Regulation of 5-hydroxytryptamine (5HT) uptake: endocoid modulators and the action of imipramine

  • E. Costa
  • M. L. Barbaccia


The monoamine hypothesis of affective disorders (Schildkraut, 1965; Van Praag, 1978) was initiated and fostered by extrapolation from animal experimentation (Brodie et al., 1956; Brodie & Shore, 1957; Costa et al., 1960). It is surprising how the doctrinality of this hypothesis has promoted the popularity of this theory despite the fact that no one has ever succeeded in providing convincing evidence that an altered amine metabolism is present in manic depressive illness. Though many antidepressants, both tricyclic and monoamine oxidase inhibitors potentiate the action of biogenic amines in the CNS by blocking one of the two major pathways for monoamine inactivation (Carlsson et al., 1959; Quitkin et al., 1979) there are a number of antidepressants (Leonard, 1982; Sulser, 1982), which do not potentiate the central effects of biogenic amines. Moreover, there are potent inhibitors of catecholamine uptake (Post et al., 1979) which are poor anti-depressants.


Recognition Site Monoamine Uptake Specific Recognition Site Gaba Receptor Agonist Serotonergic Axon 
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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • E. Costa
    • 1
  • M. L. Barbaccia
    • 1
  1. 1.Laboratory of Preclinical PharmacologyNIMH, Saint Elizabeths HospitalWashington, D.CUSA

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