin-like substances in coronary venous blood following myocardial ischemia. J. Pharmac. exp. Ther., 199, 611–619.Google Scholar
  17. MONCADA, S., GRYGLEWSKI, R., BUNTING, S. & VANE, J.R. (1976). An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature, 263, 663–665.PubMedCrossRefGoogle Scholar
  18. NEEDLEMAN, P. & KALEY, G. (1978). Cardiac and coronary prostaglandin synthesis and function. New Engl. J. Med., 298, 1122–1128.PubMedCrossRefGoogle Scholar
  19. RAZ, A., ISAKSON, P.C., MINKES, M.S. & NEEDLEMAN, P. (1977). Characterization of a novel metabolic pathway of arachidonate in coronary arteries which generates a potent endogenous coronary vasodilator. J. biol. Chem., 252, 1123–1126.PubMedGoogle Scholar
  20. SCHRÖR, K., MONCADA, S., UBATUBA, F.B. & VANE, J.R. (1978). Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart, formation of RCS and prostacyclin. Eur. J. Pharmac., 47, 103–114.CrossRefGoogle Scholar
  21. VANE, J.R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol., 231, 232–235.PubMedCrossRefGoogle Scholar

Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • Å. Wennmalm
    • 1
  • A. Edlund
    • 1
  • L. Kaijser
    • 2
  • C. Patrono
    • 3
  1. 1.Department of Clinical PhysiologyKarolinska Institute, Huddinge University HospitalStockholmSweden
  2. 2.Huddinge University Hospital, and Karolinska HospitalStockholmSweden
  3. 3.Department of PharmacologyCatholic UniversityRomeItaly

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